A review on pectin-based nanostructures for drug and gene delivery systems

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140932 - 140932

Опубликована: Фев. 11, 2025

Язык: Английский

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Nanoparticle-Mediated Embryotoxicity: Mechanisms of Chemical Toxicity and Implications for Biological Development

Chemical Research in Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.

Язык: Английский

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Catalytic Activity of Platinum and Palladium Nanoparticles PAPLAL in the Decomposition of Hydrogen Peroxide H2O2

Bulletin of the Russian Academy of Sciences Physics, Год журнала: 2024, Номер 88(S4), С. S630 - S632

Опубликована: Дек. 1, 2024

Язык: Английский

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Multifaceted role of phytoconstituents based nano drug delivery systems in combating TNBC: A paradigm shift from chemical to natural

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(12), С. 9207 - 9226

Опубликована: Июль 2, 2024

Язык: Английский

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