Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis
Min Wei,
Qiaoji Jiang,
Shuang Bian
и другие.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 29, 2025
With
the
progress
of
atherosclerosis
(AS),
arterial
lumen
stenosis
and
compact
plaque
structure,
thickening
intima
narrow
gaps
between
endothelial
cells
significantly
limit
penetration
efficiency
nanoprobe
to
plaque,
weakening
imaging
sensitivity
therapy
efficiency.
Thus,
in
this
study,
a
H2O2-NIR
dual-mode
nanomotor,
Gd-doped
mesoporous
carbon
nanoparticles/Pt
with
rapamycin
(RAPA)
loading
AntiCD36
modification
(Gd-MCNs/Pt-RAPA-AC)
was
constructed.
The
asymmetric
deposition
Pt
on
Gd-MCNs
catalyzed
H2O2
at
inflammatory
site
produce
O2,
which
could
promote
self-motion
nanomotor
ease
inflammation
microenvironment
AS
plaque.
Near-infrared
(NIR)
laser
irradiation
promoted
photothermal
conversion
generate
thermal
propulsion
ablation
macrophages.
Meanwhile,
bind
macrophages
further
promotes
targeting
effect.
released
RAPA
inhibit
side
effects
caused
by
effects,
macrophage
autophagy
hinder
development
AS.
nanomotors
combining
synergistic
treatment,
anti-inflammatory
pro-autophagy
provided
improved
theranositc
effect
Язык: Английский
Machine learning‐assisted point‐of‐care diagnostics for cardiovascular healthcare
Bioengineering & Translational Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Abstract
Cardiovascular
diseases
(CVDs)
continue
to
drive
global
mortality
rates,
underscoring
an
urgent
need
for
advancements
in
healthcare
solutions.
The
development
of
point‐of‐care
(POC)
devices
that
provide
rapid
diagnostic
services
near
patients
has
garnered
substantial
attention,
especially
as
traditional
systems
face
challenges
such
delayed
diagnoses,
inadequate
care,
and
rising
medical
costs.
advancement
machine
learning
techniques
sparked
considerable
interest
research
engineering,
offering
ways
enhance
accuracy
relevance.
Improved
data
interoperability
seamless
connectivity
could
enable
real‐time,
continuous
monitoring
cardiovascular
health.
Recent
breakthroughs
computing
power
algorithmic
design,
particularly
deep
frameworks
emulate
neural
processes,
have
revolutionized
POC
CVDs,
enabling
more
frequent
detection
abnormalities
automated,
expert‐level
diagnosis.
However,
privacy
concerns
biases
dataset
representation
hinder
clinical
integration.
Despite
these
barriers,
the
translational
potential
learning‐assisted
presents
significant
opportunities
CVDs
healthcare.
Язык: Английский
Tissue Clearing and Its Application in Nanoparticle Development
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Abstract
Nanoparticles
are
widely
used
in
biomedical
applications
due
to
their
small
size,
large
surface
area,
and
unique
physicochemical
properties.
These
characteristics
make
them
ideal
for
drug
delivery,
diagnostic
imaging,
therapeutic
interventions.
Their
ability
interact
with
biological
systems
at
the
cellular
molecular
levels
enables
targeted
treatments.
Understanding
biodistribution
of
nanoparticles
level
within
whole
organisms
is
crucial
assessing
safety
effectiveness;
however,
proper
technologies
have
been
lacking
achieve
this.
For
example,
traditional
imaging
techniques
like
magnetic
resonance
(MRI)
computed
tomography
(CT)
often
lack
resolution
needed,
while
tissue‐section‐based
methods
miss
whole‐body
systemic
view.
Recent
tissue
clearing
emerged
as
a
promising
solution
3D
visualization
entire
organs,
they
enable
cellular‐level
without
need
sectioning.
This
review
explores
advancements
diverse
application
studying
nanoparticle
biodistribution,
providing
insights
development
nanoparticle‐based
therapies.
Язык: Английский
An Assessment of the Efficacy of Erbium Glass Laser Therapy in Acne Scar Treatment Using Image Analysis and Processing Methods
Applied Sciences,
Год журнала:
2025,
Номер
15(7), С. 3954 - 3954
Опубликована: Апрель 3, 2025
Background:
Acne
scars
significantly
impact
skin
texture
and
esthetics,
necessitating
effective
treatment
modalities.
