A Systematic Review on the Prevalence of Comorbid Substance Use Disorder in Obsessive–Compulsive Disorder Among the General Population

Psychoactives, Год журнала: 2025, Номер 4(1), С. 2 - 2

Опубликована: Янв. 17, 2025

Background: To estimate the prevalence of co-occurring obsessive–compulsive disorder (OCD) with substance use (SUD) in general population. Methods: A comprehensive literature search was conducted on comorbid OCD and SUD population using MEDLINE, PsycINFO, EMBASE CINAHL. Using keywords, relevant studies published between 1993 2021 were identified. These analysed Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) guidelines Meta-analysis Observational Studies Epidemiology. Results: Fourteen met inclusion criteria had a total combined sample size 47,850 participants. The lifetime any identified patients ranged 4.3% 62.4%. Among AUD, 14.1% 35.9%; cannabis OCD, 11.5% 24.4%; tobacco 15% 23.1%. Alcohol commonest psychoactive used most reviewed highest males. Conclusions: In conclusion, this review highlights variable SUDs individuals emphasizing that association differs based type substance. Overall, rate underscores need further research relationship these conditions development effective treatment strategies address both disorders concurrently.

Язык: Английский

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The resting-state brain activity signatures for addictive disorders

Med, Год журнала: 2024, Номер 5(3), С. 201 - 223.e6

Опубликована: Фев. 14, 2024

Язык: Английский

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Behavioral and neuronal extracellular vesicle biomarkers associated with nicotine's enhancement of the reinforcing strength of cocaine in female and male monkeys

Addiction Neuroscience, Год журнала: 2024, Номер 11, С. 100151 - 100151

Опубликована: Фев. 15, 2024

While the majority of people with cocaine use disorders (CUD) also co-use tobacco/nicotine, most preclinical research does not include nicotine. The present study examined nicotine and under several conditions intravenous drug self-administration in monkeys, as well potential peripheral biomarkers associated co-use. In Experiment 1, male rhesus monkeys (N=3) self-administered (0.001-0.1 mg/kg/injection) alone (0.01-0.03 a progressive-ratio schedule reinforcement. When was added to cocaine, there significant leftward/upward shift number injections received. 2, socially housed female cynomolgus (N=14) concurrent drug-vs-food choice Adding solution shifted dose-response curves left, more robust shifts noted animals. There no evidence social rank differences. To assess reinforcing strength, delays were presentation drug; required significantly longer decrease choice, compared alone. Blood samples obtained post-session used analyze concentrations neuronally derived small extracellular vesicles (NDE); differences NDE profile observed for kappa-opioid receptors when co-used each controls. These results suggest that interactions involving are simply changing potency, but rather resulting changes strength should be utilized better understand neuropharmacology CUD evaluation treatments.

Язык: Английский

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An International, Multidisciplinary Consensus Set of Patient-Centered Outcome Measures for Substance-Related and Addictive Disorders

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(7), С. 2154 - 2154

Опубликована: Апрель 8, 2024

In 1990, the United States' Institute of Medicine promoted principles outcomes monitoring in alcohol and other drugs treatment field to improve evidence synthesis quality research. While various national outcome measures have been developed employed, no global consensus on standard measurement has agreed for addiction. It is thus timely build an international consensus. Convened by International Consortium Health Outcomes Measurement (ICHOM), international, multi-disciplinary working group reviewed existing literature reached a globally applicable minimum set people who seek

Язык: Английский

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Enhancing Substance Use Disorder Recovery through Integrated Physical Activity and Behavioral Interventions: A Comprehensive Approach to Treatment and Prevention

Brain Sciences, Год журнала: 2024, Номер 14(6), С. 534 - 534

Опубликована: Май 24, 2024

The global issue of substance abuse demands ongoing initiatives aligned with the United Nations Sustainable Development Goals. With drug use remaining prevalent worldwide, interventions are critical to addressing associated health challenges and societal implications. Exercise physical activities have emerged as integral components disorder (SUD) treatment, offering promising avenues for prevention, intervention, recovery. Recent research underscores efficacy exercise in reducing cravings, promoting abstinence, improving overall well-being. However, integrating into SUD recovery programs presents such dropout rates cultural considerations. This paper synthesizes existing literature on integration recovery, highlighting strategies enhancing treatment outcomes barriers adherence. Drawing cognitive–behavioral therapy, experiential learning, motivational interviewing, goal-setting techniques, holistic approach outlined this aims empower individuals both mentally physically, fostering resilience supporting long-term In conclusion, new need be taken by advocating inclusive policies, community engagement, collaborations across sectors. By doing so, stakeholders can optimize effectiveness contribute sustainable rehabilitation efforts SUD.

