Biogerontology, Год журнала: 2025, Номер 26(2)
Опубликована: Фев. 18, 2025
Язык: Английский
World Psychiatry, Год журнала: 2023, Номер 22(3), С. 394 - 412
Опубликована: Сен. 15, 2023
Treatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD demonstrated predictive utility in terms clinical decision-making outcomes does not currently exist. Instead, a plethora definitions have been proposed, which vary significantly their conceptual framework. The absence hampers precise estimates the prevalence TRD, also belies efforts to identify risk factors, prevention opportunities, effective interventions. In addition, it results heterogeneity practice decision-making, adversely affecting quality care. US Food Drug Administration (FDA) European Medicines Agency (EMA) adopted most used (i.e., inadequate response minimum two antidepressants despite adequacy treatment trial adherence treatment). It estimated that at least 30% persons meet this definition. significant percentage are actually pseudo-resistant (e.g., due inadequacy trials or non-adherence Although sociodemographic, clinical, contextual factors known negatively moderate depression, very few regarded as non-response across modalities treatment. Intravenous ketamine intranasal esketamine (co-administered an antidepressant) established efficacious management TRD. Some second-generation antipsychotics aripiprazole, brexpiprazole, cariprazine, quetiapine XR) proven adjunctive treatments partial responders, but only olanzapine-fluoxetine combination has studied FDA-defined Repetitive transcranial magnetic stimulation (TMS) FDA-approved for individuals accelerated theta-burst TMS recently showing efficacy. Electroconvulsive therapy acute maintenance intervention preliminary evidence suggesting non-inferiority intravenous ketamine. Evidence extending antidepressant trial, medication switching combining mixed. Manual-based psychotherapies on own offer symptomatic relief when added conventional antidepressants. Digital therapeutics under study represent potential future vista population.
Язык: Английский
Процитировано
256
European Heart Journal, Год журнала: 2024, Номер unknown
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
115
International Journal of Science and Research Archive, Год журнала: 2024, Номер 11(1), С. 383 - 395
Опубликована: Янв. 20, 2024
This comprehensive review examines the intricate relationship between demographic shifts, specifically aging of populations, and systemic challenges faced by healthcare systems globally. As societies experience a significant increase in life expectancy decline birth rates, proportion elderly individuals within population is on rise. transformation poses multifaceted to systems, necessitating thorough exploration its implications. The first delves into presenting nuanced analysis factors contributing populations. Exploring advancements healthcare, lifestyle changes, socio-economic factors, paper establishes foundation for understanding dynamics driving this global phenomenon. Subsequently, focus shifts towards sector, elucidating manifold arising from demographic. With surge chronic diseases age-related conditions, are confronted with increased demand specialized long-term care. has far-reaching implications resource allocation, workforce planning, overall sustainability infrastructures. also highlights importance addressing psychological social dimensions aging, emphasizing need holistic approaches that go beyond traditional medical paradigms. Societal attitudes, stigma, provision adequate support become crucial considerations achieving patient-centered care elderly. In conclusion, underscores urgency adapt particularly posed It advocates proactive approach, calling policy interventions, innovative models, re-evaluation societal perspectives aging. By navigating complexities inherent transitions, can strive inclusivity, sustainability, improved quality growing population.
Язык: Английский
Процитировано
23
Advances in healthcare information systems and administration book series, Год журнала: 2024, Номер unknown, С. 20 - 46
Опубликована: Фев. 14, 2024
This chapter examines the concept of mental health literacy (MHL) and its pivotal role in promoting well-being global agendas. MHL, rooted recognition, understanding, management disorders, has emerged as a critical component fostering individual community resilience. The delves into transformative potential digital tools enhancing MHL through innovative education approaches, focusing on platforms, mobile apps, virtual reality, artificial intelligence, gamified learning to disseminate personalized information efficiently, transcending barriers time stigma. comprehensively explores state-of-the-art integration not only healthcare professionals training curricula but also populations. Through some examples real case study, effectiveness different interventions is highlighted, culminating practical recommendations for seamlessly incorporating initiatives.
Язык: Английский
Процитировано
19
Sustainability, Год журнала: 2023, Номер 15(23), С. 16503 - 16503
Опубликована: Дек. 2, 2023
Background: Global population aging poses challenges for healthcare. Digital health technologies may benefit older adults through enhanced access, monitoring, and self-care. This systematic review evaluates the intersection of digital interventions healthy aging, focusing on adoption, efficacy, user experience. Methods: PubMed, Embase, Cochrane Library were systematically searched studies aged 50+ years. Randomized controlled trials, observational studies, surveys, qualitative included. Outcomes adoption rates, feedback. Study quality was assessed using standardized tools. Results: 15 Adoption increased during COVID-19, but divisions persist. Barriers like technology distrust require addressing. Web-based programs telerehabilitation demonstrated benefits behaviors balance. Users had positive attitudes emphasized patient-centric, ethical design. Most efficacy data preliminary; more rigorous trials are needed. Discussion: show promise supporting thoughtful implementation strategies tailored to needs capacities essential realizing equitably. More research real-world integration ethics warranted. Conclusions: has significant potential promoting However, evidence-based, patient-centered solutions imperative maximize experience diverse adult populations.
