Obsessive–Compulsive Symptoms in the General Population Under Stressful Conditions: Lessons Learned from the COVID-19 Pandemic DOI Creative Commons
Luca Pellegrini, Umberto Albert, Claudia Carmassi

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(12), С. 1280 - 1280

Опубликована: Дек. 19, 2024

Introduction: The COVID-19 pandemic had a negative impact on mental health in the general population. fear, stress, and uncertainty surrounding that traumatic period could have contributed to aggravation or possible new onset of obsessive–compulsive symptoms. Methods: COvid Mental hEalth Trial (COMET) is nationwide project organized by University Campania “Luigi Vanvitelli”, designed as an observational investigation aimed gather data from representative sample Italian current study report main it focuses (OC) Results: A total N = 20,720 took part survey. 2332 individuals Obsessive–Compulsive Inventory—Revised (OCI-R) score greater than equal 21 (11.3% entire sample), indicating presence clinically relevant By excluding patients with history previous illnesses, we still obtained high number OCI-R (N 2024), representing 10.3% overall sample, possibly incidence OC symptoms during pandemic. Discussion: Our highlights substantial public. Risk factors red flags such being male, working age, living highly stressful environment one regions most affected severely hit pandemic, having higher levels loneliness, using substances cope should be paid particular attention order prevent development critical event

Язык: Английский

Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum DOI Creative Commons
Xiaotao Liang,

Yuewen Ding,

Xiaoyu Zhu

и другие.

Translational Psychiatry, Год журнала: 2025, Номер 15(1)

Опубликована: Март 21, 2025

The circadian rhythm system consists of a master clock located in the suprachiasmatic nucleus (SCN) hypothalamus and peripheral clocks dispersed throughout other brain areas (including striatum, Str) as well various tissues organs. Circadian disturbance is major risk factor common comorbidity for mood disorders, especially anxiety depression. Bmal1 one fundamental protein genes that required to maintain rhythm. Recent research has revealed link between dysfunction depression, but underlying mechanisms remain be fully elucidated. This study aimed investigate how may lead anxiety- depression-like behaviors. Through behavioral tests, virus tracing, molecular biology techniques, we found neural connection from striatum. SCN lesions Bmal1flox/flox + pAAV-hSyn-Cre-GFP (conditional knockout, cKO) mice exhibited disruptions core body temperature rhythm, Importantly, these displayed altered expression patterns an upregulation Brain-Derived Neurotrophic Factor (BDNF) - Tyrosine Kinase receptor B (TrkB) signaling pathway within Microinjection TrkB inhibitor ANA-12 can effectively reverse These findings indicate contribute pathogenesis depression through BDNF-TrkB potentially mediated by projections SCN. gene represent novel therapeutic target disorders.

Язык: Английский

Процитировано

2
Neurotransmitter Modulation of Sleep-Wake States: From Molecular Mechanisms to Therapeutic Potential DOI
Xinyi Ye, Shuchao Pang, Xiaoyong Ren

и другие.

Sleep Medicine, Год журнала: 2025, Номер 132, С. 106547 - 106547

Опубликована: Май 8, 2025

Язык: Английский

Процитировано

0
Factors Associated with Anxiety, Depression, and Quality of Life in Patients with Psoriasis: A Cross-Sectional Study DOI Creative Commons
Salvatore Cipolla, Pierluigi Catapano,

Antonio Fiorino Bonamico

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(9), С. 865 - 865

Опубликована: Авг. 27, 2024

Background: Psoriasis is a chronic skin disorder affecting 2–3% of the global population, and associated with several comorbidities, including psychiatric disorders. This study aimed to identify factors influencing anxiety, depression, quality life (QoL) in patients psoriasis. Methods: observational included 112 diagnosed Dermatological assessments were conducted using Psodisk, Hamilton Anxiety Rating Scale (HAM-A), Depression (HAM-D), Symptom Checklist-90-Revised (SCL-90-R), 36-Item Short Form Health Survey (SF-36). Descriptive statistics, correlation analyses, multivariate regression models employed. Results: The sample was predominantly middle-aged males (mean age 48.91 years). Females (p < 0.001), arthritis 0.05), those sedentary lifestyle 0.05) showed higher anxiety depression scores. Psodisk subscales significantly correlated symptoms QoL measures 0.001). Pain (B: 0.63, p 0.05; B: −2.03, 0.01) sleep disturbances 0.68, 0.01; 0.60, −1.46, −1.57, 3.91, emerged as major predictors poor mental health reduced QoL. Conclusions. underscores complex relationship between psoriasis, Key exacerbating include female gender, arthritis, lifestyle. Comprehensive management psoriasis should address both dermatological psychological aspects, focus on pain relief improving enhance overall patient well-being.

Язык: Английский

Процитировано

3
Incorporating Complexity and System Dynamics into Economic Modelling for Mental Health Policy and Planning DOI Creative Commons
Paul Crosland, Deborah A. Marshall, Seyed Hossein Hosseini

и другие.

PharmacoEconomics, Год журнала: 2024, Номер 42(12), С. 1301 - 1315

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

2
Evening Chronotypes With Depression Report Poorer Outcomes of Selective Serotonin Reuptake Inhibitors: A Survey-Based Study of Self-Ratings DOI Creative Commons
Jacob J. Crouse, Shin Park, Enda M. Byrne

и другие.

