Characteristics of the Digestive Tract of Dogs and Cats
Advances in experimental medicine and biology,
Год журнала:
2024,
Номер
unknown, С. 15 - 38
Опубликована: Янв. 1, 2024
Язык: Английский
Recent Advances in the Nutrition and Metabolism of Dogs and Cats
Advances in experimental medicine and biology,
Год журнала:
2024,
Номер
unknown, С. 1 - 14
Опубликована: Янв. 1, 2024
Язык: Английский
Golden Rice Project and Its Impact on Global Nutritional Security
Опубликована: Фев. 27, 2025
Язык: Английский
Interaction of Asparagusic Acid, Asparaptines and Related Dithiolane Derivatives With Angiotensin‐Converting Enzyme‐2 (ACE‐2): A Molecular Docking Study
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2025,
Номер
39(4)
Опубликована: Март 24, 2025
ABSTRACT
A
variety
of
sulfur‐containing
small
molecules
can
be
found
in
the
spears
asparagus
(
Asparagus
Officinalis
L.)
including
compounds
derived
from
asparagusic
acid
such
as
amino
derivatives
asparaptines
A,
B,
and
C.
The
previous
characterization
asparaptine
an
inhibitor
angiotensin‐converting
enzyme
(ACE)
prompted
us
to
compare
binding
three
ACE2
using
molecular
modeling.
lysine
conjugate
B
was
bind
better
than
arginine
(asparaptine
A)
histidine
C)
conjugates.
stability
ACE2‐asparaptine
complexes
only
a
little
inferior
that
observed
with
reference
MLN‐4760.
On
this
basis,
20
additional
bearing
thiol
group
or
dithiolane
motif
were
evaluated
potential
binders
same
docking
methodology.
Three
emerged
robust
binders:
natural
products
isovalthine
N‐acetyl‐felinine,
drug
candidate
CMX‐2043.
empirical
energy
interaction
(ΔE)
N‐acetyl‐felinine
comparable
measured
higher
metabolite
isovalthine.
Remarkably,
CMX‐2043
revealed
high
capacity
form
stable
ACE2,
superior
Both
l
‐Glu‐
‐Ala
dipeptide
α‐lipoic
moiety
are
implicated
protein
interaction.
Our
observations
pave
way
design
novel
ligands
equipped
motif.
Язык: Английский
Comparative analysis of PFASs concentrations in fur, muscle, and liver of wild roe deer as biomonitoring matrices
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Дек. 23, 2024
Background
Recently,
environmental
pollution
has
become
a
significant
concern
for
human,
animal,
and
health,
fitting
within
the
“One
Health”
framework.
Among
various
contaminants,
per-
polyfluoroalkyl
substances
(PFASs)
have
gathered
substantial
attention
due
to
their
persistence,
bioaccumulation,
adverse
health
effects.
This
study
aimed
compare
levels
of
12
PFASs
in
fur,
liver,
muscle
wild
roe
deer
evaluate
feasibility
using
fur
as
non-invasive
biomonitoring
matrix.
Methods
A
total
20
male
female
aged
between
24
months
were
randomly
sampled
from
hunting
area
Northern
Italy.
Samples
muscle,
liver
collected
post-mortem,
PFAS
concentrations
measured
validated
UHPLC-HRMS
method.
Results
discussion
The
results
indicated
differences
among
three
matrices.
Fur,
although
easier
sample
store,
showed
highly
variable
levels,
with
different
detection
frequencies
compared
liver.
such
PFHxA
more
frequently
detected
than
while
compounds
PFBA,
PFPeA,
PFHpA,
PFDA,
PFHxS,
6-2
FTS,
8-2
FTS
less
fur.
In
conclusion,
presents
many
practical
advantages
biomonitoring,
sampling
stability,
its
use
is
complicated
by
varying
concentration
levels.
These
aspects,
together
single
technique,
can
be
considered
limitation
study.
Notably,
PFOA,
PFNA,
PFOS
partially
similar
across
matrices,
suggesting
potential
interest
further
research.
offers
new
perspectives
on
monitoring,
highlighting
need
extensive
research
understand
relationship
other
biological
Future
studies
should
focus
methodological
improvements
extraction
quantification
techniques
enhance
reliability
tool.
