International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12862 - 12862
Опубликована: Ноя. 29, 2024
Advances in three-dimensional culture technologies have facilitated the development of synthetic embryo models, such as blastoids, through co-culturing diverse stem cell types. These vitro models enable precise investigation developmental processes, including gastrulation, neurulation, and lineage specification, thereby advancing our understanding early embryogenesis. By providing controllable, ethically viable platforms, they help circumvent limitations vivo mammalian studies contribute to developing regenerative medicine strategies. Nonetheless, ethical challenges, particularly regarding human applications, persist. Comparative across various species—such mice, humans, non-human primates, ungulates, like pigs cattle—offer crucial insights into both species-specific conserved mechanisms. In this review, we outline differences embryonic discuss recent advancements models. Specifically, focus on latest research involving cattle, provide a comprehensive overview improvements technology. biology, improve model efficiency, guide new
Язык: Английский