Brain Research, Год журнала: 2024, Номер unknown, С. 149400 - 149400
Опубликована: Дек. 1, 2024
Язык: Английский
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Май 10, 2025
Язык: Английский
Процитировано
1
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 12, 2025
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 5, 2025
The intricate pathogenesis of epilepsy, characterized by abnormal neuronal discharges and neuroinflammation, underscores the critical involvement adenosine triphosphate (ATP)-P2X purinoceptor 7 (P2 × 7) receptor pathway in inflammation activation. To address this, a reactive oxygen species (ROS)/electric-responsive d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-ferrocene-poloxamer nanomicelle (TFP@A) was engineered to deliver P2 antagonist A 438,079, aiming provide targeted therapeutic strategy for epilepsy management. study meticulously designed TFP@A precise drug delivery through various techniques including transmission electron microscopy (TEM), dynamic light scattering (DLS), high-performance liquid chromatography (HPLC). Cellular uptake blood-brain barrier (BBB) permeability were evaluated using fluorescein isothiocyanate (FITC)-labeled vitro brain endothelial cell line (bEnd.3) BBB model. In vivo distribution safety assessments conducted an mouse impact on investigated seizure analysis, electroencephalogram (EEG) recordings, inflammatory assessment. exhibited robust release profile under ROS electrical stimulation conditions. studies demonstrated its efficacy scavenging ROS, reducing oxidative stress, alleviating apoptosis models. Efficient cellular uptake, penetration, accumulation observed. Notably, effectively modulated 7R)-nucleotide-binding oligomerization domain-like family pyrin domain-containing 3 (NLRP3) pathway, inhibiting mediators promoting anti-inflammatory responses. loaded with showcases potential benefits suppressing NLRP3 inflammasome activation, mitigating microglial-neuron crosstalk, ameliorating symptoms, positioning it as promising avenue treatment.
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Май 6, 2025
Язык: Английский
Процитировано
0
Advances in medical diagnosis, treatment, and care (AMDTC) book series, Год журнала: 2025, Номер unknown, С. 411 - 440
Опубликована: Янв. 3, 2025
Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen. In the context of neurodegenerative disorders, ROS play a dual role while they necessary for normal cellular function, their overproduction can lead to oxidative stress, damaging neurons and contributing pathogenesis diseases such as Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis (ALS). This book chapter explores mechanisms by which contributes neurodegeneration, including mitochondrial dysfunction, protein aggregation, inflammation. Additionally, we discuss current emerging therapeutic strategies aimed at modulating levels mitigating damage, antioxidants, gene therapy, lifestyle interventions. Understanding balance between production antioxidant defenses is crucial developing effective treatments diseases.
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Май 9, 2025
Язык: Английский
Процитировано
0
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Май 30, 2025
Язык: Английский
Процитировано
0
Brain Research, Год журнала: 2024, Номер unknown, С. 149400 - 149400
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
2