Язык: Английский
Three-dimensional reconstruction of gustatory papillae and its taste buds in short-hair cats (Felis Catus domestica, felidae, Carnivora)
Veterinary Research Communications,
Год журнала:
2025,
Номер
49(4)
Опубликована: Май 15, 2025
Previous
studies
on
the
cat's
tongue
focused
anatomy
of
and
lingual
papillae
micromorphology.
According
to
new
challenges
in
gustatory
papillae,
we
adopted
a
modern
computer-aided
method
3D
reconstruction
from
serial
2D
cross-sections
description
taste
bud
system.
The
study
short-hair
cats
aimed
for
first
time
carnivores
analyze
fungiform
(Fu
papillae)
vallate
(Vp
with
spatial
visualization
connective
tissue
cores
(CTCs)
arrangement
exact
number
buds
(Tbs).
Results
indicate
diversity
size
internal
microstructure
Fu
Vp
cats.
Four
types
CTCs
were
distinguished
papillae:
mushroom-like,
club-like,
columnar-like,
bud-like,
whereas
CTC
was
mushroom-like.
Tbs
either
evenly
distributed
or
grouped.
analyzed
particular
parts
revealed
differences
its
number.
estimated
total
up
circa
8265.
Our
analyses
highlight
functional
importance
different
regions:
apex
food
preselection,
lateral
surfaces
analyzing
chewed
food,
caudal
part
final
tasting
before
swallowing.
Comparing
our
results
previous
herbivores,
recommend
using
proposed
as
effective
tools
further
comparative
mammalian
structures.
Язык: Английский
Urinary and Fecal Excretion of 121 Environmental Chemicals in Pet Dogs and Cats: Significance of Feces in Biomonitoring of Exposures
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(32), С. 14169 - 14179
Опубликована: Июль 31, 2024
Laboratory
animal
studies
have
reported
the
biliary
excretion
of
chemicals
following
exposure.
Nevertheless,
feces
are
rarely
used
as
a
matrix
in
biomonitoring
chemical
exposures.
In
this
study,
and
urine
from
pet
dogs
cats
were
analyzed
for
presence
45
plasticizers,
environmental
phenols,
31
pesticides.
Thirty-two
analytes
detected
≥70%
feces,
while
up
to
29
frequently
(≥70%)
found
urine.
The
sum
concentrations
all
(∑All)
significantly
higher
than
those
measured
(median:
393–666
ng/g
wet
weight
vs
216–464
ng/mL
urine).
Plasticizers
dominant
class
chemicals,
accounting
81–97%
69–77%
∑All
respectively.
Analyte
paired
exhibited
weak
correlations.
rates
via
calculated
through
reverse
dosimetry
approach.
Low-molecular-weight
phthalates
excreted
predominantly
urine,
whereas
high-molecular-weight
several
organophosphate
triesters
feces.
fecal
parabens,
benzophenones,
bisphenols,
naphthalene,
2,4-dichloronicotinic
acid,
4-nitrophenol
similar
or
urinary
excretion.
Our
results
suggest
that
an
important
exposure
chemicals.
Язык: Английский
Alimentação natural e seus efeitos na saúde intestinal de cães e gatos: Revisão de literatura
Research Society and Development,
Год журнала:
2024,
Номер
13(11), С. e107131147480 - e107131147480
Опубликована: Ноя. 17, 2024
A
alimentação
natural
vem
se
tornando
uma
alternativa
cada
vez
mais
popular
à
ração
comercial
entre
tutores
de
cães
e
gatos,
sendo
associada
a
diversos
benefícios
para
saúde
intestinal
desses
animais.
Esse
tipo
dieta
é
composta
por
alimentos
frescos,
minimamente
processados
e,
frequentemente,
crus,
assemelhar
que
esses
pets
consumiriam
em
um
ambiente
selvagem.
fator
fundamental
o
bem-estar
dos
animais,
pois
influencia
diretamente
digestão,
absorção
nutrientes
resposta
imunológica.
Este
estudo
tem
objetivo
revisar
literatura
científica
existente
sobre
os
efeitos
da
na
microbiota
função
gastrointestinal
gatos.
análise
foca
identificar
padrões
tendências
resultados
diferentes
estudos,
ao
mesmo
tempo
destaca
lacunas
conhecimento
áreas
exigem
pesquisas.
Os
visam
auxiliar
profissionais
veterinários
tomarem
decisões
nutricionais
informadas,
visando
adequada
saudável
pets.