Archives of Biochemistry and Biophysics, Год журнала: 2024, Номер unknown, С. 110221 - 110221
Опубликована: Ноя. 1, 2024
Язык: Английский
Pathology - Research and Practice, Год журнала: 2024, Номер 257, С. 155312 - 155312
Опубликована: Апрель 22, 2024
Язык: Английский
Процитировано
3
Free Radical Biology and Medicine, Год журнала: 2024, Номер 224, С. 272 - 286
Опубликована: Авг. 29, 2024
Язык: Английский
Процитировано
3
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 15, 2024
The prevalence of age-related degenerative joint diseases, particularly intervertebral disc degeneration and osteoarthritis, is increasing, thereby posing significant challenges for the elderly population. Mitochondrial dysfunction a critical factor in etiology progression these disorders. Therapeutic interventions that incorporate mitochondrial transplantation exhibit considerable promise by increasing numbers improving their functionality. Existing evidence suggests exogenous therapy improves clinical outcomes patients with diseases. This review elucidates abnormalities associated diseases examines mechanisms intercellular transfer artificial transplantation. Furthermore, therapeutic strategies are synthesized, concept engineered proposed.
Язык: Английский
Процитировано
2
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 4839 - 4854
Опубликована: Июль 30, 2024
Intervertebral disc degeneration (IVDD) is a prevalent chronic condition causing spinal pain and functional impairment. This study investigates the role of extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (hUCMSCs) in regulating IVDD. Using RNA-seq, we analyzed differential expressions lncRNA miRNA nucleus pulposus tissues various mouse groups. We identified key regulatory molecules, MALAT1 miRNA-138-5p, which contribute to Further experiments demonstrated that can up-regulate SLC7A11 expression by competitively binding miR-138-5p, forming MALAT1/miR-138-5p/SLC7A11 coexpression network. elucidates molecular mechanism hUCMSC-derived EVs regulate IVDD could help develop novel therapeutic strategies for treating this condition. Our findings demonstrate hUCMSCs-EVs inhibit ferroptosis cells, thereby improving These results highlight potential ameliorating development IVDD, offering significant scientific clinical implications new treatments.
Язык: Английский
Процитировано
1
Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 25, 2024
Low back pain (LBP) caused by nucleus pulposus degeneration and calcification leads to great economic social burden worldwide. Unexpectedly, no previous studies have demonstrated the association underlying mechanism between tissue formation. Secreted Phosphoprotein 1 (SPP1) exerts crucial functions in bone matrix mineralization calcium deposition. Here, a novel function of SPP1 is reported, namely that it can aggravate cells (NPs) negatively regulating extracellular homeostasis. The degenerated NPs higher potential, which achieved SPP1. Mechanistically, accelerate activating integrin α5β1 (ITGα5/β1), aggravating mitochondrial damage inhibiting mitophagy. SPP1-ITGα5/β1 axis inhibits mitophagy PINK1/PARKIN pathway blockade. In conclusion, activates ITGα5/β1 inhibit mitophagy, accelerates degeneration, induces calcification, thereby leading intervertebral disc (IVDD) identifying potentially unknown relationship IVDD calcification. Important insights are provided into role inducing cell senescence through inhibition may help develop potential new strategies for treatment.
Язык: Английский
Процитировано
1
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Окт. 21, 2024
Background Intervertebral disk degeneration (IVDD) is a complex degenerative skeletal condition, potentially influenced by micronutrients and serum metabolites in its etiology. However, the exact causal relationship between these factors IVDD remains ambiguous. Methods The research employed Two-Sample Mendelian Randomization (2SMR) analysis to thoroughly evaluate 15 (consisting of 7 minerals 8 vitamins) as exposure variables, 1,091 blood metabolites, 309 metabolite ratios intermediary factors, outcome. Additionally, reverse MR mediation were carried out validate reliability results explore underlying mechanism which influence risk regulating metabolites. Results Among examined, vitamin B12 exhibited noteworthy negative correlation with incidence (OR: 0.752, 95% [CI]: 0.573–0.987, p = 0.040), indicating potential reduction increased consumption. Of analyzed, 52 displayed significant associations IVDD, primarily linked amino acid, fatty nucleotide, sphingolipid metabolic pathways. Mediation identified 4-acetaminophen sulfate mediator protective effect against IVDD. Conclusion This study has shown that may reduce are associated Furthermore, it proposes could serve exerts inhibitory effects on
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 181, С. 117505 - 117505
Опубликована: Ноя. 4, 2024
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Phytotherapy Research, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 8, 2024
Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.
Язык: Английский
Процитировано
0