Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications

Biomolecules, Год журнала: 2025, Номер 15(1), С. 149 - 149

Опубликована: Янв. 19, 2025

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder marked by the progressive degeneration of midbrain dopaminergic neurons and resultant locomotor dysfunction. Despite over two centuries recognition as chronic disease, exact pathogenesis PD remains elusive. The onset progression involve multiple complex pathological processes, with dysfunctional autophagy elevated oxidative stress serving critical contributors. Notably, emerging research has underscored interplay between in pathogenesis. Given limited efficacy therapies targeting either dysfunction or stress, it crucial to elucidate intricate mechanisms governing their develop more effective therapeutics. This review overviews role nuclear factor erythroid 2-related 2 (Nrf2), pivotal transcriptional regulator orchestrating cellular defense against these processes. By elucidating key processes PD, this will deepen our comprehensive understanding multifaceted underlying may uncover potential strategies for its prevention treatment.

Язык: Английский

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Intersecting molecular pathways in Synucleinopathies and Amyloidogenesis: Exploring shared mechanisms and therapeutic potential

Brain Research, Год журнала: 2025, Номер unknown, С. 149568 - 149568

Опубликована: Март 1, 2025

Язык: Английский

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ZKSCAN3 affects the autophagy‑lysosome pathway through TFEB in Parkinson's disease

Biomedical Reports, Год журнала: 2025, Номер 22(4), С. 1 - 10

Опубликована: Фев. 25, 2025

The present study aimed to explore the effects of zinc finger with KRAB and SCAN domains 3 (ZKSCAN3)/transcription factor EB (TFEB) on autophagy‑lysosome pathway in Parkinson's disease (PD). SH‑SY5Y cells were treated 6‑hydroxydopamine establish a PD cell model. A ZKSCAN3 overexpression vector short interfering (si)RNAs also constructed. TFEB was transfected into siRNA vector. Reverse transcription‑quantitative western blotting performed detect expression levels Beclin‑1, LC3II/I, α‑synuclein lysosomal‑associated membrane protein 1 (Lamp‑1). Lysosomes labelled LysoTracker Red morphological changes lysosomes detected by using laser confocal scanning microscopy. Transmission electron microscopy used observe autophagosomes lysosomes. Compared those normal group, model group presented decreases LC3B, ZKSCAN3, TFEB, Beclin‑1 Lamp‑1 mRNA increases LC3A, LC3II/I levels. resulted decrease LC3I mRNA, LC3 II/I levels, as well an increase LC3II interference LC3A protein, LC3B α‑synuclein. reversed ZKSCAN3. results lysosome detection revealed that, compared that fluorescence intensity lower. greater than empty group. number In conclusion, affected occurrence development through TFEB‑mediated pathway.

Язык: Английский

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An Arginine-rich motif of the HIV-1 TAT protein promotes E. coli cellular entry and DNA delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106864 - 106864

Опубликована: Март 1, 2025

Язык: Английский

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Alpha-Synuclein drives NURR1 and NLRP3 Inflammasome dysregulation in Parkinson's disease: From pathogenesis to potential therapeutic strategies

International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114692 - 114692

Опубликована: Апрель 22, 2025

Язык: Английский

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