Biological Psychiatry, Год журнала: 2024, Номер 96(1), С. 4 - 14

Опубликована: Янв. 5, 2024

Background Preliminary evidence suggests evening chronotype relates to poorer efficacy of selective-serotonin reuptake inhibitors (SSRIs). It is unknown whether this specific particular medications, self-rated chronotype, or efficacy. Methods In the Australian Genetics Depression Study (N=15,108; 75% female; 18-90 years; 68% with ≥1 other lifetime diagnosis), a survey assessed experiences 10 antidepressants and reduced Morningness-Evening Questionnaire; polygenic score (PGS) was calculated. Age- sex-adjusted regression models (Bonferroni-corrected) estimated associations among variables ("how well antidepressant worked" [efficacy], duration symptom improvement, side effects, discontinuation due effects) genetic chronotypes. Results The chronotype-PGS explained 4% variance in (r=0.21). Higher eveningness associated escitalopram (OR=1.04; 95% CI 1.02-1.06; p=0.000035), fluoxetine (OR=1.03; 1.01-1.05; p=0.001), sertraline (OR=1.02; 1.01-1.04; p=0.0008), desvenlafaxine p=0.004), profile increased effects (80% those recorded; ORs=0.93-0.98), 'difficulty getting sleep' most likely. Self-rated not related improvement effects. only suicidal thoughts attempted suicide (self-reported). While our measures are imperfect, circadian phase under controlled conditions, model coefficients suggest that dysregulation phenotypic relative its proxy driving relationships outcomes. Conclusions idea variation factors influences responses supported encourages exploration mechanisms depressive disorders treatments.

Язык: Английский

Процитировано

1
THE EXERCISE OF PUBLIC HEALTH POWERS IN MENTAL HEALTHCARE - THE IMPACT ON PUBLIC SAFETY DOI Open Access
Marina Losevich,

K. I. Konstantinova

SOCIETY INTEGRATION EDUCATION Proceedings of the International Scientific Conference, Год журнала: 2024, Номер 2, С. 649 - 667

Опубликована: Май 22, 2024

To ensure public safety, most European states have statutory powers enabling a range of compulsory interventions for persons with infectious diseases and mental disorders. The evidence their meaningfulness in health patients is dubious, especially regarding preventive effect on safety. reveal the services' impact violent offense commissions after discharge from involuntary inpatient care, retrospective three-case series study was conducted. A scoping literature review performed to construct recommendations practice improvement further studies. Based individual clinical expertise, common issues delivering healthcare Latvia are described. conclude, coercive psychiatric shall be considered as part internal security human rights protection and, therefore, surveilled, line communicable diseases. Legal mechanisms (temporary against violence, measures medical nature) not effective severe illness fail prevent incidents. By time being, during admission treatment, patient subjected various safety risks, that inconsistent basic or best interests, thus determines state's obligation promote voluntary treatment provide least restrictive approach.

Язык: Английский

Процитировано

0
Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum DOI
Wei Xie,

Lai Xiao-tao,

Yuewen Ding

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 11, 2024

Abstract The circadian rhythm system consists of a master clock located in the suprachiasmatic nucleus (SCN) hypothalamus and peripheral clocks dispersed throughout other brain areas (including striatum, Str) as well various tissues organs. Circadian disturbance is major risk factor common comorbidity for mood disorders, especially anxiety depression. Bmal1 one fundamental protein genes that required to maintain rhythm. Recent research has revealed link between dysfunction depression, but underlying mechanisms remain be fully elucidated. This study aimed investigate how may lead depression-like behaviors. Through behavioral tests, virus tracing, molecular biology techniques, we found neural connection from striatum. SCN lesions Bmal1flox/flox+pAAV-hSyn-Cre-GFP (conditional knockout, cKO) mice exhibited disruptions core body temperature rhythm, anxiety- Importantly, these displayed altered expression patterns an upregulation Brain-Derived Neurotrophic Factor (BDNF) - Tyrosine Kinase receptor B (TrkB) signaling pathway within Microinjection TrkB inhibitor ANA-12 can effectively reverse These findings indicate contribute pathogenesis depression through BDNF-TrkB potentially mediated by projections SCN. gene represent novel therapeutic target disorders.

Язык: Английский

Процитировано

0
Obsessive–Compulsive Symptoms in the General Population Under Stressful Conditions: Lessons Learned from the COVID-19 Pandemic DOI Creative Commons
Luca Pellegrini, Umberto Albert, Claudia Carmassi

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(12), С. 1280 - 1280

Опубликована: Дек. 19, 2024

Introduction: The COVID-19 pandemic had a negative impact on mental health in the general population. fear, stress, and uncertainty surrounding that traumatic period could have contributed to aggravation or possible new onset of obsessive–compulsive symptoms. Methods: COvid Mental hEalth Trial (COMET) is nationwide project organized by University Campania “Luigi Vanvitelli”, designed as an observational investigation aimed gather data from representative sample Italian current study report main it focuses (OC) Results: A total N = 20,720 took part survey. 2332 individuals Obsessive–Compulsive Inventory—Revised (OCI-R) score greater than equal 21 (11.3% entire sample), indicating presence clinically relevant By excluding patients with history previous illnesses, we still obtained high number OCI-R (N 2024), representing 10.3% overall sample, possibly incidence OC symptoms during pandemic. Discussion: Our highlights substantial public. Risk factors red flags such being male, working age, living highly stressful environment one regions most affected severely hit pandemic, having higher levels loneliness, using substances cope should be paid particular attention order prevent development critical event

Язык: Английский

Процитировано

0