Translational Psychiatry,
Год журнала:
2020,
Номер
10(1)
Опубликована: Июнь 17, 2020
Abstract
Omega-3
fatty
acids
(FA),
as
a
nutrient,
has
been
proven
effective
in
major
depressive
disorder
(MDD),
however,
the
results
of
monotherapy
perinatal
depression
(PND)
remain
unclear.
To
examine
efficacy
and
safety
omega-3
(FA)
for
compared
with
placebo.
PubMed,
Embase,
PsycINFO,
MEDLINE,
Cochrane
Library,
CINAHL
were
searched
from
inception
up
to
November
2019.
The
reference
lists
relevant
review
articles
included
studies
also
reviewed.
Randomized
placebo-controlled
trials
examining
FA
women
symptoms
included.
Pooled
standard
mean
differences
(SMD)
calculated
random-effects
models
adopted
all
analyses.
Subgroups
analyses
meta-regression
performed
quantify
characteristics
subjects
influencing
response.
In
addition,
was
conducted
identify
source
heterogeneity.
study
protocol
registered
at
PROSPERO,
CRD42020159542.
Eight
eligible
randomized
involving
638
participants.
There
significant
effect
on
depression.
higher
ratio
EPA/DHA
(≥1.5)
had
both
mild-to-moderate
pregnant
postpartum
low
incidence
side
effects.
Among
reporting
adverse
effects,
there
no
difference
gastrointestinal
neurologic
events
between
placebo
groups.
evidence
publication
bias.
Our
findings
suggested
that
significantly
improved
regardless
or
well-tolerated.
Furthermore,
response
linked
EPA
proportion
formula
mild-
to-moderate
Journal of Lipid Research,
Год журнала:
2024,
Номер
65(6), С. 100548 - 100548
Опубликована: Апрель 21, 2024
DHA
is
abundant
in
brain
where
it
regulates
cell
survival,
neurogenesis
and
neuroinflammation.
can
be
obtained
from
the
diet
or
synthesized
alpha-linolenic
acid
(ALA;
18:3n-3)
via
a
series
of
desaturation
elongation
reactions
occurring
liver.
Tracer
studies
suggest
that
dietary
downregulate
its
own
synthesis,
but
mechanism
remains
undetermined
primary
objective
this
paper.
First,
we
show
by
tracing
13C
content
(δ13C)
compound-specific
isotope
analysis
(CSIA),
following
low
DHA,
receives
ALA.
We
then
increases
mouse
liver
serum
EPA,
which
dependant
on
Furthermore,
CSIA
demonstrate
source
increased
EPA
slowed
metabolism,
not
retroconversion
as
previously
assumed.
feeding
alone
with
ALA
lowered
very
long-chain
(ELOVL2,
elongation)
enzyme
activity
despite
no
change
protein
content.
To
further
evaluate
role
ELOVL2,
liver-specific
Elovl2
knockout
was
generated
showing
presence
absence
functional
ELOVL2
yields
similar
results.
An
competition
assay
for
suggests
both
uncompetitive
non-competitive
inhibition
depending
levels.
translate
our
findings,
supplementation
men
women
levels
manner
dependent
SNP
(rs953413)
gene.
In
conclusion,
identify
novel
feedback
pathway
downregulates
synthesis
inhibiting
elongation.
Translational Psychiatry,
Год журнала:
2020,
Номер
10(1)
Опубликована: Июнь 17, 2020
Abstract
Omega-3
fatty
acids
(FA),
as
a
nutrient,
has
been
proven
effective
in
major
depressive
disorder
(MDD),
however,
the
results
of
monotherapy
perinatal
depression
(PND)
remain
unclear.
To
examine
efficacy
and
safety
omega-3
(FA)
for
compared
with
placebo.
PubMed,
Embase,
PsycINFO,
MEDLINE,
Cochrane
Library,
CINAHL
were
searched
from
inception
up
to
November
2019.
The
reference
lists
relevant
review
articles
included
studies
also
reviewed.
Randomized
placebo-controlled
trials
examining
FA
women
symptoms
included.
Pooled
standard
mean
differences
(SMD)
calculated
random-effects
models
adopted
all
analyses.
Subgroups
analyses
meta-regression
performed
quantify
characteristics
subjects
influencing
response.
In
addition,
was
conducted
identify
source
heterogeneity.
study
protocol
registered
at
PROSPERO,
CRD42020159542.
Eight
eligible
randomized
involving
638
participants.
There
significant
effect
on
depression.
higher
ratio
EPA/DHA
(≥1.5)
had
both
mild-to-moderate
pregnant
postpartum
low
incidence
side
effects.
Among
reporting
adverse
effects,
there
no
difference
gastrointestinal
neurologic
events
between
placebo
groups.
evidence
publication
bias.
Our
findings
suggested
that
significantly
improved
regardless
or
well-tolerated.
Furthermore,
response
linked
EPA
proportion
formula
mild-
to-moderate
