Recent Advances in Endocannabinoid System Targeting for Improved Specificity: Strategic Approaches to Targeted Drug Delivery

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(21), С. 13223 - 13223

Опубликована: Окт. 30, 2022

Opportunities for developing innovative and intelligent drug delivery technologies by targeting the endocannabinoid system are becoming more apparent. This review provides an overview of strategies to develop targeted using (ECS). Recent advances in showcase enhanced pharmaceutical therapy specificity while minimizing undesirable side effects overcoming formulation challenges associated with cannabinoids. identifies that may permit access full pharmacotherapeutic potential ECS. The design optimized nanocarriers target specific tissues can be improved understanding nature signaling pathways, distribution mammalian body, receptor structure, enzymatic degradation A closer look at ligand-receptor complexes, tone, tissue distribution, G-protein activity leads a better ECS toolkit therapeutics. signal transduction pathways examine modulation downstream effector proteins, desensitization, cascades, biased signaling. An in-depth overall view is achieved through homology modeling where mutagenesis ligand binding site allow sequence analysis formation libraries molecular docking dynamic simulations. Internalization routes exploring receptor-mediated endocytosis lipid rafts also considered explicit Furthermore, highlights nanotechnology surface modification aspects as possible future approach targeting.

Язык: Английский

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Cannabidiol treatment improves metabolic profile and decreases hypothalamic inflammation caused by maternal obesity

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Март 9, 2023

The implications of maternal overnutrition on offspring metabolic and neuroimmune development are well-known. Increasing evidence now suggests that obesity poor dietary habits during pregnancy lactation can increase the risk central peripheral dysregulation in offspring, but mechanisms not sufficiently established. Furthermore, despite many studies addressing preventive measures targeted at mother, very few propose practical approaches to treat damages when they already installed.Here we investigated potential cannabidiol (CBD) treatment attenuate effects induced by a cafeteria diet hypothalamic inflammation profile Wistar rats.We have observed range imbalances sex-dependant manner, with higher deposition visceral white adipose tissue, increased plasma fasting glucose lipopolysaccharides (LPS) levels both sexes, serum cholesterol triglycerides only occurred females, while insulin homeostatic model assessment index (HOMA-IR) was male offspring. We also found an overexpression pro-inflammatory cytokines tumor necrosis factor-alpha (TNFα), interleukin (IL) 6, 1β hypothalamus, trademark neuroinflammation. Interestingly, expression GFAP, marker for astrogliosis, reduced obese mothers, indicating adaptive mechanism utero Treatment 50 mg/kg CBD oil oral gavage able reduce tissue revert resistance males, LPS TNFα IL6 hypothalamus sexes.Together, these results indicate intricate interplay between counterparts pathogenicity therapeutic CBD. In this context, impairment internal circuitry caused neuroinflammation runs tandem disruptions important processes, which be attenuated ends.

Язык: Английский

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Cannabidiol and its application in the treatment of oral diseases: therapeutic potentials, routes of administration and prospects

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116271 - 116271

Опубликована: Май 24, 2024

Cannabidiol (CBD), one of the most important active ingredients in cannabis, has been reported to have some pharmacological effects such as antibacterial and analgesic effects, therapeutic potential treatment oral diseases cancer, gingivitis periodontal diseases. However, there is a lack relevant systematic research reviews. Therefore, based on etiology clinical symptoms several common diseases, this paper focuses CBD pulp mucosal cancer temporomandibular joint The distribution function its receptors cavity are also summarized. In order provide reference for future further application CBD, we summarize possible routes administration corresponding characteristics. Finally, challenges faced while applying clinically solutions discussed, look future.

Язык: Английский

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Challenges of Cannabinoid Delivery: How Can Nanomedicine Help?

Nanomedicine, Год журнала: 2020, Номер 15(21), С. 2023 - 2028

Опубликована: Июнь 26, 2020

Язык: Английский

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The impact of cannabinoid type 2 receptors (CB2Rs) in neuroprotection against neurological disorders

Acta Pharmacologica Sinica, Год журнала: 2020, Номер 41(12), С. 1507 - 1518

Опубликована: Окт. 6, 2020

Язык: Английский

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