Antecedents of major depressive, bipolar, and psychotic disorders: A systematic review and meta-analysis of prospective studies

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 160, С. 105625 - 105625

Опубликована: Март 15, 2024

Язык: Английский

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The lived experience of mental disorders in adolescents: a bottom‐up review co‐designed, co‐conducted and co‐written by experts by experience and academics

World Psychiatry, Год журнала: 2024, Номер 23(2), С. 191 - 208

Опубликована: Май 10, 2024

We provide here the first bottom-up review of lived experience mental disorders in adolescents co-designed, co-conducted and co-written by experts academics. screened first-person accounts within outside medical field, discussed them collaborative workshops involving numerous - representing different genders, ethnic cultural backgrounds, continents their family members carers. Subsequently, material was enriched phenomenologically informed perspectives shared with all collaborators. The inner subjective is described for mood disorders, psychotic attention-deficit/hyperactivity disorder, autism spectrum anxiety eating externalizing self-harm behaviors. recollection individuals' past histories also indexes prodromal (often transdiagnostic) features predating psychiatric diagnosis. wider society respect to family, school peers, social context. Furthermore, health care receiving a diagnosis accessing support, psychopharmacological treatment, psychotherapy, experiencing peer support activism, achieving recovery. These findings can impact clinical practice, research, whole society. hope that this journey help us maintain our commitment protecting adolescents' fragile health, develop into healthy, fulfilling contributing adult life.

Язык: Английский

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Eating disorders: etiology, risk factors, and suggestions for prevention

Current Opinion in Psychiatry, Год журнала: 2024, Номер 37(6), С. 381 - 387

Опубликована: Авг. 22, 2024

The incidence of eating disorders has increased worldwide. This narrative review gives an overview research on etiology and risk factors published in 2022-2024.

Язык: Английский

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Development and Predictors of Bipolar Disorder in Children and Adolescents with Depressive Disorders A Systematic Review, Meta-analysis and Meta-regression

European Psychiatry, Год журнала: 2025, Номер unknown, С. 1 - 37

Опубликована: Янв. 8, 2025

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Язык: Английский

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Sensitivity of the clinical high-risk and familial high-risk approaches for psychotic disorders – a systematic review and meta-analysis

Psychological Medicine, Год журнала: 2025, Номер 55

Опубликована: Янв. 1, 2025

Abstract Background Psychosis prediction has been a key focus of psychiatry research for over 20 years. The two dominant approaches to identifying psychosis risk have the clinical high-risk (CHR) and familial (FHR) approaches. To date, real-world sensitivity these – that is, proportion all future psychotic disorders in population they identify not systematically reviewed. Methods We reviewed meta-analysed studies MEDLINE, Embase, PsychINFO, Web Science (from inception until September 2024) reported data on CHR FHR i.e., individuals with diagnosis preceded by or history parental (PROSPERO: CRD42024542268). Results identified four reporting relevant data. pooled estimate approach was 6.7% (95% CI: 1.5–15.0%) 6.5% 4.4–8.9%). There high level heterogeneity between studies. Most had low bias, but most bias. Conclusion Pooled suggest approaches, each, capture only about 6–7% disorders. These findings demonstrate need additional psychosis.

Язык: Английский

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Risk of Psychosis Among Individuals Who Have Presented to Hospital With Self-harm: A Prospective Nationwide Register Study in Sweden

Schizophrenia Bulletin, Год журнала: 2024, Номер 50(4), С. 881 - 890

Опубликована: Янв. 19, 2024

Abstract Background and Hypothesis Recent research showed that young people who presented to hospital with self-harm in Finland had a significantly elevated risk of later psychosis. We investigated the prospective relationship between presentation for psychosis an unprecedentedly large national Swedish cohort. Study Design used inpatient outpatient healthcare registers identify all individuals born 1981 1993 were alive living Sweden on their 12th birthday one or more times self-harm. compared them matched cohort, followed up 20 years, cumulative incidence psychotic disorders. Furthermore, we examined whether strength changed over time by examining cohort effects. Results In total, 28 908 (2.0%) without prior diagnosis during follow-up. For self-harm, diagnosed was 20.7% at years follow-up (hazard radio = 13.9, 95% CI 13.3–14.6, P-value <5 × 10−308). There no evidence dilution effect time: while increased, this did not result attenuation subsequent Conclusions Individuals present teens 20s represent important group prediction prevention.

