Biomedical & Pharmacology Journal,
Год журнала:
2024,
Номер
17(4), С. 2203 - 2216
Опубликована: Дек. 30, 2024
Sarcopenia
and
malnutrition
can
coexist
in
pediatric
patients
with
neoplasia,
worsening
the
patient's
prognosis.
The
classification
of
primary
secondary
sarcopenia
may
be
helpful
clinical
practice,
as
it
help
timely
initiation
appropriate
tailored
dietary
treatments
to
address
it.
This
review
summarizes
current
state
art
assessing
skeletal
muscle
function
children
adolescents
cancer
discusses
role
nutritional
interventions
management
cancer.
It
highlights
urgent
need
for
comprehensive
support
mitigate
impact
malnutritions
on
both
treatment
outcomes
patients'
well-being.
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 433 - 433
Опубликована: Апрель 2, 2024
Our
study
aimed
to
explore
the
impact
and
mechanism
of
Euonymus
alatus
leaf
extract
on
age-dependent
oxidative
stress,
neuroinflammation,
progressive
memory
impairments
in
aged
mice.
Twenty-four-month-old
mice
received
EA-L3
(300
mg/kg/day)
or
reference
drug,
donepezil
(DPZ,
5
mg/kg/day),
for
6
weeks,
learning
functions
were
detected
using
Passive
Avoidance
Test
(PAT).
As
expected,
cognitive
function
deficits
compared
with
young
mice,
these
significantly
mitigated
by
dietary
treatments
EA-L3.
In
parallel,
it
upregulated
brain-derived
neurotrophic
factor
(BDNF)
subsequently
activated
extracellular-signal-regulated
kinase
(ERK)/cAMP
response
element-binding
(CREB)
signaling
mouse
hippocampus
scopolamine-induced
B35
SH-SY5Y
neuroblastoma
cells.
showed
strong
anti-inflammatory
effects
decreased
NF-κBp65,
cyclooxygenase
2
(COX-2),
tumor
necrosis
alpha
(TNF-α),
increased
interleukin
(IL)-10,
doublecortin
(DCX)
protein
expression
Similar
results
also
confirmed
LPS-induced
BV-2
microglia
cells
upon
treatment
extract.
addition,
notably
dose-dependently
ROS
BV2
after
exposure
LPS.
Taken
together,
might
be
used
as
a
supplement
alleviate
deterioration
hippocampal-based
tasks,
neuroinflammation
elderly
people.
Abstract
Aging
is
an
intricate
process
involving
interactions
among
multiple
factors,
which
one
of
the
main
risks
for
chronic
diseases,
including
Alzheimer's
disease
(AD).
As
a
member
cysteine
protease,
cathepsin
S
(CTSS)
has
been
implicated
in
inflammation
across
various
diseases.
Here,
we
investigated
role
neuronal
CTSS
aging
and
AD
started
by
examining
expression
hippocampus
neurons
mice
identified
significant
increase,
was
negatively
correlated
with
recognition
abilities.
Concurrently,
observed
elevation
concentration
serum
elderly
people.
Transcriptome
fluorescence‐activated
cell
sorting
(FACS)
results
revealed
that
overexpression
aggravated
brain
inflammatory
milieu
microglia
activation
to
M1
pro‐inflammatory
phenotype,
chemokine
C‐X3‐C‐motif
ligand
1
(CX3CL1)—chemokine
receptor
(CX3CR1)
axis
janus
kinase
2
(JAK2)—signal
transducer
activator
transcription
3
(STAT3)
pathway.
CX3CL1
secreted
acts
on
CX3CR1
microglia,
our
first
time
neuron
neuron–microglia
“crosstalk.”
Besides,
elevated
regions
patients,
hippocampus.
Utilizing
selective
inhibitor,
LY3000328,
rescued
AD‐related
pathological
features
APP/PS1
mice.
We
further
noticed
increased
B
(CTSB)
activity,
but
decreased
L
(CTSL)
activity
microglia.
