Ageing & Longevity,
Год журнала:
2025,
Номер
1.2025, С. 6 - 21
Опубликована: Янв. 17, 2025
Neuroglia
of
the
central
nervous
system,
represented
by
astroglia,
oligodendroglia
and
microglia,
are
fundamental
for
life-long
support
homeostasis,
plasticity
defence
neural
tissue.
In
particular
neuroglial
cells
contribute
to
cognitive
reserve,
which
defines
neurological
outcome
both
physiological
pathological
ageing.
Physiological
ageing
is
accompanied
with
structural
functional
decline
neuroglia.
particular,
astrocytes
undergo
morphological
atrophy
asthenia
compromises
their
vital
functions
such
as
glutamate
clearance,
K+
buffering
synaptic
support.
Old
oligodendrocytes
lose
myelination
capacity,
results
in
thinning
myelin
sheath
white
matter.
Finally,
associated
accumulation
dystrophic
microglia
limits
neuroprotection.
Age-dependent
impedes
contributes
impairment,
increases
vulnerability
system
neurodegeneration.
Life
style
changes
positively
impact
on
structure
function
this
improving
longevity.
Keywords:
ageing;
longevity;
neuroglia,
oligodendroglia;
oligodendroglial
precursor
cells;
Cells,
Год журнала:
2021,
Номер
10(3), С. 540 - 540
Опубликована: Март 4, 2021
Astrocytes
perform
a
wide
variety
of
essential
functions
defining
normal
operation
the
nervous
system
and
are
active
contributors
to
pathogenesis
neurodegenerative
disorders
such
as
Alzheimer’s
among
others.
Recent
data
provide
compelling
evidence
that
distinct
astrocyte
states
associated
with
specific
stages
Alzheimer´s
disease.
The
advent
transcriptomics
technologies
enables
rapid
progress
in
characterisation
pathological
states.
In
this
review,
we
an
overview
origin,
main
functions,
molecular
morphological
features
astrocytes
physiological
well
conditions
related
We
will
also
explore
roles
disease
summarize
transcriptional
changes
altered
pathways
observed
during
course
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(10), С. 5404 - 5404
Опубликована: Май 12, 2022
Alzheimer's
disease
(AD)
constitutes
the
most
prominent
form
of
dementia
among
elderly
individuals
worldwide.
Disease
modeling
using
murine
transgenic
mice
was
first
initiated
thanks
to
discovery
heritable
mutations
in
amyloid
precursor
protein
(APP)
and
presenilins
(PS)
genes.
However,
due
repeated
failure
translational
applications
from
animal
models
human
patients,
along
with
recent
advances
genetic
susceptibility
our
current
understanding
on
biology,
these
have
evolved
over
time
an
attempt
better
reproduce
complexity
this
devastating
improve
their
applicability.
In
review,
we
provide
a
comprehensive
overview
about
major
pathological
elements
AD
(plaques,
tauopathy,
synaptic
damage,
neuronal
death,
neuroinflammation
glial
dysfunction),
discussing
knowledge
that
available
mouse
provided
mechanisms
underlying
disease.
Moreover,
highlight
pros
cons
models,
revolution
offered
by
concomitant
use
omics
technologies
may
lead
more
rapid
improvement
present
battery.
Ageing & Longevity,
Год журнала:
2025,
Номер
1.2025, С. 6 - 21
Опубликована: Янв. 17, 2025
Neuroglia
of
the
central
nervous
system,
represented
by
astroglia,
oligodendroglia
and
microglia,
are
fundamental
for
life-long
support
homeostasis,
plasticity
defence
neural
tissue.
In
particular
neuroglial
cells
contribute
to
cognitive
reserve,
which
defines
neurological
outcome
both
physiological
pathological
ageing.
Physiological
ageing
is
accompanied
with
structural
functional
decline
neuroglia.
particular,
astrocytes
undergo
morphological
atrophy
asthenia
compromises
their
vital
functions
such
as
glutamate
clearance,
K+
buffering
synaptic
support.
Old
oligodendrocytes
lose
myelination
capacity,
results
in
thinning
myelin
sheath
white
matter.
Finally,
associated
accumulation
dystrophic
microglia
limits
neuroprotection.
Age-dependent
impedes
contributes
impairment,
increases
vulnerability
system
neurodegeneration.
Life
style
changes
positively
impact
on
structure
function
this
improving
longevity.
Keywords:
ageing;
longevity;
neuroglia,
oligodendroglia;
oligodendroglial
precursor
cells;
