Advanced Neuronal Modulation with Semiconducting Graphitic Carbon Nitride: Insights from In Vitro, In Vivo, and In Silico Studies

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Impaired neuronal functions and cell death within ailments such as neurodegenerative Parkinson's disease pose significant challenges due to their complex pathophysiology limited treatment options. In this landscape, innovative materials with unique physicochemical properties that ameliorate the debilitated are critically required. Neuronal rely on conduction of nerve impulses, a process can be effectively targeted using advanced exhibit conducive essential for modulating neural activity. For semiconductor characteristics, combined well-suited biocompatibility, graphitic carbon nitride (g-C3N4) nanosheets provide promising avenues neurotherapeutic applications. Our multidisciplinary study investigates potential g-C3N4 in promoting differentiation network formation across vitro vivo systems. SH-SY5Y cells exposed demonstrated enhanced neuritic outgrowth over chronic 21-days period, accompanied by an increased intracellular Ca2+ influx, pivotal dopamine biosynthesis, evidenced upregulated expression vesicular monoamine transporter 2 (VMAT2), aromatic l-amino acid decarboxylase (AADC), tyrosine hydroxylase (TH) genes. Utilizing transgenic Caenorhabditis elegans model expressing human α-synuclein, we observed neuroprotective g-C3N4, reduced protein aggregation improved dopaminergic functions. pursuit exploring mechanism g-C3N4-induced stimulation, semiconducting nature came forth, which was further validated theoretical (in silico) models. These models increase chemical material upon application electrical biases. Studying channel inhibition, also phenotypic molecular effects were outcomes stimulation caused presence nanosheets. findings, supported experimental silico studies, suggest modulate behavior through properties, offering therapeutic interventions diseases.

Язык: Английский

P-glycoproteins in anthelmintic safety, efficacy, and resistance

Trends in Parasitology, Год журнала: 2024, Номер 40(10), С. 896 - 913

Опубликована: Авг. 20, 2024

Язык: Английский