The impact of diabetes mellitus on tendon pathology: a review DOI Creative Commons
Jian Xu, Jinbo Wang,

Yuncong Ji

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 5, 2024

Diabetes is one of the most common metabolic diseases worldwide, leading to complications, mortality, and significant healthcare expenditures, which impose a substantial social financial burden globally. A diabetic environment can induce changes, negatively affecting tendon homeostasis, alterations in biomechanical properties histopathology. Numerous studies have investigated mechanisms through diabetes exerts pathological effects on tendons, including increased free radical production, oxidative stress, inflammatory responses, deposition advanced glycation end products (AGEs), microvascular changes. These changes damages structure, biomechanics, repair processes. The proliferation stem cells decreases, apoptosis increases, abnormal differentiation, along with expression myofibroblasts, ultimately lead insufficient repair, fibrosis, remodeling. Although researches unveiling tendinopathy, fibrosis or contracture, injury healing are growing, systematic understanding still lacking. Therefore, this review summarizes current research status provides comprehensive overview, offering theoretical guidance for future in-depth exploration impact tendons development treatments diabetes-related diseases.

Язык: Английский

The impact of diabetes mellitus on tendon pathology: a review DOI Creative Commons
Jian Xu, Jinbo Wang,

Yuncong Ji

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 5, 2024

Diabetes is one of the most common metabolic diseases worldwide, leading to complications, mortality, and significant healthcare expenditures, which impose a substantial social financial burden globally. A diabetic environment can induce changes, negatively affecting tendon homeostasis, alterations in biomechanical properties histopathology. Numerous studies have investigated mechanisms through diabetes exerts pathological effects on tendons, including increased free radical production, oxidative stress, inflammatory responses, deposition advanced glycation end products (AGEs), microvascular changes. These changes damages structure, biomechanics, repair processes. The proliferation stem cells decreases, apoptosis increases, abnormal differentiation, along with expression myofibroblasts, ultimately lead insufficient repair, fibrosis, remodeling. Although researches unveiling tendinopathy, fibrosis or contracture, injury healing are growing, systematic understanding still lacking. Therefore, this review summarizes current research status provides comprehensive overview, offering theoretical guidance for future in-depth exploration impact tendons development treatments diabetes-related diseases.

Язык: Английский

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