Frontiers in Human Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Фев. 3, 2025
As
life
becomes
more
stressful,
neurological
disorders,
psychiatric
and
comorbidities
of
the
two
are
becoming
a
concern.
Multiple
neuropsychiatric
disorders
share
same
mental
somatic
dysfunction
may
involve
common
brain
circuits
mechanistic
targets.
Music
therapy,
as
an
art
form
with
proven
efficacy,
low
cost
few
side
effects,
is
promoted
for
use
in
interventions
disorders.
This
be
closely
related
to
release
signaling
molecules
such
monoamine
neurotransmitters,
glutamatergic
system,
gut-microbiota-brain
axis,
pro-inflammatory
cytokines
endogenous
opioid
peptide
system.
However,
fewer
studies
have
mentioned
main
targets
music
promote
functional
changes
regions.
Therefore,
this
paper
review
mechanisms
by
which
therapy
interacts
prefrontal
cortex-hippocampus-amygdala
circuit
through
aforementioned
molecules.
It
also
hypothesized
that
glial
cells,
mitochondria
microRNAs
microscopic
musical
intervention
The
aim
give
new
ideas
future
research
into
biological
Exploration of Neuroprotective Therapy,
Год журнала:
2023,
Номер
unknown, С. 207 - 234
Опубликована: Авг. 25, 2023
Parkinson’s
disease
(PD)
is
a
prevalent
neurodegenerative
(NDD)
affecting
millions
of
individuals.
The
pathogenesis
PD
centers
around
α-synuclein
(α-Syn),
pivotal
protein
whose
aggregation
significantly
impacts
progression.
Although
existing
treatments
mainly
focus
on
managing
motor
symptoms
by
targeting
the
dopaminergic
system,
they
frequently
overlook
other
non-motor
symptoms.
intricate
nature
contributes
to
challenges
in
analysis
and
has
hindered
development
effective
treatments.
In
recent
years,
various
novel
therapies
utilizing
immunotherapy
methods
have
exhibited
promise
preclinical
animal
models.
NDDs,
aims
counteract
detrimental
effects
accumulation
neutralizing
toxic
species
aiding
their
elimination.
Numerous
active
therapy
(AI)
passive
(PI)
strategies
been
devised
for
related
synucleinopathies,
many
which
are
currently
undergoing
clinical
trials.
Despite
demonstrating
remarkable
success
models,
immunotherapies
encountered
substantial
setbacks
during
late
stages
trials,
with
exception
lecanemab,
targets
amyloid-β
(Aβ)
Alzheimer’s
(AD)
recently
received
approval
from
Food
Drug
Administration
(FDA).
lack
translation
experimental
investigations
successful
outcomes,
particularly
terms
cognitive
functional
evaluations,
highlights
limitations
relying
solely
studies
comprehend
immunotherapeutic
approaches.
This
comprehensive
review
focuses
α-Syn-based
delves
into
underlying
mechanisms
action.
Furthermore,
article
discusses
advancements
future
prospects
concerning
potential
PD.
highlighting
latest
research
this
domain
illuminate
opportunities
efficacious
individuals
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Ноя. 1, 2024
The
prevalence
of
neurodegenerative
disorders
such
as
Parkinson's
disease
are
increasing
world
populations
age.
Despite
this
growing
public
health
concern,
the
precise
molecular
and
cellular
mechanisms
that
culminate
in
neurodegeneration
remain
unclear.
Effective
treatment
options
for
other
very
limited,
due
part
to
uncertain
etiology.
One
commonality
across
diseases
is
sustained
neuroinflammation,
mediated
large
by
microglia,
innate
immune
cells
brain.
Initially
thought
simply
react
neuron-derived
pathology,
genetic
functional
studies
recent
years
suggest
microglia
play
a
more
active
role
process
than
previously
appreciated.
Here,
we
review
evidence
roles
pathogenesis
progression,
with
particular
focus
on
microglial
functions
perturbed
associated
genes
mutations.
Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(11)
Опубликована: Ноя. 15, 2024
Glial
cells,
including
astrocytes
and
microglia,
are
pivotal
in
maintaining
central
nervous
system
(CNS)
homeostasis
responding
to
pathological
insults.
This
review
elucidates
the
complex
immunomodulatory
functions
of
glial
with
a
particular
focus
on
their
involvement
inflammation
cascades
initiated
by
accumulation
alpha-synuclein
(α-syn),
hallmark
Parkinson’s
disease
(PD).
Deriving
insights
from
studies
both
sporadic
familial
forms
PD,
as
well
animal
models
we
explore
how
cells
contribute
progression
triggered
α-syn
aggregation.
Additionally,
analyze
interplay
between
blood-brain
barrier
(BBB),
highlighting
role
these
BBB
integrity
permeability
context
PD
pathology.
Furthermore,
delve
into
potential
activation
repair
neuroprotective
mechanisms
mediated
amidst
α-syn-induced
neuroinflammation.
By
integrating
information
dynamics,
this
aims
deepen
our
understanding
multifaceted
interactions
pathology,
CNS
inflammation,
thereby
offering
valuable
therapeutic
strategies
for
related
neurodegenerative
disorders.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 3, 2025
The
main
characteristics
of
Parkinson's
disease
(PD)
are
the
loss
dopaminergic
(DA)
neurons
and
abnormal
aggregation
cytosolic
proteins.
However,
exact
pathogenesis
PD
remains
unclear,
with
ferroptosis
emerging
as
one
key
factors
driven
by
iron
accumulation
lipid
peroxidation.
Glial
cells,
including
microglia,
astrocytes,
oligodendrocytes,
serve
supportive
cells
in
central
nervous
system
(CNS),
but
their
activation
can
lead
to
DA
neuron
death
ferroptosis.
This
paper
explores
interactions
between
glial
neurons,
reviews
changes
during
pathological
process
PD,
reports
on
how
regulate
through
homeostasis
opens
up
a
new
pathway
for
basic
research
therapeutic
strategies
disease.
Frontiers in Human Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Фев. 3, 2025
As
life
becomes
more
stressful,
neurological
disorders,
psychiatric
and
comorbidities
of
the
two
are
becoming
a
concern.
Multiple
neuropsychiatric
disorders
share
same
mental
somatic
dysfunction
may
involve
common
brain
circuits
mechanistic
targets.
Music
therapy,
as
an
art
form
with
proven
efficacy,
low
cost
few
side
effects,
is
promoted
for
use
in
interventions
disorders.
This
be
closely
related
to
release
signaling
molecules
such
monoamine
neurotransmitters,
glutamatergic
system,
gut-microbiota-brain
axis,
pro-inflammatory
cytokines
endogenous
opioid
peptide
system.
However,
fewer
studies
have
mentioned
main
targets
music
promote
functional
changes
regions.
Therefore,
this
paper
review
mechanisms
by
which
therapy
interacts
prefrontal
cortex-hippocampus-amygdala
circuit
through
aforementioned
molecules.
It
also
hypothesized
that
glial
cells,
mitochondria
microRNAs
microscopic
musical
intervention
The
aim
give
new
ideas
future
research
into
biological