Язык: Английский
Процитировано
25
BMC Psychiatry, Год журнала: 2024, Номер 24(1)
Опубликована: Янв. 22, 2024
Abstract Background In India, the prevalence of depression among older adults dealing with multiple health conditions varies between rural and urban areas due to disparities in healthcare access cultural factors. The distinct patterns observed underscore necessity for tailored research interventions address mental inequalities multimorbid patients diverse geographic contexts. Methods This study used data from Longitudinal Ageing Study India (LASI) wave 1 (2017–18). A total 7,608 aged ≥ 60 years who were diagnosed two or more chronic (such as hypertension, diabetes, cancer, lung disease, heart diseases, stroke, bone/joint any neurological psychiatric high cholesterol) included this study. Descriptive statistics, bivariate analysis, logistic regression estimates, Fairlie decomposition method accomplish study’s objectives. Results multimorbidity was 9.48% higher (38.33%) than (28.85%).. Older belonging scheduled caste group 40% likely experience depression. Moreover, those form disability activities daily living (ADL) 93% without disability, whereas perceived good general 65% less suffer poor self-perceived health. Additionally, analysis revealed that education (35.99%), status (10.30%), IADL (19.30%), discrimination (24.25%) primary factors contributing differences areas. Conclusions We found significant rural–urban Indians multimorbidity. findings need targeted unique challenges faced by areas, including lack social capital, discrimination, limited resources enable services. Policymakers professionals must collaboratively design implement effective strategies improve overall well-being adults, particularly comorbidities.
Язык: Английский
Процитировано
11
Frontiers in Public Health, Год журнала: 2025, Номер 12
Опубликована: Янв. 24, 2025
Background The differential impacts of various social activities on dementia prevention and the mediating role depression in this relationship remain unclear. Objectives This study aimed to identify effects different cognitive function, examine depression, provide evidence for targeted interventions prevent decline. Methods Using data from CHARLS, we employed RCS analysis Structural Equation Modeling relationships between activities, function older adults. Results Social activity participation is non-linearly inversely related both impairment risk. Cognitive were significantly mediated by depression. Cognitively stimulating physically had greatest positive mental health. Conclusion Our findings highlight complex interplay engagement, health aging. They support developing promoting physical maintain reduce risk adults, potentially alleviating burden aging populations.
Язык: Английский
Процитировано
1
General Hospital Psychiatry, Год журнала: 2025, Номер 93, С. 127 - 128
Опубликована: Фев. 8, 2025
Язык: Английский
Процитировано
1
Journal of Personalized Medicine, Год журнала: 2022, Номер 12(12), С. 2070 - 2070
Опубликована: Дек. 15, 2022
The present study aims to provide a critical overview of the literature on relationships between post-acute COVID-19 infection and cognitive impairment, highlighting limitations confounding factors. A systematic search articles published from 1 January 2020 July 2022 was performed in PubMed/Medline. We followed Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Only studies using validated instruments assessment impairment were included. Out 5515 screened records, 72 met inclusion criteria. available evidence revealed presence executive functions, speed processing, attention memory subjects recovered COVID-19. However, several reviewed should be highlighted: most small samples, not stratified by severity disease age, used as cross-sectional or short-term longitudinal design provided limited different domains. Few investigated neurobiological correlates deficits individuals Further with an adequate methodological are needed in-depth characterization
Язык: Английский
Процитировано
33
Schizophrenia Bulletin, Год журнала: 2023, Номер 49(4), С. 851 - 866
Опубликована: Апрель 6, 2023
Abstract Background and Aims Social determinants of health (SDoHs) impact the development course schizophrenia-spectrum psychotic disorders (SSPDs). Yet, we found no published scholarly reviews psychometric properties pragmatic utility SDoH assessments among people with SSPDs. We aim to review those aspects assessments. Study Design PsychInfo, PubMed, Google Scholar databases were examined obtain data on reliability, validity, administration process, strengths, limitations measures for SDoHs identified in a paired scoping review. Results assessed using different approaches including self-reports, interviews, rating scales, public databases. Of major SDoHs, early-life adversities, social disconnection, racism, fragmentation, food insecurity had satisfactory properties. Internal consistency reliabilities—evaluated general population 13 insecurity—ranged from poor excellent (0.68–0.96). The number items varied 1 more than 100 time ranged less 5 minutes over an hour. Measures urbanicity, low socioeconomic status, immigration homelessness/housing instability, incarceration based records or targeted sampling. Conclusions Although reported show promise, there is need develop test brief but validated screening suitable clinical application. Novel assessment tools, objective at individual community levels utilizing new technology, sophisticated evaluations sensitivity change effective interventions are recommended, suggestions training curricula offered.
Язык: Английский
Процитировано
16