Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Год журнала:
2022,
Номер
13(1)
Опубликована: Сен. 20, 2022
Emerging
evidence
suggests
an
important
role
of
vitamin
D
in
the
establishment
and
maintenance
pregnancy,
regulation
foetal
growth
across
mammalian
species.
However,
temporal
changes
maternal
status
throughout
gestation
pig
relationship
between
litter
characteristics
interest
remain
poorly
understood
under-investigated.
The
abundance
25(OH)D
plasma
was
quantified
by
HPLC-MS/MS
at
gestational
days
(GD)
18,
30,
45,
60
90
(n
=
5-11
gilts/GD).
Maternal
concentrations
significantly
increased
GD18
GD30
(P
<
0.05).
metabolite
including
gilt
weight,
ovulation
rate,
mean
number
live
foetuses,
percentage
prenatal
survival,
sex
ratio
assessed.
0.059)
tended
to
be
positively
associated
with
survival
on
GD60.
On
GD90,
0.05)
were
inversely
weight.
male
foetuses
GD90
This
study
has
provided
novel
insights
into
economically
litter.
Improving
understanding
developmental
timepoints
relation
is
essential
improve
reproductive
success
livestock
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(14), С. 7795 - 7795
Опубликована: Июль 14, 2022
Minerals
are
required
for
the
establishment
and
maintenance
of
pregnancy
regulation
fetal
growth
in
mammals.
Lentiviral-mediated
RNA
interference
(RNAi)
chorionic
somatomammotropin
hormone
(CSH)
results
both
an
intrauterine
restriction
(IUGR)
a
non-IUGR
phenotype
sheep.
This
study
determined
effects
CSH
RNAi
on
concentration
uptake
calcium,
phosphate,
vitamin
D,
expression
candidate
mRNAs
known
to
mediate
mineral
signaling
caruncles
(maternal
component
placentome)
cotyledons
(fetal
gestational
day
132.
Non-IUGR
pregnancies
had
lower
umbilical
vein–umbilical
artery
calcium
gradient
(p
<
0.05)
less
cotyledonary
phosphate
compared
Control
pregnancies.
IUGR
0.05),
uterine
arterial
venous
concentrations
25(OH)D
trends
=
0.059)
Furthermore,
decreased
(vitamin
D
metabolite;
p
0.055),
caruncular
SLC20A2
(sodium-dependent
transporter;
mRNA,
KL
(klotho;
0.01),
FGFR1
(fibroblast
factor
receptor
1;
FGFR2
TRPV6
(transient
potential
vanilloid
member
6;
has
provided
novel
insights
into
regulatory
role
utilization
late
gestation.
Obstetrics & Gynecology Science,
Год журнала:
2023,
Номер
66(5), С. 395 - 406
Опубликована: Авг. 1, 2023
Objective
Hypovitaminosis
D3
is
a
significant
concern
among
pregnant
women
and
their
newborns
because
vitamin
(Vit-D3)
plays
crucial
role
in
embryonic
growth,
development,
health.
This
study
aimed
to
evaluate
the
Vit-D3
status
of
group
Iranian
its
association
with
newborn
levels,
medical
clinical
indices
after
delivery.Methods
A
total
206
were
assessed
for
levels
correlation
gestational
age.
Mean±standard
deviation
(SD)
or
orders
(non-parametric
tests)
variables
compared,
estimations
performed
elucidate
any
differences
associations
between
groups,
confidence
interval
at
least
0.95.Results
The
mean±SD
mothers’
age
29.65±6.18
years
35.59±1.6
weeks,
respectively.
Neonatal
associated
maternal
Using
30
ng/mL
cutoff
point
serum
83.5%
84.7%
had
hypovitaminosis
D3.
average
mothers
delivery
time
23.5±8.07
20.76±9.14
ng/mL,
Newborn
positively
correlated
(R=0.744;
<i>P</i><0.001)
(R=0.161;
<i>P</i>=0.022).
In
newborns,
head
circumference
was
inversely
bilirubin
level
(R=-0.302;
but
directly
weight
(R=0.640;
<i>P</i><0.001).Conclusion
remains
challenge
women.
Maternal
provide
newborn’s
needs,
particularly
late
stages
pregnancy.
Therefore,
supplementation
regular
monitoring
are
essential
newborns.
Biology of Reproduction,
Год журнала:
2023,
Номер
109(6), С. 954 - 964
Опубликована: Сен. 7, 2023
Abstract
Tissue-nonspecific
alkaline
phosphatase
(TNSALP;
encoded
by
ALPL
gene)
has
a
critical
role
in
the
regulation
of
phosphate
homeostasis
postnatally.
