The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Март 18, 2022

Selenium-enriched mung bean (Se-MB) is a combination of (MB) and selenium (Se), which have variety potential biological activities. However, little known about the skincare activity Se-MB. The chemical composition Se-MB fermentation broth (Se-MBFB) was analyzed to investigate whitening, moisturizing, anti-aging activities Se-MBFB. tyrosinase inhibition, anti-melanogenic in melanocytes (B16F10 cells), moisturizing effect human dermal fibroblasts (HDFs) were analyzed. Besides, free radical scavenging Se-MBFB assessed vitro . To verify vivo effects practical applications Se-MBFB, clinical trial conducted on participants: 31 Chinese women aged 25–60 years, with no pigmentation disorder, illness, history hypersensitivity reaction, use product face. participants used an masque for 15-20 min after cleaning measurement points Week 0, 2, 4 (W0, W2, W4) using masque, target sites cheek canthus. following parameters recorded at each visit: melanin index, skin color, cuticle moisture content, transepidermal water loss, crow's feet. results demonstrated that rich polyphenols, peptides, γ-aminobutyric acid (GABA), displayed significant inhibiting activities, decreased synthesis melanin, upregulated aquaporin-3 (AQP3) expression. test mask showed weeks facemask, faces became whiter reduced wrinkles increased content. possessed excellent antioxidant efficacy, could lay scientific foundation utilization development products its related industrial cosmetics products.

Язык: Английский

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Valorization of Polysaccharides From Benincasa hispida: Physicochemical, Moisturizing, and Antioxidant Skincare Properties

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Июнь 17, 2022

Benincasa hispida Cogn. ( B. ) is a popular vegetable in China, and studies have been reported on polysaccharides (BPS) preparation. However, few its physicochemical skincare properties. In this study, we analyzed the properties of BPS, free radical scavenging capability, moisturizing antioxidant activities vitro vivo , respectively. Our results show that BPS was an inhomogeneous acidic polysaccharide could scavenge variety radicals. Also, had good capability both . Specifically, alter some key enzyme pro-inflammatory factor levels via activating NRF2/HO-1 pathway, thereby preventing H 2 O -induced reactive oxygen species (ROS) production apoptosis HDF-1 cells. suggest exhibited favorable anti-aging might be attractive candidate for development products.

Язык: Английский

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Feasibility of repairing skin defects by VEGF₁₆₅ gene‐modified iPS‐HFSCs seeded on a 3D printed scaffold containing astragalus polysaccharide

Journal of Cellular and Molecular Medicine, Год журнала: 2023, Номер 27(15), С. 2136 - 2149

Опубликована: Июнь 1, 2023

Abstract The preparation of biodegradable scaffolds loaded with cells and cytokine is a feature tissue‐engineered skin. IPSCs‐based skin treatment for wound repair worth exploring. Healthy human fibroblasts were collected reprogrammed into iPSCs. After gene modification induction, CK19 + /Integrinβ1 /CD200 VEGF 165 gene‐modified iPS‐HFSCs GFP obtained identified by combination immunofluorescence RT‐qPCR. Astragalus polysaccharide‐containing 3D printed degradable prepared co‐cultured , the biocompatibility spatial structure was analysed cell counting kit‐8 (CCK8) assay scanning electron microscopy. Finally, transplanted onto dorsal trauma nude mice, effect on regenerative total defects evaluated histology, immunohistochemistry, immunofluorescence, RT‐qPCR, in vivo three‐dimensional reconstruction under two‐photon close to morphology phenotype human‐derived hair follicle stem cells, obtained. surface scaffold containing 200 μg/mL astragalus polysaccharide enriched honeycomb‐like meshwork, which more conducive proliferation resulting cells. transplantation, combined assays showed that it promoted early vascularization, collagen regeneration accelerated repair. compounded can directly indirectly participate vascular, collagen, skin, achieving complete structural functional

Язык: Английский

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A sustainable and self-healable silk fibroin nanocomposite with antibacterial and drug eluting properties for 3D printed wound dressings

Journal of Materials Chemistry B, Год журнала: 2023, Номер 12(3), С. 784 - 799

Опубликована: Дек. 15, 2023

An injectable and printable nanocomposite hydrogel with multiple functionalities is reported, providing a platform for bioengineering of nature-derived materials advanced wound care.

Язык: Английский

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Interorgan Metabolism of Amino Acids in Human Health and Disease

Advances in experimental medicine and biology, Год журнала: 2021, Номер unknown, С. 129 - 149

Опубликована: Янв. 1, 2021

Язык: Английский

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