Clinical and Experimental Obstetrics & Gynecology,
Год журнала:
2024,
Номер
51(12)
Опубликована: Дек. 23, 2024
Objective:
Ovarian
cancer
is
one
of
the
major
gynecologic
malignancies
worldwide.
Evidence
indicates
that
N6-methyladenosine
(m6A)
modification
strongly
related
to
immunity.
This
review
aims
demonstrate
role
and
function
m6A
in
ovarian
tumorigenesis
its
potential
targeted
immunotherapy.
Mechanism:
Searching
literature
for
articles
Conducting
a
comprehensive
analysis
summarizing
content
logically.
Findings
Brief:
In
this
review,
we
summarized
latest
research
on
regulators
Firstly,
found
underlying
molecular
mechanism
(writers,
erasers
readers)
development
progress
cancer.
Then,
discovered
play
pivotal
immune
responses
efficacy,
serving
as
therapeutic
targets
Additionally,
long
noncoding
RNAs
(lncRNAs)
have
strong
impact
survival
Finally,
deeply
analyzing
genes
are
needed
improve
immunotherapy
Conclusions:
has
carcinogenesis
Drug
resistance
in
cancer
cells
significantly
diminishes
treatment
efficacy,
leading
to
recurrence
and
metastasis.
A
critical
factor
contributing
this
is
the
epigenetic
alteration
of
gene
expression
via
RNA
modifications,
such
as
N6-methyladenosine
(m6A),
N1-methyladenosine
(m1A),
5-methylcytosine
(m5C),
7-methylguanosine
(m7G),
pseudouridine
(Ψ),
adenosine-to-inosine
(A-to-I)
editing.
These
modifications
are
pivotal
regulating
splicing,
translation,
transport,
degradation,
stability.
Governed
by
"writers,"
"readers,"
"erasers,"
impact
numerous
biological
processes
progression,
including
cell
proliferation,
stemness,
autophagy,
invasion,
apoptosis.
Aberrant
can
lead
drug
adverse
outcomes
various
cancers.
Thus,
targeting
modification
regulators
offers
a
promising
strategy
for
overcoming
enhancing
efficacy.
This
review
consolidates
recent
research
on
role
prevalent
resistance,
with
focus
m6A,
m1A,
m5C,
m7G,
Ψ,
A-to-I
Additionally,
it
examines
regulatory
mechanisms
linked
underscores
existing
limitations
field.
BMC Women s Health,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 8, 2025
Ovarian
cancer
(OC)
is
the
most
lethal
gynecological
tumor.
N4-acetylcytidine
(ac4C)
modification,
catalyzed
by
acetyltransferase
NAT10,
involved
in
occurrence
and
development
of
cancers.
This
study
aimed
to
investigate
role
NAT10
OC
underlying
molecular
mechanisms.
The
expression
CAPRIN1
cells
lines
were
measured
using
quantitative
real-time
polymerase
chain
reaction
immunoblotting.
Biological
behaviors
evaluated
EdU,
Transwell,
sphere
formation,
immunoblotting
assays.
mechanism
function
was
analyzed
bioinformatics,
ac4C-
RNA
immunoprecipitation,
actinomycin
D
treatment
assay.
effect
on
progression
vivo
xenograft
tumor
model.
results
indicated
that
highly
expressed
cells.
knockdown
suppressed
cell
proliferation,
migration,
invasiveness,
stemness,
epithelial-mesenchymal
transition
vitro,
impeded
growth
vivo.
Additionally,
found
be
positively
related
OC.
Silencing
inhibited
ac4C
levels
reduced
its
stability.
Moreover,
overexpression
reversed
suppression
invasion,
stemness
caused
knockdown,
while
alone
these
malignant
In
conclusion,
promotes
promoting
cellular
via
upregulating
expression.
Mechanistically,
stabilizes
modification.
These
findings
suggest
may
a
promising
therapy
target
for
ABSTRACT
Epigenetic
regulation
in
disease
development
has
been
witnessed
within
this
decade.
RNA
methylation
is
the
predominant
form
of
epigenetic
regulation,
and
most
prevalent
modification
N6‐methyladenosine
(m
6
A).
Recently,
emerged
as
a
potential
target
for
treatment.
posttranscriptional
gene
expression
that
involved
both
physiological
pathological
processes.
Evidence
suggests
m
A
significantly
affects
metabolism,
its
abnormal
changes
have
observed
variety
diseases.
Metabolic
diseases
are
series
caused
by
metabolic
processes
body,
common
include
diabetes
mellitus,
obesity,
nonalcoholic
fatty
liver
disease,
etc.;
although
pathogenesis
these
differs
from
each
other
to
current
understanding,
recent
studies
suggested
pivotal
role
modulating
diseases,
A‐based
drug
on
agenda.
This
paper
reviewed
understanding
hoping
provide
systematic
information
those
area.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 8, 2023
Chemotherapy
resistance
remains
a
major
challenge
in
the
treatment
of
gynecologic
malignancies.
Increasing
evidence
suggests
that
circular
RNAs
(circRNAs)
play
significant
role
conferring
chemoresistance
these
cancers.
In
this
review,
we
summarize
current
understanding
mechanisms
by
which
circRNAs
regulate
chemotherapy
sensitivity
and
We
also
discuss
potential
clinical
implications
findings
highlight
areas
for
future
research.
CircRNAs
are
novel
class
RNA
molecules
characterized
their
unique
structure,
confers
increased
stability
to
degradation
exonucleases.
Recent
studies
have
shown
can
act
as
miRNA
sponges,
sequestering
miRNAs
preventing
them
from
binding
target
mRNAs.
This
lead
upregulation
genes
involved
drug
pathways,
ultimately
resulting
decreased
chemotherapy.
several
specific
examples
been
implicated
cancers,
including
cervical
cancer,
ovarian
endometrial
cancer.
applications
circRNA-based
biomarkers
predicting
response
guiding
decisions.
Overall,
review
provides
comprehensive
overview
state
knowledge
regarding
By
elucidating
underlying
sensitivity,
work
has
important
improving
patient
outcomes
developing
more
effective
therapeutic
strategies
challenging
Pharmacological Research,
Год журнала:
2024,
Номер
206, С. 107280 - 107280
Опубликована: Июнь 22, 2024
Digestive
tract
cancers
are
among
the
most
common
malignancies
worldwide
and
have
high
incidence
mortality
rates.
Thus,
discovery
of
more
effective
diagnostic
therapeutic
targets
is
urgently
required.
The
development
technologies
to
accurately
detect
RNA
modification
has
led
identification
numerous
chemical
modifications
in
humans
(epitranscriptomics)
that
involved
occurrence
digestive
cancers.
can
cooperatively
regulate
gene
expression
facilitate
normal
physiological
functions
system.
However,
dysfunction
relevant
RNA-modifying
enzymes
("writers,"
"erasers,"
"readers")
lead
Consequently,
targeting
dysregulated
enzyme
activity
could
represent
a
potent
strategy
for
treatment
In
this
review,
we
summarize
widely
studied
roles
mechanisms
(m6A,
m1A,
m5C,
m7G,
A-to-I
editing,
pseudouridine
[Ψ])
relation
cancers,
highlight
crosstalk
between
modifications,
discuss
their
interactions
system
microbiota
during
carcinogenesis.
clinical
significance
novel
methods
based
on
also
discussed.
This
review
will
help
guide
future
research
into
resistant
current
therapeutics.
