Handheld Nir Spectroscopy for Species Discrimination of Closely Related Plant Families: Case Study of Ancistrocladus Abbreviatus, Triphyophyllum Peltatum, and Nepenthes Alata

Опубликована: Янв. 1, 2025

Язык: Английский

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Korupensamine A, but not its atropisomer, korupensamine B, inhibits SARS-CoV-2 in vitro by targeting its main protease (Mpro)

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 251, С. 115226 - 115226

Опубликована: Фев. 28, 2023

Язык: Английский

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Cytotoxicity of dioncophylline A and related naphthylisoquinolines in leukemia cells, mediated by NF-κB inhibition, angiogenesis suppression, G2/M cell cycle arrest, and autophagy induction

Phytomedicine, Год журнала: 2023, Номер 126, С. 155267 - 155267

Опубликована: Дек. 8, 2023

Inhibition of NF-κB activity represents a strategy to treat acute myeloid leukemia, one the most lethal leukemia types. Naphthylisoquinolines (NIQs) are cytotoxic alkaloids from lianas families Ancistrocladaceae and Dioncophyllaceae, which indigenous tropical rainforests.

Язык: Английский

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Distribution of Acetogenic Naphthoquinones in Droseraceae and Their Chemotaxonomic Utility

Biology, Год журнала: 2024, Номер 13(2), С. 97 - 97

Опубликована: Фев. 3, 2024

Chemotaxonomy is the link between state of art in analytical chemistry and systematic classification phylogenetic analysis biota. Although characteristic secondary metabolites from diverse biotic sources have been used pharmacology biological systematics since dawn mankind, only comparatively recently established reproducible methods allowed precise identification distinction structurally similar compounds. Reliable, rapid screening like TLC (Thin Layer Chromatography) can be to investigate sufficiently large numbers samples for chemotaxonomic purposes. Using distribution patterns mutually exclusive naphthoquinones, it demonstrated this review how a simple set chemical data representative sample closely related species sundew family (Droseraceae, Nepenthales) provides taxonomically phylogenetically informative signal within investigated group beyond.

Язык: Английский

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Naphthylisoquinoline alkaloids: novel agents against the causative pathogens of eumycetoma and actinomycetoma— en route to broad-spectrum antimycetomal drugs

Antimicrobial Agents and Chemotherapy, Год журнала: 2024, Номер 68(5)

Опубликована: Апрель 11, 2024

Mycetoma is a devastating neglected tropical infection of the subcutaneous tissues. It caused by fungal and bacterial pathogens recognized as eumycetoma actinomycetoma, respectively. treatment involves diagnosing causative microorganism prerequisite to prescribing proper medication. Current therapy agents, such

Язык: Английский

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Structural variety and pharmacological potential of naphthylisoquinoline alkaloids

˜The œAlkaloids. Chemistry and biology/˜The œalkaloids. Chemistry and biology, Год журнала: 2024, Номер unknown, С. 1 - 410

Опубликована: Янв. 1, 2024

Язык: Английский

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Ancistrobrevinium A, the first N -methylated, cationic naphthylisoquinoline alkaloid, from the tropical liana Ancistrocladus abbreviatus (Ancistrocladaceae)

Natural Product Research, Год журнала: 2023, Номер 38(15), С. 2614 - 2618

Опубликована: Март 29, 2023

Ancistrobrevinium A (1) is the first N-methylated and non-hydrogenated, thus cationic naphthylisoquinoline alkaloid. It was discovered in root bark extract of phytochemically productive West African liana Ancistrocladus abbreviatus (Ancistrocladaceae). Its constitution elucidated by HR-ESI-MS 1D 2D NMR. Due to steric hindrance proximity linkage between naphthalene isoquinoline parts, biaryl axis rotationally hindered. constitutes a stable element chirality – only one new alkaloid since, different from most other alkaloids, it has no stereogenic centers. The axial configuration 1 assigned electronic circular dichroism (ECD) investigations, which gave positive couplet, indicating 'positive chirality', here corresponding P-configuration. showed weak cytotoxic activity against A549 lung cancer cells (IC50 = 50.6 μM).

Язык: Английский

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Dioncophyllidine E: The first configurationally semi-stable, 7,3′-coupled naphthyldihydroisoquinoline alkaloid, from Ancistrocladus abbreviatus, with antiausterity activity against PANC-1 human pancreatic cancer cells

Bioorganic & Medicinal Chemistry Letters, Год журнала: 2023, Номер 86, С. 129234 - 129234

Опубликована: Март 10, 2023

Язык: Английский

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Jozimine A2, a Dimeric Naphthylisoquinoline (NIQ) Alkaloid, Shows In Vitro Cytotoxic Effects against Leukemia Cells through NF-κB Inhibition

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3087 - 3087

Опубликована: Март 7, 2024

Naphthylisoquinoline (NIQ) alkaloids are rising as a promising class of secondary metabolites with pharmaceutical potential. NF-κB has already been recognized significant modulator cancer proliferation and drug resistance. We have previously reported the mechanisms behind cytotoxic effect dioncophylline A, an NIQ monomer, in leukemia cells. In current study, we investigated jozimine A2, dimer, on cells comparison to second, structurally unsymmetric michellamine B. To this end, molecular docking was applied predict binding affinity dimers towards NF-κB, which then validated through microscale thermophoresis. Next, cytotoxicity assays were performed CCRF-CEM multidrug-resistant CEM/ADR5000 following treatment. Transcriptome analysis uncovered networks affected by A2 identified cell cycle one major processes. Cell death modes evaluated flow cytometry, while angiogenesis measured endothelial tube formation assay human umbilical vein (HUVECs). The results indicated that bound inhibited its activity prevented translocation nucleus. addition, induced apoptosis angiogenesis. Our study describes explains interactions signaling pathway anticancer activity.

Язык: Английский

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Jozibrevine D from Ancistrocladus ileboensis, the fifth alkaloid in a series of six possible atropo-diastereomeric naphthylisoquinoline dimers, showing antiparasitic and antileukemic activities

Bioorganic & Medicinal Chemistry Letters, Год журнала: 2023, Номер 86, С. 129258 - 129258

Опубликована: Март 25, 2023

Язык: Английский

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