Shining a Spotlight on RNA m6A Modifications and Potential Targeted Immunotherapy in Ovarian Cancer DOI Creative Commons

Huishen Pang,

Weiping Zheng,

Qiyun Lu

и другие.

Clinical and Experimental Obstetrics & Gynecology, Год журнала: 2024, Номер 51(12)

Опубликована: Дек. 23, 2024

Objective: Ovarian cancer is one of the major gynecologic malignancies worldwide. Evidence indicates that N6-methyladenosine (m6A) modification strongly related to immunity. This review aims demonstrate role and function m6A in ovarian tumorigenesis its potential targeted immunotherapy. Mechanism: Searching literature for articles Conducting a comprehensive analysis summarizing content logically. Findings Brief: In this review, we summarized latest research on regulators Firstly, found underlying molecular mechanism (writers, erasers readers) development progress cancer. Then, discovered play pivotal immune responses efficacy, serving as therapeutic targets Additionally, long noncoding RNAs (lncRNAs) have strong impact survival Finally, deeply analyzing genes are needed improve immunotherapy Conclusions: has carcinogenesis

Язык: Английский

Writers, readers, and erasers RNA modifications and drug resistance in cancer DOI Creative Commons
Di Chen, Xinyu Gu,

Yeltai Nurzat

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 30, 2024

Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to recurrence and metastasis. A critical factor contributing this is the epigenetic alteration of gene expression via RNA modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), pseudouridine (Ψ), adenosine-to-inosine (A-to-I) editing. These modifications are pivotal regulating splicing, translation, transport, degradation, stability. Governed by "writers," "readers," "erasers," impact numerous biological processes progression, including cell proliferation, stemness, autophagy, invasion, apoptosis. Aberrant can lead drug adverse outcomes various cancers. Thus, targeting modification regulators offers a promising strategy for overcoming enhancing efficacy. This review consolidates recent research on role prevalent resistance, with focus m6A, m1A, m5C, m7G, Ψ, A-to-I Additionally, it examines regulatory mechanisms linked underscores existing limitations field.

Язык: Английский

Процитировано

19

TRMT10C gene polymorphisms confer hepatoblastoma susceptibility: evidence from a seven-center case-control study DOI Creative Commons

Yanfei Liu,

Jinhong Zhu, Xian-Qiang Wang

и другие.

Journal of Cancer, Год журнала: 2024, Номер 15(16), С. 5396 - 5402

Опубликована: Янв. 1, 2024

N1-methyladenosine (m

Процитировано

3

The role of m5C RNA modification in cancer development and therapy DOI Creative Commons

Li Yu,

Hongen Xu, Hanchu Xiong

и другие.

Heliyon, Год журнала: 2024, Номер 10(19), С. e38660 - e38660

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

3

NAT10 promotes ovarian cancer cell migration, invasion, and stemness via N4-acetylcytidine modification of CAPRIN1 DOI Creative Commons
Yang Song, Min Cheng

BMC Women s Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 8, 2025

Ovarian cancer (OC) is the most lethal gynecological tumor. N4-acetylcytidine (ac4C) modification, catalyzed by acetyltransferase NAT10, involved in occurrence and development of cancers. This study aimed to investigate role NAT10 OC underlying molecular mechanisms. The expression CAPRIN1 cells lines were measured using quantitative real-time polymerase chain reaction immunoblotting. Biological behaviors evaluated EdU, Transwell, sphere formation, immunoblotting assays. mechanism function was analyzed bioinformatics, ac4C- RNA immunoprecipitation, actinomycin D treatment assay. effect on progression vivo xenograft tumor model. results indicated that highly expressed cells. knockdown suppressed cell proliferation, migration, invasiveness, stemness, epithelial-mesenchymal transition vitro, impeded growth vivo. Additionally, found be positively related OC. Silencing inhibited ac4C levels reduced its stability. Moreover, overexpression reversed suppression invasion, stemness caused knockdown, while alone these malignant In conclusion, promotes promoting cellular via upregulating expression. Mechanistically, stabilizes modification. These findings suggest may a promising therapy target for

Язык: Английский

Процитировано

0

The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer DOI Creative Commons

Qiu Li,

Shourong Wu, Lei Zhang

и другие.

