A dual methodology employing ion-pair chromatography and built-in UV spectrophotometry for quantifying recently approved combination of mometasone and indacaterol in a novel combined metered dose inhaler: assessing the greenness, carbon footprint, blueness, and whiteness DOI Creative Commons
Amal A. El‐Masry, Ahmed Emad F. Abbas, Yomna A. Salem

и другие.

BMC Chemistry, Год журнала: 2024, Номер 18(1)

Опубликована: Авг. 3, 2024

Developing analytical techniques that align with green and sustainable chemistry principles is crucial in today's scientific landscape. This work introduces two innovative approaches for the simultaneous quantification of indacaterol (IND) mometasone (MOM), a recently approved combination therapy chronic obstructive pulmonary disease. These methods-rapid isocratic ion pair chromatography (IPC) UV-visible spectrophotometry-demonstrate improved environmental sustainability, cost-effectiveness, versatility compared to existing techniques. The optimized 4-min IPC method achieved excellent resolution (retention times 2.18 ± 0.1 min IND 3.95 MOM), peak symmetry, sensitivity. It utilizes low-cost mobile phase acetonitrile acidified water containing 0.025% sodium dodecyl sulfate (50:50% v/v), making it suitable laboratories standard chromatographic instruments. spectrophotometric approach offers procedures: first derivative ratio methods. serve as simplified, alternatives resource-limited without access advanced Both feature simplified protocols minimize extraction fractionation steps. Comprehensive validation confirmed outstanding accuracy (98-102%) precision (%2 <). Sustainability assessments using ComplexGAPI, AGREE, carbon footprint, BAGI, RGB12 tools demonstrated enhanced performance spectrophotometry methods greenness scores 0.81 0.85, respectively, surpassing 0.63-0.67 range reported Additionally, they showed lower footprints 0.035 0.022 kg CO2 equivalent emissions per sample, 0.079-0.092 conventional procedures. application novel "blueness" "whiteness" concepts BAGI algorithms further superior 87.5 & 90 blueness 88.1 89.8 whiteness. Successfully applied quantify MOM combined capsules, this provides model eco-friendly pharmaceutical analysis maintains high reliability while improving sustainability metrics.

Язык: Английский

A dual methodology employing ion-pair chromatography and built-in UV spectrophotometry for quantifying recently approved combination of mometasone and indacaterol in a novel combined metered dose inhaler: assessing the greenness, carbon footprint, blueness, and whiteness DOI Creative Commons
Amal A. El‐Masry, Ahmed Emad F. Abbas, Yomna A. Salem

и другие.

BMC Chemistry, Год журнала: 2024, Номер 18(1)

Опубликована: Авг. 3, 2024

Developing analytical techniques that align with green and sustainable chemistry principles is crucial in today's scientific landscape. This work introduces two innovative approaches for the simultaneous quantification of indacaterol (IND) mometasone (MOM), a recently approved combination therapy chronic obstructive pulmonary disease. These methods-rapid isocratic ion pair chromatography (IPC) UV-visible spectrophotometry-demonstrate improved environmental sustainability, cost-effectiveness, versatility compared to existing techniques. The optimized 4-min IPC method achieved excellent resolution (retention times 2.18 ± 0.1 min IND 3.95 MOM), peak symmetry, sensitivity. It utilizes low-cost mobile phase acetonitrile acidified water containing 0.025% sodium dodecyl sulfate (50:50% v/v), making it suitable laboratories standard chromatographic instruments. spectrophotometric approach offers procedures: first derivative ratio methods. serve as simplified, alternatives resource-limited without access advanced Both feature simplified protocols minimize extraction fractionation steps. Comprehensive validation confirmed outstanding accuracy (98-102%) precision (%2 <). Sustainability assessments using ComplexGAPI, AGREE, carbon footprint, BAGI, RGB12 tools demonstrated enhanced performance spectrophotometry methods greenness scores 0.81 0.85, respectively, surpassing 0.63-0.67 range reported Additionally, they showed lower footprints 0.035 0.022 kg CO2 equivalent emissions per sample, 0.079-0.092 conventional procedures. application novel "blueness" "whiteness" concepts BAGI algorithms further superior 87.5 & 90 blueness 88.1 89.8 whiteness. Successfully applied quantify MOM combined capsules, this provides model eco-friendly pharmaceutical analysis maintains high reliability while improving sustainability metrics.

Язык: Английский

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