Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format DOI Creative Commons
Tatiana M. Zimina, Nikita O. Sitkov,

Ksenia E. Brusina

и другие.

Nanomaterials, Год журнала: 2024, Номер 14(24), С. 2030 - 2030

Опубликована: Дек. 17, 2024

This study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs enhancing their specificity to pathological cells through chemical modifications, personalized adjustments, highlighting the potential of tumor-on-a-chip systems, which can simulate tissue environments assess drug efficacy dosage a setting. The research focused on two MNP types, uncoated magnetite nanoparticles (mMNPs) carboxymethyl dextran coated superparamagnetic (CD-SPIONs), evaluated transport properties microfluidic systems porous media. original mMNPs bimodal size distribution narrow fractions (23 nm 106 by radii) were demonstrated agglomerate magnetically driven flow, forming stationary web consisting fibers within 30 min. CD-SPIONs migrate agar gel with mean pore equal or slightly higher than size. migration velocity was inversely proportional particles. No compression observed under field gradient 40 T/m. In brain tissue, particles sizes 220, 350, 820 not penetrating while observed. 95 penetrated at edge sample, no For all particles, movement capillary vessels

Язык: Английский

Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format DOI Creative Commons
Tatiana M. Zimina, Nikita O. Sitkov,

Ksenia E. Brusina

и другие.

Nanomaterials, Год журнала: 2024, Номер 14(24), С. 2030 - 2030

Опубликована: Дек. 17, 2024

This study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs enhancing their specificity to pathological cells through chemical modifications, personalized adjustments, highlighting the potential of tumor-on-a-chip systems, which can simulate tissue environments assess drug efficacy dosage a setting. The research focused on two MNP types, uncoated magnetite nanoparticles (mMNPs) carboxymethyl dextran coated superparamagnetic (CD-SPIONs), evaluated transport properties microfluidic systems porous media. original mMNPs bimodal size distribution narrow fractions (23 nm 106 by radii) were demonstrated agglomerate magnetically driven flow, forming stationary web consisting fibers within 30 min. CD-SPIONs migrate agar gel with mean pore equal or slightly higher than size. migration velocity was inversely proportional particles. No compression observed under field gradient 40 T/m. In brain tissue, particles sizes 220, 350, 820 not penetrating while observed. 95 penetrated at edge sample, no For all particles, movement capillary vessels

Язык: Английский

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