Did doubly uniparental inheritance (DUI) of mtDNA originate as a cytoplasmic male sterility (CMS) system?
BioEssays,
Год журнала:
2022,
Номер
44(4)
Опубликована: Фев. 16, 2022
Abstract
Animal
and
plant
species
exhibit
an
astonishing
diversity
of
sexual
systems,
including
environmental
genetic
determinants
sex,
with
the
latter
material
in
mitochondrial
genome.
In
several
hermaphroditic
plants
for
example,
sex
is
determined
by
interaction
between
cytoplasmic
male
sterility
(CMS)
genes
nuclear
restorer
genes.
Specifically,
CMS
involves
aberrant
that
prevent
pollen
development
specific
restore
it,
leading
to
a
mixture
female
(male‐sterile)
individuals
population
(gynodioecy).
Such
mitochondrial‐nuclear
determination
system
thought
be
rare
outside
plants.
Here,
we
present
one
possible
case
animals.
We
hypothesize
only
exception
strict
maternal
mtDNA
inheritance
animals,
doubly
uniparental
(DUI)
bivalves,
might
have
originated
as
sex‐determination
system.
document
explore
similarities
exist
DUI
CMS,
propose
various
ways
test
our
hypothesis.
Язык: Английский
Investigating the role of mitochondrial membrane potential in paternal inheritance of mitochondria
Biological Journal of the Linnean Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 9, 2024
Abstract
The
process
of
oxidative
phosphorylation
(OXPHOS)
in
mitochondria
depends
on
an
electrochemical
gradient
known
as
the
mitochondrial
membrane
potential
(Δψm).
Reflecting
high
functionality,
elevated
Δψm
usually
depicts
healthy
and
contributes
to
organelle
selection.
This
study
investigates
whether
properties
linked
with
bioenergetics,
such
Δψm,
play
a
role
paternal
inheritance
mitochondria.
More
specifically,
looks
at
how
sperm
responds
egg
chemoattractants
bivalves
characterized
by
distinct
patterns:
strict
maternal
(SMI)
doubly
uniparental
(DUI),
latter
displaying
sex-specific
transmission
DNA.
Sperm
was
examined
four
bivalve
species:
blue
mussel
(Mytilus
edulis)
Manila
clam
(Ruditapes
philippinarum)
plus
hard
(Mercenaria
mercenaria)
soft-shell
(Mya
arenaria)
(SMI).
In
absence
chemoattractants,
did
not
vary
between
two
groups.
However,
there
trend
increase
following
detection
only
bearing
paternally
derived
(DUI).
suggests,
along
bioenergetic
changes,
that
modulation
might
be
specific
property
least
some
DUI
species,
possibly
implicated
their
unique
ability
transmit
fashion.
Язык: Английский
High heteroplasmy is associated with low mitochondrial copy number and selection against non-synonymous mutations in the snail Cepaea nemoralis
BMC Genomics,
Год журнала:
2024,
Номер
25(1)
Опубликована: Июнь 13, 2024
Molluscan
mitochondrial
genomes
are
unusual
because
they
show
wide
variation
in
size,
radical
genome
rearrangements
and
frequently
high
(>
10%)
within
species.
As
progress
understanding
this
has
been
limited,
we
used
whole
sequencing
of
a
six-generation
matriline
the
terrestrial
snail
Cepaea
nemoralis,
as
well
sequences
from
wild-collected
C.
sister
species
hortensis,
multiple
other
to
explore
origins
DNA
(mtDNA)
variation.
The
main
finding
is
that
rate
SNP
heteroplasmy
somatic
tissue
was
negatively
correlated
with
mtDNA
copy
number
both
In
individuals
under
ten
copies
per
nuclear
genome,
more
than
10%
all
positions
were
heteroplasmic,
evidence
for
transmission
through
germline.
Further
analyses
showed
purifying
selection
acting
on
non-synonymous
mutations,
even
at
low
frequency
rare
allele,
especially
cytochrome
oxidase
subunit
1
b.
some
nemoralis
contained
length
heteroplasmy,
including
up
12
direct
repeat
tRNA-Val,
24
another
snail,
Candidula
rugosiuscula,
repeats
tRNA-Thr
hortensis.
These
likely
arise
due
error
prone
replication
but
not
nemoralis.
