International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(11), С. 5116 - 5116
Опубликована: Май 26, 2025
The
circadian
clock
orchestrates
nearly
every
aspect
of
physiology,
aligning
metabolic
processes
with
environmental
cues,
such
as
light
and
food
intake.
While
the
central
pacemaker
in
suprachiasmatic
nucleus
synchronizes
peripheral
clocks
across
key
tissue,
feeding
behavior
emerges
dominant
cue
for
alignment.
This
interaction
reveals
a
crucial
link
between
biology
metabolism.
Disruption
these
processes,
whether
from
shift
work,
irregular
eating
patterns
or
lifestyle
misalignment,
has
been
strongly
associated
disorders,
including
obesity,
insulin
resistance
cardiometabolic
diseases.
Within
field
chrononutrition,
strategies,
time-restricted
(TRF),
have
gained
attention
their
potential
to
restore
alignment
improve
health.
However,
translational
gaps
persist,
most
mechanistic
insights
are
derived
nocturnal
murine
models,
limiting
applicability
diurnal
human
physiology.
Moreover,
studies
confounded
by
interindividual
variability
chronotype,
behavioral
patterns,
dietary
compliance.
review
explores
molecular
underpinnings
zeitgeber
signals
critically
assesses
barriers
implementing
chrononutrition
species.
By
integrating
both
preclinical
clinical
research,
we
aim
refine
circadian-based
interventions
disease
prevention
personalized
nutrition.
International Journal of Food Sciences and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Апрель 29, 2025
The
consumption
of
grape
seed
procyanidin
extract
(GSPE)
may
improve
metabolic
alterations
and
molecular
clock
desynchrony
in
white
adipose
tissue
(WAT),
depending
on
administration
timing
status.
To
test
this
hypothesis,
inguinal
WAT
explants
from
lean
obese
PERIOD2::LUCIFERASE
(PER2::LUC)
circadian
reporter
mice
were
treated
at
the
peak
or
trough
PER2
luminescence
rhythm
with
metabolites
present
serum
GSPE-administered
rats
(GSPM).
PER2::LUC
rhythms
animals
presented
a
lower
amplitude,
longer
period
phase
delay.
GSPM
treatment
increased
amplitude
compared
to
untreated
explants,
but
only
when
it
was
given
luminescence.
upregulated
lipogenesis
lipolysis
genes
mice,
mostly
peak.
This
study
provides
valuable
platform
for
testing
effects
natural
products
ex
vivo
warrants
further
investigation
into
chrono-utilisation
plant
bioactive
compounds.
Frontiers in Cellular Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Май 15, 2025
Behavior
arises
from
coordinated
brain-wide
neural
and
glial
networks,
enabling
organisms
to
perceive,
interpret,
respond
stimuli.
Astrocytes
play
an
important
role
in
shaping
behavioral
output,
yet
the
underlying
molecular
mechanisms
are
not
fully
understood.
intrinsic
extrinsic
cues
with
calcium
(Ca
2+
)
fluctuations,
which
highly
heterogeneous
across
spatio-temporal
scales,
contexts,
brain
regions.
This
heterogeneity
allows
astrocytes
exert
dynamic
regulatory
effects
on
neuronal
function
but
has
made
it
challenging
understand
precise
pathways
linking
astrocytic
Ca
specific
outcomes,
functional
relevance
of
these
signals
remains
unclear.
Here,
we
review
recent
literature
uncovering
roles
for
signaling
a
wide
array
behaviors,
including
cognitive,
homeostatic,
affective
focusing
its
physiological
roles,
potential
pathological
implications.
We
specifically
highlight
how
different
types
linked
distinct
outcomes
discuss
limitations
unanswered
questions
that
remain
be
addressed.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 27, 2025
The
circadian
clock
is
present
in
nearly
all
tissues
(including
glial
cells),
which
play
crucial
roles
brain
functions
and
development.
Circadian
genes
(CCGs)
are
responsible
for
regulating
numerous
cancer-associated
biological
mechanisms,
including
the
regulation
of
cell
cycle
genes,
apoptosis,
proliferation.
A
range
studies
have
already
confirmed
potential
link
between
tumors
CCGs,
Bmal1,
Clock,
Period
1,
2,
3,
Cry1,
Cry2,
retinoid-related
orphan
receptor-α
(ROR-α).
Growing
evidence
regarding
gliomas
glioblastoma
multiforme
(GBM)
indicates
significance
modulation
CCG
cancer
biology.
Various
revealed
how
tumor
cells
can
disrupt
CCGs
to
safeguard
their
survival.
It
has
also
recently
been
demonstrated
case
(especially
GBM)
that
should
be
targeted
development
novel
therapies
or
ameliorate
current
treatments
impair
abolish
growth.
Multiple
pharmacological
modulators
reported
as
effective
tumors,
such
temozolomide,
inhibitors
casein
kinase
1
curcumin,
norepinephrine,
melatonin,
REV-ERB
agonists,
agonists
retinoic
acid-related
receptor,
cryptochrome
protein
stabilizers,
1A-116.
In
this
review,
an
overview
genetics
clock,
pathological
disruptions
discussed.
addition,
interventions
modulate
reviewed.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(11), С. 5116 - 5116
Опубликована: Май 26, 2025
The
circadian
clock
orchestrates
nearly
every
aspect
of
physiology,
aligning
metabolic
processes
with
environmental
cues,
such
as
light
and
food
intake.
While
the
central
pacemaker
in
suprachiasmatic
nucleus
synchronizes
peripheral
clocks
across
key
tissue,
feeding
behavior
emerges
dominant
cue
for
alignment.
This
interaction
reveals
a
crucial
link
between
biology
metabolism.
Disruption
these
processes,
whether
from
shift
work,
irregular
eating
patterns
or
lifestyle
misalignment,
has
been
strongly
associated
disorders,
including
obesity,
insulin
resistance
cardiometabolic
diseases.
Within
field
chrononutrition,
strategies,
time-restricted
(TRF),
have
gained
attention
their
potential
to
restore
alignment
improve
health.
However,
translational
gaps
persist,
most
mechanistic
insights
are
derived
nocturnal
murine
models,
limiting
applicability
diurnal
human
physiology.
Moreover,
studies
confounded
by
interindividual
variability
chronotype,
behavioral
patterns,
dietary
compliance.
review
explores
molecular
underpinnings
zeitgeber
signals
critically
assesses
barriers
implementing
chrononutrition
species.
By
integrating
both
preclinical
clinical
research,
we
aim
refine
circadian-based
interventions
disease
prevention
personalized
nutrition.