This
study
evaluates
the
efficacy
of
erbium
glass
laser
therapy
in
improving
atrophic
acne
using
advanced
image
analysis
techniques.
Materials
methods:
Twenty
patients
with
mild
to
moderate
underwent
two
sessions
1550
nm
treatment.
The
clinical
photographs
were
analyzed
a
Gray-Level
Co-occurrence
Matrix
(GLCM)
assess
changes
contrast
homogeneity
across
grayscale
RGB
channels.
revealed
statistically
significant
improvements
post-therapy,
including
reduced
increased
homogeneity,
indicating
smoother
more
uniform
texture.
blue
green
channels
demonstrated
greatest
sensitivity
surface-level
textural
changes,
while
red
channel
exhibited
smallest
differences,
reflecting
its
deeper
penetration
surface
alterations.
Conclusions:
These
findings
underscore
value
quantitative
imaging
techniques
dermatology
for
objectively
evaluating
therapeutic
outcomes
optimizing
strategies.
Erbium
emerges
as
non-invasive
solution
scar
management.
Язык: Английский
Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Abstract
In
recent
years,
nanomaterials
have
demonstrated
broad
prospects
in
the
diagnosis
and
treatment
of
retinal
diseases
due
to
their
unique
physicochemical
properties,
such
as
small‐size
effects,
high
biocompatibility,
functional
surfaces.
Retinal
are
often
accompanied
by
complex
pathological
microenvironments,
where
conventional
diagnostic
therapeutic
approaches
face
challenges
low
drug
delivery
efficiency,
risks
associated
with
invasive
procedures,
difficulties
real‐time
monitoring.
Nanomaterials
hold
promise
addressing
these
limitations
traditional
therapies,
thereby
improving
precision
efficacy.
The
applications
diagnostics
summarized,
they
enable
high‐resolution
imaging
carrying
fluorescent
probes
or
contrast
agents
act
biosensors
sensitively
detect
disease‐related
biomarkers,
facilitating
early
dynamic
therapeutics,
functionalized
nanocarriers
can
precisely
deliver
drugs,
genes,
antioxidant
molecules
target
cells,
significantly
enhancing
outcomes
while
reducing
systemic
toxicity.
Additionally,
nanofiber
materials
possess
properties
that
make
them
particularly
suitable
for
regeneration
tissue
engineering.
By
loading
neurotrophic
factors
into
scaffolds,
regenerative
effects
be
amplified,
promoting
repair
neurons.
Despite
immense
potential,
clinical
translation
still
requires
long‐term
biosafety,
scalable
manufacturing
processes,
optimization
targeting
efficiency.
Язык: Английский
Advances in posterity of visualization in paradigm of nano‐level ultra‐structures for nano–bio interaction studies
View,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
The
progression
in
contemporary
scientific
field
is
facilitated
by
a
multitude
of
sophisticated
and
cutting‐edge
methodologies
that
are
employed
for
various
research
purposes.
Among
these
methodologies,
microscopy
stands
out
as
fundamental
essential
technique
utilized
investigations.
Moreover,
due
to
the
continuous
evolution
enhancement
microscopic
nanotechnology
has
reached
highly
developed
stage
within
modern
realm,
particularly
renowned
its
wide‐ranging
applications
fields
biomedicine
environmental
science.
When
it
comes
conducting
comprehensive
in‐depth
experimental
analyses
explore
nanotechnological
aspects
relevant
biological
applications,
concept
nano–biological
interaction
emerges
focal
point
any
initiative.
Nonetheless,
this
particular
study
necessitates
meticulous
approach
toward
imaging
visualization
at
diverse
magnification
levels
ensure
accurate
observations
interpretations.
It
widely
acknowledged
emerged
invaluable
instrument
regard.
This
review
aims
provide
discussion
on
progress
made
techniques
specifically
tailored
visualizing
interactions
between
nanostructures
entities,
thereby
facilitating
exploration
practical
realm
sciences.
Язык: Английский