Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the Keap1/Nrf2/HO-1 pathway DOI Creative Commons
Jingzhi Su, Ying Zhang, Xuan Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 30, 2025

Background Diabetic nephropathy (DN) is a serious complication of diabetes and one the leading causes end-stage renal disease. Huangkui capsule (HKC), traditional Chinese patent medicine, widely used in clinical practice for treatment chronic glomerulonephritis. However, therapeutic effects underlying mechanisms HKC DN remain poorly understood. Methods was induced db/db mice, which were randomly divided into DN, HKC-L, HKC-H IRB groups, db/m mice served as Control group. Biochemical indices blood urine samples from measured, HE staining, Masson staining PAS to verify anti-DN effect HKC. The levels ROS expression Nrf 2 pathway-related proteins mRNAs detected. Metabonomic analysis investigate role tryptophan metabolism regulation by HK-2 cells establish model high-glucose (HG) injury vitro , given supplementary verification. Sarpogrelate hydrochloride (SH) combined with HKC, 5-HT 2A R inhibitor, pathway an model. Results Treatment significantly inhibited increase glucose Urinary albumin/creatinine ratio (UACR), improved kidney signs reduced level oxidative stress through Keap1/ /HO-1 pathway. revealed that involved process improves can regulate improve regulation. also injuries HG cell . SH administration inhibiting could inhibit synthesis HG. Conclusion Our study demonstrate regulating Keap1/Nrf pathway, provides new insight use DN.

Язык: Английский

Gut microbiota-derived metabolites: Potential targets for cardiorenal syndrome DOI Creative Commons

Yu-Chen Lai,

Yujie Zhu,

Xihui Zhang

и другие.

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107672 - 107672

Опубликована: Фев. 1, 2025

The characteristic of cardiorenal syndrome (CRS) is simultaneous damage to both the heart and kidneys. CRS has caused a heavy burden mortality incidence rates worldwide. regulation host microbiota metabolism that triggers kidney an emerging research field promotes new perspective on cardiovascular risk. We summarize current studies from bench bedside gut microbiota-derived metabolites better understand in context metabolites. focused involvement pathophysiology CRS, including lipid cholesterol disorders, coagulation abnormalities platelet aggregation, oxidative stress, endothelial dysfunction, inflammation, mitochondrial energy vascular calcification renal fibrosis, as well therapeutic approaches targeting which provides innovative treatment approach for improve patient prognosis overall quality life.

Язык: Английский

Процитировано

0
Natural products in traditional Chinese medicine for renal fibrosis: a comprehensive review DOI Creative Commons
Qianqian Zhao, Meihua Jin, Qiang Zhao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Renal fibrosis represents the terminal pathological manifestation of most chronic kidney diseases, driving progressive loss renal function. Natural products have emerged as promising therapeutic agents for preventing and ameliorating due to their multi-target efficacy favorable safety profiles. In this review, we conducted a comprehensive literature search on PubMed using keywords “natural product” “renal fibrosis” from 2004 2025, identifying 704 relevant articles. We systematically categorize discuss biological effects key natural formulations with antifibrotic potential, focusing five major classes: glycosides, flavonoids, phenolic compounds, anthraquinones, terpenoids. Representative compounds each category are highlighted mechanisms action, including modulation oxidative stress, inflammation, autophagy, signaling pathways. This review aims provide theoretical foundation development product-based therapies combat fibrosis, offering insights into potential future research directions.

Язык: Английский

Процитировано

0
Perturbed gut microbiota and serum metabolites are associated with progressive renal fibrosis DOI Creative Commons

Run-Xi Wang,

Hong-Bing Zhou, Jin Gao

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 28, 2025

Introduction The intricate pathogenesis of renal fibrosis necessitates identifying biomarkers at various stages to facilitate targeted therapeutic interventions, which would enhance patient survival rates and significantly improve prognosis. Methods We investigated the changes in gut microbiota serum metabolites during early, middle, late rats using 16S rDNA sequencing UPLC-QTOF/MS-based metabolomics. Results identified 5, 21, 14 potential microbial markers 19, 23, 31 metabolic MOD1, MOD2, MOD4 groups, respectively. Bifidobacterium was as a shared marker between MOD1 MOD2 groups; Prevotellaceae_NK3B31_group Bacteroides were groups. pathways arachidonic acid metabolism retinol found play significant role modulation 1, 2, 4 weeks. Notably, 8,9-EET 5(S)-HPETE within these emerged critical determinants influencing fibrosis. Discussion Our findings demonstrated that severity is associated with dysbiosis alterations metabolites.

Язык: Английский

Процитировано

0
Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the Keap1/Nrf2/HO-1 pathway DOI Creative Commons
Jingzhi Su, Ying Zhang, Xuan Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 30, 2025

Background Diabetic nephropathy (DN) is a serious complication of diabetes and one the leading causes end-stage renal disease. Huangkui capsule (HKC), traditional Chinese patent medicine, widely used in clinical practice for treatment chronic glomerulonephritis. However, therapeutic effects underlying mechanisms HKC DN remain poorly understood. Methods was induced db/db mice, which were randomly divided into DN, HKC-L, HKC-H IRB groups, db/m mice served as Control group. Biochemical indices blood urine samples from measured, HE staining, Masson staining PAS to verify anti-DN effect HKC. The levels ROS expression Nrf 2 pathway-related proteins mRNAs detected. Metabonomic analysis investigate role tryptophan metabolism regulation by HK-2 cells establish model high-glucose (HG) injury vitro , given supplementary verification. Sarpogrelate hydrochloride (SH) combined with HKC, 5-HT 2A R inhibitor, pathway an model. Results Treatment significantly inhibited increase glucose Urinary albumin/creatinine ratio (UACR), improved kidney signs reduced level oxidative stress through Keap1/ /HO-1 pathway. revealed that involved process improves can regulate improve regulation. also injuries HG cell . SH administration inhibiting could inhibit synthesis HG. Conclusion Our study demonstrate regulating Keap1/Nrf pathway, provides new insight use DN.

Язык: Английский

Процитировано

0