Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial

Nature Medicine, Год журнала: 2020, Номер 26(11), С. 1733 - 1741

Опубликована: Сен. 7, 2020

Язык: Английский

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Re‐evaluation of insect melanogenesis research: Views from the dark side

Pigment Cell & Melanoma Research, Год журнала: 2017, Номер 30(4), С. 386 - 401

Опубликована: Апрель 5, 2017

Melanins (eumelanin and pheomelanin) are synthesized in insects for several purposes including cuticle sclerotization color patterning, clot formation, organogenesis, innate immunity. Traditional views of insect immunity detail the storage pro-phenoloxidases inside specialized blood cells (hemocytes) their release upon recognition foreign bodies. Activated phenoloxidases convert monophenols into reactive quinones a two-step enzymatic reaction, until recently, mechanism tyrosine hydroxylation remained mystery. Herein, we present our interpretations these enzyme-substrate complexes. The resultant melanins deposited onto surface microbes to immobilize, agglutinate, suffocate them. Phenoloxidase activity melanin production not limited (hemolymph) or cuticle, as recent evidence points more diverse, sophisticated interactions gut with resident symbionts. This review offers insight somewhat neglected areas melanogenesis research, particularly immunity, its role beneficial such pollinators, functional versatility phenoloxidases, limitations common experimental approaches that may impede progress inadvertently.

Язык: Английский

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Genomic Signatures Supporting the Symbiosis and Formation of Chitinous Tube in the Deep-Sea Tubeworm Paraescarpia echinospica

Molecular Biology and Evolution, Год журнала: 2021, Номер 38(10), С. 4116 - 4134

Опубликована: Июль 8, 2021

Vestimentiferan tubeworms are iconic animals that present as large habitat-forming chitinized tube bushes in deep-sea chemosynthetic ecosystems. They gutless and depend entirely on their endosymbiotic sulfide-oxidizing chemoautotrophic bacteria for nutrition. Information the genomes of several siboglinid endosymbionts has improved our understanding nutritional supplies. However, interactions between remain largely unclear due to a paucity host genomes. Here, we report chromosome-level genome vestimentiferan tubeworm Paraescarpia echinospica. We found been remodeled facilitate symbiosis through expansion gene families related substrate transfer innate immunity, suppression apoptosis, regulation lysosomal digestion, protection against oxidative stress. Furthermore, encodes programmed cell death pathway potentially controls endosymbiont population. Our integrated genomic, transcriptomic, proteomic analyses uncovered matrix proteins required formation chitinous revealed family co-option evolutionary mechanisms driving acquisition this unique supporting structure tubeworms. Overall, study provides novel insights into host's support system enabled establish symbiosis, thrive hot vents cold seeps, produce tubes deep sea.

Язык: Английский

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Application of haematology parameters for health management in fish farms

Reviews in Aquaculture, Год журнала: 2022, Номер 15(2), С. 704 - 737

Опубликована: Ноя. 10, 2022

Abstract Farmed fish are a promising source of high‐quality and sustainable protein. However, the production farmed products that meet food safety standards is one major public health challenges worldwide. Therefore, management in farms has recently garnered increasing attention. detection parameters currently lacking. Haematology, an approach widely used humans, provides reliable assessment status non‐lethal low‐cost way. Nevertheless, comprehensive, systemic standard haematological have not yet been established fish. Here, we provide summary recent advancements haematology indicators Generally, based on physiological biochemical indices blood. After global review fish, analysed research progress current trends explored their potential application for healthy farming. Furthermore, discuss internal external environmental factors also affect blood indices. Finally, future Collectively, topics discussed this highlight predictive severely underrated value

Язык: Английский

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The stress–immunity axis in shellfish

Journal of Invertebrate Pathology, Год журнала: 2020, Номер 186, С. 107492 - 107492

Опубликована: Окт. 18, 2020

Язык: Английский

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Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

BMC Genomics, Год журнала: 2018, Номер 19(1)

Опубликована: Май 24, 2018

Aquaculture production is expected to double by 2030, and demands for aquafeeds raw materials are increase accordingly. Sustainable growth of aquaculture will require the development highly nutritive functional efficiently replace fish meal. Enzymatic hydrolysis marine could bring new functionalities finished products. The aim this study was determine zootechnical transcriptomic performances protein hydrolysates different origins (tilapia, shrimp, a combination two) in European seabass (Dicentrarchux labrax) fed low meal diet (5%), 65 days.Results were compared positive control with 20% Growth performances, anterior intestine histological organization responses monitored analyzed. Dietary inclusion restored similar those control. Inclusion dietary shrimp hydrolysate resulted larger villi more goblet cells, even better than Transcriptomic analysis showed that pattern intestinal gene expression very close However, as depending on their origin, did not modulate metabolic pathways same way. modulated related immunity, while nutritional metabolism impacted tilapia hydrolysate. Interestingly, two enhanced benefits diets: genes regulated combined each tested independently.Protein manufactured from by-products promising candidates help feeds without disrupting animal performances.

Язык: Английский

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Factors Affecting the Formation and Treatment of Thrombosis by Natural and Synthetic Compounds

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(21), С. 7975 - 7975

Опубликована: Окт. 27, 2020

Venous thromboembolism (VTE) refers to deep vein thrombosis (DVT), whose consequence may be a pulmonary embolism (PE). Thrombosis is associated with significant morbidity and mortality the third most common cardiovascular disease after myocardial infarction stroke. DVT formation of blood clot in body. promotes slowed flow, hypoxia, cell activation, release many active substances involved formation. All thrombi which adhere endothelium consist fibrin, platelets, trapped red white cells. In this review, we summarise impact various factors affecting haemostatic disorders leading The paper discusses causes thrombosis, mechanism formation, such as involvement endothelial cells (ECs), activation platelets neutrophils along effects bacteria reactive oxygen species (ROS). Mechanisms related action anticoagulants coagulation including antiplatelet drugs have also been discussed. However, aspects pathogenesis still need clarified. A review used treat prevent natural that occur plant world are traditionally Far Eastern medicine has carried out.

Язык: Английский

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Role of Carbon Monoxide in Host–Gut Microbiome Communication

Chemical Reviews, Год журнала: 2020, Номер 120(24), С. 13273 - 13311

Опубликована: Окт. 22, 2020

Nature is full of examples symbiotic relationships. The critical relation between host and mutualistic bacteria attracting increasing attention to the degree that gut microbiome proposed by some as a new organ system. exerts its systemic effect through diverse range metabolites, which include gaseous molecules such H2, CO2, NH3, CH4, NO, H2S, CO. In turn, human can influence these well in reciprocal manner. Among molecules, CO occupy special place because their widely known physiological functions overlap similarity both targets functions. roles NO H2S play have been extensively examined others. Herein, host-gut communication are discussion (1) production function CO, (2) available donors research tools, (3) from diet bacterial sources, (4) on including sensing, (5) There large amount literature suggesting "messenger" role communication. However, much more work needed begin achieving systematic understanding this issue.

Язык: Английский

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Full-length transcriptome analysis of Litopenaeus vannamei reveals transcript variants involved in the innate immune system

Fish & Shellfish Immunology, Год журнала: 2019, Номер 87, С. 346 - 359

Опубликована: Янв. 21, 2019

Язык: Английский

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Improvement of in vivo iron bioavailability using mung bean peptide-ferrous chelate

Food Research International, Год журнала: 2024, Номер 190, С. 114602 - 114602

Опубликована: Июнь 5, 2024

Язык: Английский

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