Genes & Diseases, Год журнала: 2025, Номер unknown, С. 101567 - 101567

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

FTO triggers NLRP3/GSDMD-dependent pyroptosis to enhance cisplatin-sensitivity in ovarian cancer DOI
Fubin Zhang,

Tianhong Zhu,

Lei Gan

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111698 - 111698

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

RNA Modification in Metabolism DOI Creative Commons
Yadi Liu,

Zhongyan Sun,

Dingkun Gui

и другие.

MedComm, Год журнала: 2025, Номер 6(3)

Опубликована: Март 1, 2025

ABSTRACT Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and most prevalent modification N6‐methyladenosine (m 6 A). Recently, emerged as a potential target for treatment. posttranscriptional gene expression that involved both physiological pathological processes. Evidence suggests m A significantly affects metabolism, its abnormal changes have observed variety diseases. Metabolic diseases are series caused by metabolic processes body, common include diabetes mellitus, obesity, nonalcoholic fatty liver disease, etc.; although pathogenesis these differs from each other to current understanding, recent studies suggested pivotal role modulating diseases, A‐based drug on agenda. This paper reviewed understanding hoping provide systematic information those area.

Язык: Английский

Процитировано

0

Surface-Enhanced Raman Spectroscopy (SERS) for the Characterization of the Blood Serum Samples of Ovarian Cancer DOI

Saima Aziz,

Noor ul Huda, Haq Nawaz

и другие.

Plasmonics, Год журнала: 2025, Номер unknown

Опубликована: Май 6, 2025

Язык: Английский

Процитировано

0

Circular RNAs in gynecologic cancers: mechanisms and implications for chemotherapy resistance DOI Creative Commons
Meiying Qin, Chunmei Zhang, Li Yang

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Июнь 8, 2023

Chemotherapy resistance remains a major challenge in the treatment of gynecologic malignancies. Increasing evidence suggests that circular RNAs (circRNAs) play significant role conferring chemoresistance these cancers. In this review, we summarize current understanding mechanisms by which circRNAs regulate chemotherapy sensitivity and We also discuss potential clinical implications findings highlight areas for future research. CircRNAs are novel class RNA molecules characterized their unique structure, confers increased stability to degradation exonucleases. Recent studies have shown can act as miRNA sponges, sequestering miRNAs preventing them from binding target mRNAs. This lead upregulation genes involved drug pathways, ultimately resulting decreased chemotherapy. several specific examples been implicated cancers, including cervical cancer, ovarian endometrial cancer. applications circRNA-based biomarkers predicting response guiding decisions. Overall, review provides comprehensive overview state knowledge regarding By elucidating underlying sensitivity, work has important improving patient outcomes developing more effective therapeutic strategies challenging

Язык: Английский

Процитировано

8

RNA epigenetic modifications in digestive tract cancers: Friends or foes DOI Creative Commons

Zekai Nian,

Ming Deng, Lele Ye

и другие.

Pharmacological Research, Год журнала: 2024, Номер 206, С. 107280 - 107280

Опубликована: Июнь 22, 2024

Digestive tract cancers are among the most common malignancies worldwide and have high incidence mortality rates. Thus, discovery of more effective diagnostic therapeutic targets is urgently required. The development technologies to accurately detect RNA modification has led identification numerous chemical modifications in humans (epitranscriptomics) that involved occurrence digestive cancers. can cooperatively regulate gene expression facilitate normal physiological functions system. However, dysfunction relevant RNA-modifying enzymes ("writers," "erasers," "readers") lead Consequently, targeting dysregulated enzyme activity could represent a potent strategy for treatment In this review, we summarize widely studied roles mechanisms (m6A, m1A, m5C, m7G, A-to-I editing, pseudouridine [Ψ]) relation cancers, highlight crosstalk between modifications, discuss their interactions system microbiota during carcinogenesis. clinical significance novel methods based on also discussed. This review will help guide future research into resistant current therapeutics.

Язык: Английский

Процитировано

3