Язык: Английский

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Pharmacological treatment for substance use disorder: A systematic review

Addictive Behaviors, Год журнала: 2025, Номер 163, С. 108242 - 108242

Опубликована: Янв. 2, 2025

Язык: Английский

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The Rise of Fentanyl: Molecular Aspects and Forensic Investigations

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 444 - 444

Опубликована: Янв. 7, 2025

Fentanyl is a synthetic opioid widely used for its potent analgesic effects in chronic pain management and intraoperative anesthesia. However, high potency, low cost, accessibility have also made it significant drug of abuse, contributing to the global epidemic. This review aims provide an in-depth analysis fentanyl's medical applications, pharmacokinetics, metabolism, pharmacogenetics while examining adverse forensic implications. Special attention given misuse, polydrug interactions, challenges determining cause death fentanyl-related fatalities. misuse has escalated dramatically, driven by substitution heroin availability through online platforms, including dark web. Polydrug use, where fentanyl combined with substances like xylazine, alcohol, benzodiazepines, or cocaine, exacerbates toxicity increases risk fatal outcomes. undergoes rapid distribution, metabolism CYP3A4 into inactive metabolites, renal excretion. Genetic polymorphisms CYP3A4, OPRM1, ABCB1 significantly influence individual responses fentanyl, affecting efficacy potential toxicity. Fentanyl's side include respiratory depression, cardiac arrhythmias, gastrointestinal dysfunction, neurocognitive impairments. Chronic disrupts brain function, contributes mental health disorders, poses risks younger older populations alike. Fentanyl-related deaths require comprehensive investigations, judicial inspections, autopsies, toxicological analyses. Additionally, co-administration xylazine presents distinct scientific community. Histological immunohistochemical studies are essential understanding organ-specific damage, pharmacogenetic testing can identify susceptibilities. The growing prevalence abuse highlights need robust protocols, advanced research variability, strategies mitigate misuse. International collaboration, public education, harm reduction measures critical addressing crisis effectively.

Язык: Английский

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Polymer-Based Vaccines for Substance Use Disorders: Targeting Ketamine and Methamphetamine with Protein-Free Hyperbranched Polyethyleneimine Carriers

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 285, С. 117274 - 117274

Опубликована: Янв. 11, 2025

Язык: Английский

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Echocardiography with Strain Assessment in Psychiatric Diseases: A Narrative Review

Diagnostics, Год журнала: 2025, Номер 15(3), С. 239 - 239

Опубликована: Янв. 21, 2025

Mental disorders (MDs) are among the major causes of morbidity and mortality worldwide. Individuals with severe MDs have a shorter life expectancy, primarily due to cardiovascular diseases. Echocardiography facilitates evaluation alterations in cardiac morphology function, resulting from various pathologies. The aim this review was explore current evidence base behind myocardial deformation observed echocardiography patients MDs. We focused on data regarding speckle tracking echocardiography. PubMed, using medical subject headings, searched identify studies topic. collected demonstrated changes function schizophrenia, bipolar disorder, depression, anxiety stressor-related post-traumatic stress eating disorders, sleep–wake substance-related addictive neurocognitive borderline personality disorder. recurrent findings included impaired Left Ventricular Ejection Fraction Hypertrophy. Global Longitudinal Strain significantly altered anorexia nervosa, disorders. All reported support consideration cardiology consultations multidisciplinary approach care suspected dysfunction. Further investigation is warranted determine significance prognostic value strain measurements individuals MDs, focusing early detection, especially asymptomatic cases.

Язык: Английский

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Unveiling the Complexities of Medications, Substance Abuse, and Plants for Recreational and Narcotic Purposes: An In-Depth Analysis

Pharmacy, Год журнала: 2025, Номер 13(1), С. 7 - 7

Опубликована: Янв. 22, 2025

The complexities surrounding the use of medications, substance abuse, and recreational plants are multifaceted warrant a comprehensive examination. This review highlights consumption chemical substances in excess or for non-medical purposes, obtained through legal prescriptions, over-the-counter purchases, illicit means, with an emphasis on predictive role stressors individual-level variables development disorders, as well influence regulatory environment patterns consumption. Additionally, alarming escalation mortality rate associated drug opioid overdoses is also underscored. prescription medications can lead to significant health risks, particularly when combined other substances; therefore, need interventions preventive measures address abuse among various populations imperative. Furthermore, novel insights addiction, exploring neurobiological mechanisms underlying discussing treatment approaches elucidated. Advancements technology detecting highlighted, displaying innovative tools more effective identification monitoring. In conclusion, reveal landscape marked by overlapping motivations implications. distinction between medical critical understanding user behavior addressing public concerns.

Язык: Английский

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