Overall,
provide
evidence
can
be
used
as
biomarker
plays
regulatory
roles
through
modulating
neuroinflammation
process.
Nature Neuroscience,
Год журнала:
2024,
Номер
27(9), С. 1774 - 1782
Опубликована: Авг. 6, 2024
Abstract
Despite
the
well-known
health
benefits
of
physical
activity,
many
people
underexercise;
what
drives
prioritization
exercise
over
alternative
options
is
unclear.
We
developed
a
task
that
enabled
us
to
study
how
mice
freely
and
rapidly
alternate
between
wheel
running
other
voluntary
activities,
such
as
eating
palatable
food.
When
multiple
alternatives
were
available,
chose
spend
substantial
amount
time
without
any
extrinsic
reward
maintained
this
behavior
even
when
food
was
added
an
option.
Causal
manipulations
correlative
analyses
appetitive
consummatory
processes
revealed
preference
for
be
instantiated
by
hypothalamic
hypocretin/orexin
neurons
(HONs).
The
effect
HON
on
strongly
context-dependent,
being
largest
in
scenario
where
both
available.
Overall,
these
data
suggest
activity
enables
eat–run
arbitration
results
choosing
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1590 - 1590
Опубликована: Фев. 13, 2025
As
the
world's
population
continues
to
age,
social
patterns
are
changing,
making
aging
a
notable
public
health
challenge.
With
as
major
risk
factor
for
cognitive
decline,
global
prevalence
of
dementia
is
projected
triple
in
next
25
years.
In
light
growing
body
evidence
involvement
microbiota
and
pathology,
its
role
age-related
decline
should
be
explored.
Therefore,
aim
this
narrative
review
thoroughly
analyze
ways
which
might
affect
process
decline.
Overall,
complex
phenomenon
manifested
at
systemic,
cellular
molecular
levels.
According
recent
studies,
gut
composition
may
influence
changes
through
gut-brain
axis.
One
mechanism
involves
dysbiosis-related
chronic
systemic
inflammation,
leading
blood-brain
barrier
disruption
subsequent
neuroinflammatory
processes.
addition
inflammaging,
induce
oxidative
stress,
another
key
brain
aging.
Finally,
not
only
microbiota,
but
also
colonizing
oral
cavity
associated
with
neurodegenerative
diseases.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 284 - 284
Опубликована: Фев. 20, 2025
Cognitive
aging,
characterized
by
the
gradual
decline
in
cognitive
functions
such
as
memory,
attention,
and
problem-solving,
significantly
impacts
daily
life.
This
is
often
accelerated
neurodegenerative
diseases,
particularly
Alzheimer’s
Disease
(AD)
Parkinson’s
(PD).
AD
marked
accumulation
of
amyloid-beta
plaques
tau
tangles,
whereas
PD
involves
degeneration
dopaminergic
neurons.
Both
conditions
lead
to
severe
impairment,
greatly
diminishing
quality
life
for
affected
individuals.
Recent
advancements
regenerative
medicine
have
highlighted
mesenchymal
stromal
cells
(MSCs)
their
derived
exosomes
promising
therapeutic
options.
MSCs
possess
regenerative,
neuroprotective,
immunomodulatory
properties,
which
can
promote
neurogenesis,
reduce
inflammation,
support
neuronal
health.
Exosomes,
nanosized
vesicles
from
MSCs,
provide
an
efficient
means
delivering
bioactive
molecules
across
blood–brain
barrier,
targeting
underlying
pathologies
PD.
While
these
therapies
hold
great
promise,
challenges
variability
MSC
sources,
optimal
dosing,
effective
delivery
methods
need
be
addressed
clinical
application.
The
development
robust
protocols,
along
with
rigorous
trials,
crucial
validating
safety
efficacy
exosome
therapies.
Future
research
should
focus
on
overcoming
barriers,
optimizing
treatment
strategies,
exploring
integration
lifestyle
interventions.
By
addressing
challenges,
MSC-
exosome-based
could
offer
transformative
solutions
improving
outcomes
enhancing
individuals
aging
diseases.
