Salt Tolerant Microbes (Active Metabolites) Mediated Nanoparticle: Drug Delivery and Future Prospects DOI Creative Commons

Priya,

Poonam Joshi, Jaya Rautela

и другие.

Journal of Pure and Applied Microbiology, Год журнала: 2024, Номер 18(2), С. 853 - 866

Опубликована: Июнь 1, 2024

Salt Tolerant Microbes are a group of microorganisms that grow, develop, and survive in extremely high salt concentrations. Based on their tolerance level they generally grow up optimally at pH values beyond 9.0, but the growth is inhibited value most closely associated with neutral 6.5. They have minimal dietary needs good quantity enough to osmotic pressure. can produce biological metabolites certain actions such as antibacterial, antifungal, antioxidant, anticancer. We discussed this article various pharmaceutical formulations salt-tolerant microbes, every formulation shows specific pharmacological like anti-cancer activity, anti-oxidant anti-microbial also discusses methods for biosynthesis microbes’ nanoparticles.

Язык: Английский

Taxonomic Identification, Complete Genome Sequencing, and In Silico Genome Mining of the Actinobacterium Lentzea sp. JNUCC 0626 Isolated from Jeju Gotjawal DOI Open Access
Kyung‐A Hyun, Kyung-Hwan Boo, Chang‐Gu Hyun

и другие.

Deleted Journal, Год журнала: 2025, Номер 70(1), С. 8 - 8

Опубликована: Фев. 7, 2025

In our previous study, Lentzea sp. JNUCC 0626 was isolated from Hwasun Gotjawal on Jeju Island, and its melanogenic effects were confirmed in B16F10 melanoma cells through the identification of 1-acetyl-β-carboline. this we conducted a comprehensive taxonomic characterization 0626, including enzymatic activities, carbohydrate metabolism, growth conditions, cellular composition. Major fatty acids identified iso-C16:0, iso-C15:0, C15:0 anteiso, with polar lipids such as diphosphatidylglycerol, phosphatidylethanolamine, several unidentified lipids. Ubiquinone Q-9 determined predominant respiratory quinone. Enzymatic activity analysis (API ZYM) showed alkaline phosphatase, esterase (C4), lipase (C8), leucine arylamidase while metabolism 50CHB) indicated acid production esculin alone. Complete genome sequencing revealed 10,602,950 bp linear chromosome 177,940 plasmid. This plasmid encodes essential plasmid-related genes, Type IV secretion system ParA proteins critical for transfer stability. These findings suggest that could be utilized developing host–vector systems to facilitate combinatorial biosynthesis novel bioactive compounds. Comparative genomic pudingi CGMCC 4.7319 closest relative, but significant genetic divergence (dDDH 46.7%, ANI 88.02%) strongly supports classification species. AntiSMASH 34 biosynthetic gene clusters (BGCs), highlighting strain’s capacity produce diverse Finally, extract exhibited concentration-dependent NO inhibition LPS-stimulated RAW 264.7 cells, demonstrating anti-inflammatory activity. suggests secondary metabolites inferred may contribute these observed bioactivities.

Язык: Английский

Процитировано

0

Unique microbial communities in ancient volcanic ash layers within deep marine sediments are structured by the composition of iron phases DOI Creative Commons

Sönke Rolfes,

Jack Longman, Katharina Pahnke

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Март 12, 2025

Much of the marine sedimentary environment is affected by deposition tephra, explosive products volcanic eruptions. These tephra layers’ geochemical and physical properties often differ substantially from those surrounding sediment, forming an extreme carbon-lean within anoxic deep biosphere. Despite this, evidence suggests layers harbor diverse abundant microbial communities. While little known about composition these communities even less their life modes, there indicating that iron (Fe) plays a vital role for microorganisms. Here, we aim to link differences in content sediments with changes We combined next-generation sequencing 16S rRNA genes analyses Fe phases preserved ancient recovered Norwegian Margin during Expedition 396 International Ocean Discovery Program (IODP). In samples, basaltic contained nearly double total as sediments, majority hosted “reducible” Fe(III) oxides, whilst primarily “easily reducible” oxides. Basaltic harbored distinct differed sediment predicted metabolic properties. predictions suggest higher potential assimilatory use more complex sources microbes are able exploit found high quantities layers. Our findings confirm few previous studies have suggested occur Deciphering indigenous microorganisms hints at how might flourish this environment. This has implications understanding ubiquitous component

Язык: Английский

Процитировано

0

Borrelidin M: a new borrelidin derivative obtained from Streptomyces rochei VL-16 exhibited potent antibacterial and antiproliferative properties DOI

Vinoth Vengadesan,

Jagan Muniyandi,

Neha Yadav

и другие.