Overall,
findings
provide
key
insights
into
mechanisms
replication,
mutation
evolution
molluscan
mtDNA,
so
will
inform
wider
studies
biology
across
animal
phyla.
Язык: Английский
Relaxed selection on male mitochondrial genes in DUI bivalves eases the need for mitonuclear coevolution
Journal of Evolutionary Biology,
Год журнала:
2021,
Номер
34(11), С. 1722 - 1736
Опубликована: Сен. 17, 2021
Mitonuclear
coevolution
is
an
important
prerequisite
for
efficient
energy
production
in
eukaryotes.
However,
many
bivalve
taxa
experience
doubly
uniparental
inheritance
(DUI)
and
have
sex-specific
mitochondrial
(mt)
genomes,
providing
a
challenge
mitonuclear
coevolution.
We
examined
possible
mechanisms
to
reconcile
with
DUI.
No
nuclear-encoded,
OXPHOS
paralogs
were
found
the
DUI
clam
Ruditapes
philippinarum,
refuting
paralogy
as
solution
this
species.
It
also
unlikely
that
mt
changes
causing
disruption
of
nuclear
interactions
are
strongly
selected
against
because
mt-residues
or
those
under
positive
selection
M
genes
not
depleted
contacting
nuclear-encoded
residues.
genomes
showed
consistently
higher
dN
/dS
ratios
compared
putatively
ancestral
F
all
across
Further
analyses
indicated
was
due
relaxed,
on
vs.
genes.
Similarly,
relaxed
genome
species
strict
maternal
inheritance.
Coupled
recent
physiological
molecular
evolution
studies,
we
suggest
function
limits
need
maintain
genomes.
discuss
our
findings
regard
origin
Язык: Английский
New Perspectives on the Evolution of Within-Individual Genome Variation and Germline/Soma Distinction
Genome Biology and Evolution,
Год журнала:
2021,
Номер
13(6)
Опубликована: Май 7, 2021
Abstract
Genomes
can
vary
significantly
even
within
the
same
individual.
The
underlying
mechanisms
are
manifold,
ranging
from
somatic
mutation
and
recombination,
development-associated
ploidy
changes
genetic
bottlenecks,
over
to
programmed
DNA
elimination
during
germline/soma
differentiation.
In
this
perspective
piece,
we
briefly
review
recent
developments
in
study
of
within-individual
genome
variation
eukaryotes
prokaryotes.
We
highlight
a
Society
for
Molecular
Biology
Evolution
2020
virtual
symposium
entitled
“Within-individual
distinction”
present
Special
Section
name
Genome
Evolution,
together
fostering
cross-taxon
synergies
field
identify
tackle
key
open
questions
understanding
variation.
Язык: Английский
Mitochondrion-to-nucleus communication mediated by RNA export: a survey of potential mechanisms and players across eukaryotes
Biology Letters,
Год журнала:
2024,
Номер
20(7)
Опубликована: Июль 1, 2024
The
nucleus
interacts
with
the
other
organelles
to
perform
essential
functions
of
eukaryotic
cell.
Mitochondria
have
their
own
genome
and
communicate
back
in
what
is
known
as
mitochondrial
retrograde
response.
Information
transferred
many
ways,
leading
wide-ranging
changes
nuclear
gene
expression
culminating
metabolic,
regulatory
or
stress-related
pathways.
RNAs
are
emerging
molecules
involved
this
signalling.
encode
precise
information
highly
target-specific
signalling,
through
a
wide
range
processes
RNA
interference.
RNA-mediated
response
requires
these
exit
mitochondrion,
process
that
still
mostly
unknown.
We
suggest
proteins/complexes
translocases
inner
membrane,
polynucleotide
phosphorylase,
permeability
transition
pore,
subunits
oxidative
phosphorylation
complexes
may
be
responsible
for
export.
Язык: Английский
The effect of mitochondrial recombination on fertilization success in blue mussels
The Science of The Total Environment,
Год журнала:
2023,
Номер
913, С. 169491 - 169491
Опубликована: Дек. 26, 2023
The
presence
of
doubly
uniparental
inheritance
(DUI)
in
bivalves
represents
a
unique
mode
mitochondrial
transmission,
whereby
paternal
(male-transmitted
M-type)
and
maternal
(female-transmitted
F-type)
haplotypes
are
transmitted
to
offspring
separately.
Male
embryos
retain
both
haplotypes,
but
the
M-type
is
selectively
removed
from
females.