However,
utero-placental
expression
TNSALP
and
transport
pregnancy
is
poorly
understood.
Estrous
cycles
ewes
were
synchronized,
euthanized
hysterectomized
on
Days
1,
9,
or
14
estrous
cycle
bred
to
fertile
rams
12,
17,
30,
50,
70,
90,
110,
125
pregnancy.
The
mRNA,
immunolocalization
protein,
quantification
localization
enzymatic
activity
was
performed
ovine
endometria
placentomes.
Day
did
not
alter
mRNA
TNSALP.
protein
localized
uterine
epithelial
stromal
cells,
blood
vessels,
myometrium,
caruncular,
cotyledonary
stroma.
epithelia,
caruncular
stroma
(from
70
gestation),
apical
surface
chorionic
epithelia
50
gestation).
during
early
Endometrial
downregulated
17
30
gestation
(P
<
0.05).
Expression
decreased
late
placentomes
peaked
90
gestation.
Collectively,
these
results
suggest
potential
at
maternal–conceptus
interface
ruminants.
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 3, 2024
Tissue
non-specific
alkaline
phosphatase
(TNSALP;
encoded
by
the
ALPL
gene)
has
a
critical
role
in
postnatal
regulation
of
phosphate
homeostasis,
yet
how
TNSALP
activity
and
expression
are
regulated
during
pregnancy
remain
largely
unknown.
This
study
tested
hypothesis
that
progesterone
(P4)
and/or
interferon
tau
(IFNT)
regulate
sheep.
In
Exp.
1,
ewes
were
bred
received
daily
intramuscular
injections
either
corn
oil
vehicle
(CO)
or
25
mg
CO
for
first
8
days
hysterectomized
on
Day
9,
12,
125
gestation.
2,
fitted
with
intrauterine
catheters
7
estrous
cycle
50
P4
75
receptor
antagonist
(RU486)
from
Days
to
15,
twice
control
proteins
(CX)
IFNT
(25
µg/uterine
horn/d)
11
15
(treatment
groups:
+
CX;
IFNT;
RU486
IFNT)
16.
endometria
administered
had
greater
mRNA
than
12.
appeared
epithelia,
stratum
compactum
stroma,
endothelium
blood
vessels
endometrium
myometrium
On
125,
localized
uterine
epithelial
endothelial
cells,
independent
treatment.
placentomes
treated
was
detected
cells
caruncular
tissue
but
not
ewes.
endometrial
homogenates
CX
lower
those
Immunoreactive
protein
mid-
deep-glandular
epithelia
as
compared
other
treatment
groups.
Enzymatic
apical
surface
deep
glandular
These
results
suggest
P4,
IFNT,
regulates
utero-placental
tissues
potential
contribute
availability
is
conceptus
development
pregnancy.
Journal of Clinical Biochemistry and Nutrition,
Год журнала:
2024,
Номер
76(2), С. 164 - 178
Опубликована: Окт. 28, 2024
This
case-control
study
of
124
early-pregnant
women
found
that
daily
supplementation
with
400
IU
vitamin
D3
significantly
increased
serum
1,25-(OH)D3
levels
and
was
associated
a
lower
incidence
threatened
miscarriage.
The
suggests
could
reduce
the
risk
early
miscarriage
improve
pregnancy
outcomes
by
modulating
immune
responses
hormonal
stability.
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Год журнала:
2022,
Номер
13(1)
Опубликована: Сен. 20, 2022
Emerging
evidence
suggests
an
important
role
of
vitamin
D
in
the
establishment
and
maintenance
pregnancy,
regulation
foetal
growth
across
mammalian
species.
However,
temporal
changes
maternal
status
throughout
gestation
pig
relationship
between
litter
characteristics
interest
remain
poorly
understood
under-investigated.
The
abundance
25(OH)D
plasma
was
quantified
by
HPLC-MS/MS
at
gestational
days
(GD)
18,
30,
45,
60
90
(n
=
5-11
gilts/GD).
Maternal
concentrations
significantly
increased
GD18
GD30
(P
<
0.05).
metabolite
including
gilt
weight,
ovulation
rate,
mean
number
live
foetuses,
percentage
prenatal
survival,
sex
ratio
assessed.
0.059)
tended
to
be
positively
associated
with
survival
on
GD60.
On
GD90,
0.05)
were
inversely
weight.
male
foetuses
GD90
This
study
has
provided
novel
insights
into
economically
litter.
Improving
understanding
developmental
timepoints
relation
is
essential
improve
reproductive
success
livestock