International Microbiology, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0

Decylprodigiosin: a new member of the prodigiosin family isolated from a seaweed-associated Streptomyces DOI Creative Commons
Mariana Girão, Sara Freitas, Teresa P. Martins

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Март 21, 2024

Bioprospecting actinobacterial secondary metabolism from untapped marine sources may lead to the discovery of biotechnologically-relevant compounds. While studying diversity and bioactive potential Actinomycetota associated with Codium tomentosum, a green seaweed collected in northern Portuguese cost, strain CT-F61, identified as Streptomyces violaceoruber , was isolated. Its extracts displayed strong anticancer activity on breast carcinoma T-47D colorectal HCT116 cells, being effective well against panel human fish pathogenic bacteria. Following bioactivity-guided isolation pipeline, new analogue red-pigmented family antibiotics prodigiosins, decylprodigiosin (1), chemically characterized. Despite this natural products well-known for long time, we report first evidence prodigiosins produced by seaweed-associated actinomycete.

Язык: Английский

Процитировано

2

Cellulamides: A New Family of Marine-Sourced Linear Peptides from the Underexplored Cellulosimicrobium Genus DOI Creative Commons
Mariana Girão,

José Murillo-Alba,

Jesús Martı́n

и другие.

Marine Drugs, Год журнала: 2024, Номер 22(6), С. 268 - 268

Опубликована: Июнь 11, 2024

Bioprospecting the secondary metabolism of underexplored Actinomycetota taxa is a prolific route to uncover novel chemistry. In this work, we report isolation, structure elucidation, and bioactivity screening cellulamides A B (1 2), two linear peptides obtained from culture macroalga-associated Cellulosimicrobium funkei CT-R177. The host microorganism, Chlorophyta Codium tomentosum, was collected in northern Portuguese coast and, scope bioprospecting study focused on its associated actinobacterial community, strain CT-R177 isolated, taxonomically identified, screened for production antimicrobial anticancer compounds. Dereplication crude extract using LC-HRMS(/MS) analysis unveiled putative natural product, cellulamide (1), that isolated following mass spectrometry-guided fractionation. An additional analog, (2) during chromatographic process chemically characterized. chemical structures peptides, including their absolute configurations, were elucidated combination HRMS, 1D/2D NMR spectroscopy, Marfey’s analysis. Cellulamide (1) subjected set screenings, but no significant biological activity observed. represent first family products reported genus Cellulosimicrobium, showcasing not only potential less-explored also host-associated marine strains chemistry discovery.

Язык: Английский

Процитировано

1

Salt Tolerant Microbes (Active Metabolites) Mediated Nanoparticle: Drug Delivery and Future Prospects DOI Creative Commons

Priya,

Poonam Joshi, Jaya Rautela

и другие.

Journal of Pure and Applied Microbiology, Год журнала: 2024, Номер 18(2), С. 853 - 866

Опубликована: Июнь 1, 2024

Salt Tolerant Microbes are a group of microorganisms that grow, develop, and survive in extremely high salt concentrations. Based on their tolerance level they generally grow up optimally at pH values beyond 9.0, but the growth is inhibited value most closely associated with neutral 6.5. They have minimal dietary needs good quantity enough to osmotic pressure. can produce biological metabolites certain actions such as antibacterial, antifungal, antioxidant, anticancer. We discussed this article various pharmaceutical formulations salt-tolerant microbes, every formulation shows specific pharmacological like anti-cancer activity, anti-oxidant anti-microbial also discusses methods for biosynthesis microbes’ nanoparticles.

Язык: Английский

Процитировано

0