Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish
Опубликована: Фев. 10, 2025
Dysregulation
of
sleep
has
widespread
health
consequences
and
represents
an
enormous
burden.
Short-sleeping
individuals
are
predisposed
to
the
effects
neurodegeneration,
suggesting
a
critical
role
for
in
maintenance
neuronal
health.
While
on
cellular
function
not
completely
understood,
growing
evidence
identified
association
between
loss
DNA
damage,
raising
possibility
that
facilitates
efficient
repair.
The
Mexican
tetra
fish,
Astyanax
mexicanus
provides
model
investigate
evolutionary
basis
changes
loss.
Multiple
cave-adapted
populations
these
fish
have
evolved
substantially
less
time
compared
surface
same
species
without
identifiable
impacts
healthspan
or
longevity.
To
whether
is
associated
with
damage
stress,
we
Damage
Response
(DDR)
oxidative
stress
levels
A.
populations.
We
measured
markers
chronic
discovered
elevated
marker
γH2AX
brain,
increased
gut
cavefish,
consistent
deprivation.
Notably,
found
acute
UV-induced
elicited
increase
but
cavefish.
On
transcriptional
level,
only
activated
photoreactivation
repair
pathway
following
UV
damage.
These
findings
suggest
reduction
DDR
cavefish
coincides
examine
pathways
at
created
embryonic
fibroblast
cell
line
from
two
.
observed
both
were
diminished
cells,
corroborating
vivo
response
lost
long-term
impact
changes,
transcriptome
brain
aged
Strikingly,
many
genes
differentially
expressed
young
old
do
transcriptionally
vary
by
age
Taken
together,
developed
resilience
loss,
despite
possessing
hallmarks
Язык: Английский
Isotopic variability of δ13C and δ15N signals in cave systems: insights from the blind tetra Astyanax mexicanus
Subterranean Biology,
Год журнала:
2025,
Номер
51, С. 31 - 47
Опубликована: Март 17, 2025
Stable
isotope
analysis
allows
the
study
of
element
cycles
in
ecosystems
and
trophic
ecology.
δ
13
C
reflects
diversity
primary
productivity,
while
15
N
is
a
good
indicator
levels
organisms.
Caves
have
limited
resources
due
to
absence
light,
reducing
chains
these
ecosystems.
These
extreme
conditions
impose
strong
selection
pressures
on
cave-dwelling
organisms,
known
as
troglobites,
which
exhibit
specific
adaptations
such
vision
pigment
loss,
metabolic
physiological
differences
with
their
surface
counterparts.
The
species
Astyanax
mexicanus
corresponds
model
organism
regressive
evolution,
presents
two
different
ecotypes,
widely
distributed
morph,
morph
present
at
least
34
caves
three
karst
regions
San
Luis
Potosí
Tamaulipas,
Mexico.
In
study,
we
characterized
seven
cave
populations
A.
,
corresponding
regions:
Sierra
de
El
Abra
Guatemala,
representing
distinct
genetic
cavefish
lineages.
We
also
developed
Nutrient
Input
Index
(NI),
assess
whether
geomorphology
influences
resource
availability.
found
isotopic
between
analyzed.
showed
higher
values
wider
niche
ranges
compared
those
reflecting
more
complex
network
tentatively
associated
its
geological
history.
addition,
relationship
was
observed
proximity
pools
values,
could
suggest
NI
directly
geomorphology,
impacting
selective
forces
across
systems.
Язык: Английский
Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 21, 2024
Dysregulation
of
sleep
has
widespread
health
consequences
and
represents
an
enormous
burden.
Short-sleeping
individuals
are
predisposed
to
the
effects
neurodegeneration,
suggesting
a
critical
role
for
in
maintenance
neuronal
health.
While
on
cellular
function
not
completely
understood,
growing
evidence
identified
association
between
loss
DNA
damage,
raising
possibility
that
facilitates
efficient
repair.
The
Mexican
tetra
fish,
Язык: Английский