Comprehensive Analyses Revealed Eight Immune Related Signatures Correlated With Aberrant Methylations as Prognosis and Diagnosis Biomarkers for Kidney Renal Papillary Cell Carcinoma

Clinical Genitourinary Cancer, Год журнала: 2023, Номер 21(5), С. 537 - 545

Опубликована: Июнь 23, 2023

Kidney renal papillary cell carcinoma (KIRP) is a common type of carcinoma. DNA methylation plays an important role in the development several cancers. The aim our study was to identify differentially expressed genes associated with abnormal as biomarkers for predicting outcome KIRP.We downloaded KIRP data, RNA sequencing (RNAseq) and their corresponding clinical information from Cancer Genome Atlas (TCGA) database. ChAMP DEGseq2 packages R software were used screen methylated probes (DMPs) (DEGs). Univariate multivariate Cox regression analyses suitable immune related correlated aberrant methylations prognosis biomarkers.We identified 8 DEGs (Cysteine And Glycine Rich Protein 1 [CSRP1], major histocompatibility complex, Class II, DM Beta [HLA-DMB], LIF Receptor Subunit Alpha [LIFR], Leukotriene B4 receptor 2 [LTB4R2], Mitogen-Activated Kinase 14 [MAP3K14], Nuclear Subfamily Group F Member [NR2F1], Secreted Transmembrane [SECTM1], Vimentin [VIM]) that independently overall survival (months) (OS) KIRP. time dependent area under curve (AUC) each receiver operating characteristic (ROC) risk assessment model at 1, 3, 5, 10-years reached 0.8415, 0.8131, 0.7873, 0.7667. cells factors. AUC value diagnosis using those 0.99.The constructed by well able predict diagnose However, whether could be applied practice requires further study.

Язык: Английский

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Claudin-4: A New Molecular Target for Epithelial Cancer Therapy

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5494 - 5494

Опубликована: Март 13, 2023

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 overexpressed many malignancies and correlates with cancer progression. Changes expression have been associated epigenetic factors (such as hypomethylation promoter DNA), inflammation infection cytokines, growth factor signaling. helps to maintain the tumor microenvironment by forming TJs acts barrier entry anticancer drugs into tumors. Decreased potential marker epithelial-mesenchymal transition (EMT), decreased differentiation due reduced activity involved EMT induction. Non-TJ also activates integrin beta 1 YAP promote proliferation, EMT, stemness. These roles led investigations molecular therapies targeting using anti-CLDN4 extracellular domain antibodies, gene knockdown, clostridium perfringens enterotoxin (CPE), C-terminus CPE (C-CPE), which demonstrated experimental efficacy this approach. strongly promoting malignant phenotypes cancers regarded promising therapeutic target.

Язык: Английский

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Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology

Human Reproduction Update, Год журнала: 2019, Номер 26(3), С. 423 - 449

Опубликована: Ноя. 21, 2019

Abstract BACKGROUND Endometriosis is a benign gynaecological disease. Thus, it came as complete surprise when was reported recently that the majority of deep endometriosis lesions harbour somatic mutations and sizeable portion them contain known cancer-associated (CAMs). Four more studies have since been published, all demonstrating existence CAMs in different subtypes endometriosis. While field still evolving, confirmation has raised many questions were previously overlooked. OBJECTIVE AND RATIONALE A comprehensive overview produced. In addition, with emerged understanding natural history endometriotic well normal apparently healthy tissues, this review attempts to address following questions: Why there such wild discrepancy mutation frequencies? does ectopic endometrium higher rate than eutopic endometrium? Would presence increase risk cancer bearers? do epithelial cells much frequencies their stromal counterpart? What clinical implications, if any, for Do these tell us anything about pathogenesis and/or pathophysiology endometriosis? SEARCH METHODS The PubMed database searched, from its inception September 2019, papers English using term ‘endometriosis CAM’, cancer-driver mutation’, ‘somatic mutations’, ‘fibrosis’, ‘fibrosis epigenetic’, ‘CAMs tumorigenesis’, tissues’, ‘oestrogen receptor fibrosis’, ‘oxidative stress ‘ARID1A ‘Kirsten rat sarcoma therapeutics’. All retrieved read and, relevant, incorporated into results. OUTCOMES Seven identified various sequencing methods retrieved, results somewhat different. Yet, apparent those microdissection techniques accurate found CAMs, echoing recent discoveries tissues also result replicative aging process. Hence lesions, irrespective subtype, left intact, would generate part aging, oxidative perhaps other factors yet be some rare cases, develop cancer. published data are unable paint clear picture on However, turnover counterpart due cyclic bleeding, component can formed by refresh influx mesenchymal through epithelial–mesenchymal transition, endothelial–mesenchymal mesothelial–mesenchymal transition processes recruitment bone-marrow-derived stem outflow smooth muscle metaplasia, counterpart. cellular components dependent co-evolving manner. Genes involved likely active players lesional fibrogenesis, hyperestrogenism drivers both fibrogenesis. Finally, harbouring conceivably refractory medical treatment, due, no small part, high fibrotic content reduced vascularity cellularity. WIDER IMPLICATIONS accumulating shed new light They suggest challenges management. distinct developmental trajectories stroma epithelium underscore importance microenvironment ever-changing identity. Mutational profiling women ages reproductive needed order gain deeper pathogenesis. Moreover, one area conspicuously received scant attention epigenetic landscape ectopic, endometrium.

Язык: Английский

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SCLC–State of the Art and What Does the Future Have in Store?

Clinical Lung Cancer, Год журнала: 2016, Номер 17(5), С. 325 - 333

Опубликована: Июнь 11, 2016

Язык: Английский

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The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge

Journal of Breast Cancer, Год журнала: 2018, Номер 21(3), С. 233 - 233

Опубликована: Янв. 1, 2018

Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over years due to extensive molecular and clinical research; a large number of cases, targeted therapies provided better prognosis. However, one specific subtype remains elusive therapies-the triple-negative breast cancer. This immunohistochemically defined is resistant both endocrine therapies, leading its poor A field that great promise current research epigenetics. By studying epigenetic mechanisms underlying tumorigenesis-DNA methylation, histone modifications, noncoding RNAs-advances treatment, diagnosis, prevention are possible. review aims synthesize discoveries been made related

Язык: Английский

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