Harnessing the Role of ESR1 in Breast Cancer: Correlation with microRNA, lncRNA, and Methylation DOI Open Access
Shengping Yang, Claudio Manna, Pulak R. Manna

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3101 - 3101

Опубликована: Март 27, 2025

Breast cancer (BC) is a multifactorial condition and it primarily expresses the estrogen receptor α (ERα) that encoded by gene 1 (ESR1), which modulates signaling. ESR1, facilitating overproduction, plays an indispensable role in progression survival of majority BCs. To obtain molecular insights into these phenomena, we analyzed The Cancer Genome Atlas (TCGA) breast invasive carcinoma (BRCA) RNA-Seq datasets for expression ESR1 its correlation to microRNAs (miRNAs) long non-coding RNAs (lncRNAs), along with methylation patterns. Regulation was also assessed total 43 cancerous non-cancerous cell lines. Analyses both TCGA BRCA line data revealed specific lncRNAs, i.e., MEG3, BIK, MLL, FAS are negatively correlated PARP1 demonstrates positive association. Additionally, miR-30a miR-145 showed negative correlations expression. Of 54 loci analyzed, them exhibited expression, highlighting potentially modifiable regulatory mechanism. These findings underscore complex events influencing interaction diverse signaling pathways, demonstrating novel pathogenesis potential therapeutics.

Язык: Английский

Harnessing the Role of ESR1 in Breast Cancer: Correlation with microRNA, lncRNA, and Methylation DOI Open Access
Shengping Yang, Claudio Manna, Pulak R. Manna

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3101 - 3101

Опубликована: Март 27, 2025

Breast cancer (BC) is a multifactorial condition and it primarily expresses the estrogen receptor α (ERα) that encoded by gene 1 (ESR1), which modulates signaling. ESR1, facilitating overproduction, plays an indispensable role in progression survival of majority BCs. To obtain molecular insights into these phenomena, we analyzed The Cancer Genome Atlas (TCGA) breast invasive carcinoma (BRCA) RNA-Seq datasets for expression ESR1 its correlation to microRNAs (miRNAs) long non-coding RNAs (lncRNAs), along with methylation patterns. Regulation was also assessed total 43 cancerous non-cancerous cell lines. Analyses both TCGA BRCA line data revealed specific lncRNAs, i.e., MEG3, BIK, MLL, FAS are negatively correlated PARP1 demonstrates positive association. Additionally, miR-30a miR-145 showed negative correlations expression. Of 54 loci analyzed, them exhibited expression, highlighting potentially modifiable regulatory mechanism. These findings underscore complex events influencing interaction diverse signaling pathways, demonstrating novel pathogenesis potential therapeutics.

Язык: Английский

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