The protective and chemotherapeutical role of amygdalin in induced mammary cancer in experimental mice and upregulation of related genes DOI Creative Commons

Afaf D. Abdel Mageid,

Ibrahim M. Abdel-Wadoud,

Elsayed I. Salim

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 17, 2025

Abstract Breast cancer is a prominent health issue among oncological diseases in emerging nations. The study sought to assess the significant function of amygdalin as protective and chemotherapeutical substance combating this lethal condition, either independently or conjunction with tamoxifen therapy. mice was induced by 7,12-Dimethylbenz(a)anthracene (DMBA). Mice were divided into six groups, 15 each group. (i) control group, (ii) carcinogenic (iii) tamoxifen-treated (iv) Amygdalin-treated (v) (Amygdalin + tamoxifen) (vi) Amygdalin Results revealed that DMBA-induced breast caused increase biochemical parameters such CEA, CA15.3, CA125, PRL, E2, urea, creatinine, ALT, AST, ALP substantial gene expression TNF-α BcL-2. In contrast, administrations alone co-administration could ameliorate declining TNF-α, BcL-2 attenuating parameters. showed SOD GPx antioxidants upregulation Caspase-3 P53 tissue. Moreover, flow cytometric analysis correlated CD20 CD44 promoted cell cycle apoptosis mice. Indeed, above results confirmed histopathological examinations, which DMBA group had proliferated microductular carcinoma marked mononuclear inflammatory infiltration, decreased administrations. conclusion, administration may be effective preventing exhibiting chemotherapeutic properties.

Язык: Английский

The protective and chemotherapeutical role of amygdalin in induced mammary cancer in experimental mice and upregulation of related genes DOI Creative Commons

Afaf D. Abdel Mageid,

Ibrahim M. Abdel-Wadoud,

Elsayed I. Salim

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 17, 2025

Abstract Breast cancer is a prominent health issue among oncological diseases in emerging nations. The study sought to assess the significant function of amygdalin as protective and chemotherapeutical substance combating this lethal condition, either independently or conjunction with tamoxifen therapy. mice was induced by 7,12-Dimethylbenz(a)anthracene (DMBA). Mice were divided into six groups, 15 each group. (i) control group, (ii) carcinogenic (iii) tamoxifen-treated (iv) Amygdalin-treated (v) (Amygdalin + tamoxifen) (vi) Amygdalin Results revealed that DMBA-induced breast caused increase biochemical parameters such CEA, CA15.3, CA125, PRL, E2, urea, creatinine, ALT, AST, ALP substantial gene expression TNF-α BcL-2. In contrast, administrations alone co-administration could ameliorate declining TNF-α, BcL-2 attenuating parameters. showed SOD GPx antioxidants upregulation Caspase-3 P53 tissue. Moreover, flow cytometric analysis correlated CD20 CD44 promoted cell cycle apoptosis mice. Indeed, above results confirmed histopathological examinations, which DMBA group had proliferated microductular carcinoma marked mononuclear inflammatory infiltration, decreased administrations. conclusion, administration may be effective preventing exhibiting chemotherapeutic properties.

Язык: Английский

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