Due
heteroplasmy
males,
mtDNA
can
recombine
resulting
'masculinized'
haplotype
referred
as
Mf-type.
While
recombination
usually
rare,
it
has
been
recorded
multiple
mussel
species
across
Northern
Hemisphere.
Given
that
mitochondria
powerhouse
cell,
different
may
have
selective
advantages
under
diverse
environmental
conditions.
This
be
particularly
important
for
sperm
fitness
fertilization
success.
In
this
study
we
aimed
i)
determine
presence,
prevalence
Mf-type
Australian
blue
mussels
(Mytilus
sp.)
ii)
investigate
effect
Mf-mtDNA
on
performance
(a
correlate).
We
found
high
recombined
(≈35
%)
located
within
control
region
genome,
which
occurred
only
specimens
contained
Southern
Hemisphere
mtDNA.
two
female
mitotypes
were
identified
studied
mussels,
one
likely
originating
Hemisphere,
other
either
representing
endemic
M.
planulatus
or
introduced
genotypes
Despite
having
events
present
third
population,
analysis
indicated
no
difference
success
related
mitotype.
Язык: Английский
A proposed method for analyzing molecular signatures to detect hermaphroditism in freshwater mussels: a case study using the eastern floater (Pyganodon cataracta)
Canadian Journal of Zoology,
Год журнала:
2021,
Номер
99(6), С. 450 - 458
Опубликована: Март 4, 2021
Many
freshwater
mussels
(order
Unionida)
have
an
unusual
system
of
doubly
uniparental
inheritance
(DUI)
mitochondrial
(mt)
DNA.
In
species
with
DUI,
males
possess
a
female-transmitted
(F-type)
mt
genome
and
male-transmitted
(M-type)
genome.
These
genomes
contain
non-canonical
open
reading
frame
(orf)
genes,
referred
to
as
f-orf
m-orf,
present
in
F
M
genomes,
respectively.
genes
been
implicated
sexual
development
Unionida.
When
gonochoric
become
hermaphroditic,
which
has
happened
several
times
Unionida,
they
lose
their
M-type
evolve
dramatically.
Resulting
F-ORF
proteins
are
highly
divergent
terms
primary
nucleotide
sequence,
inferred
amino
acids,
hydrophobic
properties;
these
(and
proteins)
hermaphroditic
orfs
or
h-orfs
H-ORFs).
We
investigated
patterns
hydrophobicity
divergence
for
H-ORF
hermaphrodites
versus
closely
related
against
cytochrome
c
oxidase
subunit
1
(cox1)
divergences.
This
approach
was
used
assess
whether
cryptic
can
be
detected.
Although
we
did
not
detect
evidence
the
recent
transition
any
populations
eastern
floaters
(Pyganodon
cataracta
(Say,
1817))
hermaphroditism,
our
analyses
demonstrate
that
molecular
signatures
mtDNA
hermaphroditism
mussels.
Язык: Английский
Investigating the role of mitochondrial membrane potential in paternal inheritance of mitochondria
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 2, 2023
Abstract
The
process
of
oxidative
phosphorylation
(OXPHOS)
in
mitochondria
depends
on
an
electrochemical
gradient
known
as
the
mitochondrial
membrane
potential
(Δ
ψ
m).
Reflecting
high
functionality,
elevated
Δ
m
usually
depicts
healthy
and
contribute
to
organelle
selection.
This
study
investigates
whether
properties
linked
with
bioenergetics,
such
m,
may
play
a
role
paternal
inheritance
mitochondria.
More
specifically,
how
sperm
responds
egg
chemoattractants
bivalves
characterized
by
distinct
patterns:
strict
maternal
(SMI)
doubly
uniparental
(DUI),
latter
displaying
sex-specific
transmission
DNA
(mtDNA).
Sperm
was
examined
four
bivalve
species:
Mytilus
edulis
Ruditapes
philippinarum
plus
Mercenaria
mercenaria
Mya
arenaria
(SMI).
In
absence
oocytes,
did
not
vary
between
two
groups.
However,
we
revealed
increase
following
detection
only
bearing
paternally-derived
(DUI).
suggests,
along
bioenergetic
changes,
that
modulation
might
be
specific
property
DUI
mitochondria,
possibly
implicated
their
unique
ability
sex-specifically
transmitted.
Язык: Английский