Locus coeruleus activation 'resets' hippocampal event representations and separates adjacent memories DOI Creative Commons
David Clewett, Ringo Huang, Lila Davachi

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 18, 2024

Memories reflect the ebb and flow of experiences, capturing unique meaningful events from our lives. Using a combination functional magnetic resonance imaging (fMRI), neuromelanin imaging, pupillometry, we show that arousal locus coeruleus (LC) activation transform otherwise continuous experiences into distinct episodic memories. As sequences unfold, encountering context shift, or event boundary, triggers LC processes predict later memory separation. Boundaries furthermore promote temporal pattern separation within left hippocampal dentate gyrus, which correlates with heightened responses to those same transition points. We also find neurochemical index prolonged diminished at boundaries, suggesting connection between elevated output impaired processing. These findings align idea initiate neural reset in response significant changes, constructing very episodes define everyday memory.

Язык: Английский

Building and Breaking the Chain: A Model of Reward Prediction Error Integration and Segmentation of Memory DOI
Nina Rouhani, David Clewett, James W. Antony

и другие.

Journal of Cognitive Neuroscience, Год журнала: 2024, Номер 36(11), С. 2401 - 2414

Опубликована: Янв. 1, 2024

Abstract Prediction errors drive reinforcement learning and organize episodic memory into distinct contexts, but do these effects interact? Here, we review the roles of midbrain dopamine, locus coeruleus, hippocampus in event cognition to propose simulate theoretical influence two prediction error signals integrating versus segmenting events memory. We suggest that signed reward can build mental models environments, increasing contextual similarity (integration) experiences with stronger, more stable expectations. On other hand, unsigned signal a new model environment, generating shift (segmentation) between crossed them. moreover predicted differences give rise patterns temporal-order combined ideas computational account for seemingly paradoxical pattern where greater representational distance helps order within context impairs it across contexts. found simulating integration segmentation differentially enabled perform associative chaining, which involved reactivating items tested probes assist sequential retrieval. In summary, our simulations provide unifying explanation varied ways neuromodulatory systems may alter

Язык: Английский

Процитировано

1
Distortion of overlapping memories relates to arousal and anxiety DOI

Erin Morrow,

David Clewett

Cognitive Affective & Behavioral Neuroscience, Год журнала: 2024, Номер 25(1), С. 154 - 172

Опубликована: Окт. 8, 2024

Язык: Английский

Процитировано

1
Locus coeruleus activation 'resets' hippocampal event representations and separates adjacent memories DOI Creative Commons
David Clewett, Ringo Huang, Lila Davachi

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 18, 2024

Memories reflect the ebb and flow of experiences, capturing unique meaningful events from our lives. Using a combination functional magnetic resonance imaging (fMRI), neuromelanin imaging, pupillometry, we show that arousal locus coeruleus (LC) activation transform otherwise continuous experiences into distinct episodic memories. As sequences unfold, encountering context shift, or event boundary, triggers LC processes predict later memory separation. Boundaries furthermore promote temporal pattern separation within left hippocampal dentate gyrus, which correlates with heightened responses to those same transition points. We also find neurochemical index prolonged diminished at boundaries, suggesting connection between elevated output impaired processing. These findings align idea initiate neural reset in response significant changes, constructing very episodes define everyday memory.

Язык: Английский

Процитировано

0