Язык: Английский

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Duration of Untreated Illness in Patients with Obsessive–Compulsive Disorder and Its Impact on Long-Term Outcome: A Systematic Review

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(10), С. 1453 - 1453

Опубликована: Сен. 29, 2023

Background: Duration of untreated illness (DUI)—defined as the time period between onset a mental disorder and its first adequate treatment—should influence patients’ long-term prognosis outcome. In patients with obsessive–compulsive (OCD), DUI lasts on average from 87.5 up to 94.5 months, being significantly longer compared data available affected by other severe disorders, such schizophrenia bipolar disorder. We carried out systematic review in order assess impact outcomes OCD patients. Methods: A systemic has been implemented, searching inception April 2023; only papers written English were included. Results: Seventy-one articles initially identified; eight included review. The ranged 7.0 ± 8.5 20.9 11.2 years. Patients reporting have poor outcome terms lower level treatment response greater symptom severity. Conclusions: present confirms that negative OCD. It should be useful promote dissemination early interventions specific focus symptoms.

Язык: Английский

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Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task‐based fMRI connectome study

Journal of Child Psychology and Psychiatry, Год журнала: 2024, Номер 65(8), С. 1072 - 1086

Опубликована: Янв. 14, 2024

Background Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and developing side effects after antidepressant exposure. The neurobiological basis these risks remains poorly understood. We aimed to identify biomarkers underlying by characterizing abnormalities in the brain connectome symptomatic youth familial BD. Methods Depressed and/or anxious ( n = 119, age 14.9 ± 1.6 years) BD but no prior exposure typically controls 57, 14.8 1.7 received functional magnetic resonance imaging (fMRI) during an emotional continuous performance task. A generalized psychophysiological interaction (gPPI) analysis was performed compare their patterns, followed machine learning topological metrics. Results High‐risk showed weaker connectivity patterns that were mainly located default mode network (DMN) (network weight 50.1%) relative controls, derived from visual (VN) constituted largest proportion aberrant stronger pairs 54.9%). Global local efficiency E , p .022) clustering coefficient C .029) nodal metrics right superior frontal gyrus (SFG) : < .001; .001) high‐risk group significantly higher than those healthy subjects, similar also found left insula (degree: .004; betweenness: .005; age‐by‐group interaction, .038) hippocampus .003; .003). case–control classifier achieved cross‐validation accuracy 78.4%. Conclusions Our findings abnormal organization DMN VN advance mechanistic understanding Neuroimaging segregation SFG altered centrality broader limbic systems used target interventions tailored mitigate at‐risk youth.

Язык: Английский

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Sensitivity of the familial high‐risk approach for the prediction of future psychosis: a total population study

World Psychiatry, Год журнала: 2024, Номер 23(3), С. 432 - 437

Опубликована: Сен. 16, 2024

Children who have a parent with psychotic disorder present an increased risk of developing psychosis. It is unclear to date, however, what proportion all psychosis cases in the population are captured by familial high‐risk for (FHR‐P) approach. This essential information prevention research and health service planning, as it tells us total that this approach would prevent if effective intervention were developed. Through prospective cohort study including individuals born Finland between January 1, 1987 December 31, 1992, we examined absolute FHR‐P transdiagnostic (TDFR‐P) based on parental inpatient hospitalization any mental disorder. Outcomes non‐affective (ICD‐10: F20‐F29) schizophrenia F20) identified index children up 2016. Of (N=368,937), 1.5% (N=5,544) met criteria 10.3% (N=38,040) TDFR‐P criteria. By endpoint, 1.9% (N=6,966) had been diagnosed 0.5% (N=1,846) schizophrenia. In terms sensitivity, children, 5.2% (N=355) 20.6% (N=1,413) approaches. The was 6.4% those FHR‐P, 3.7% TDFR‐P. There notable variation sensitivity age at which FHR‐P/TDFR‐P determined. psychosis, relatively time invariant. These metrics inform strategies requiring pragmatic decision‐making.

Язык: Английский

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Early risk identification and prevention of bipolar disorder: ethical considerations and user perspectives

Biological Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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