Phytomedicine, Год журнала: 2025, Номер unknown, С. 156915 - 156915
Опубликована: Июнь 1, 2025
Язык: Английский
Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107672 - 107672
Опубликована: Фев. 1, 2025
The characteristic of cardiorenal syndrome (CRS) is simultaneous damage to both the heart and kidneys. CRS has caused a heavy burden mortality incidence rates worldwide. regulation host microbiota metabolism that triggers kidney an emerging research field promotes new perspective on cardiovascular risk. We summarize current studies from bench bedside gut microbiota-derived metabolites better understand in context metabolites. focused involvement pathophysiology CRS, including lipid cholesterol disorders, coagulation abnormalities platelet aggregation, oxidative stress, endothelial dysfunction, inflammation, mitochondrial energy vascular calcification renal fibrosis, as well therapeutic approaches targeting which provides innovative treatment approach for improve patient prognosis overall quality life.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Апрель 16, 2025
Renal fibrosis represents the terminal pathological manifestation of most chronic kidney diseases, driving progressive loss renal function. Natural products have emerged as promising therapeutic agents for preventing and ameliorating due to their multi-target efficacy favorable safety profiles. In this review, we conducted a comprehensive literature search on PubMed using keywords "natural product" "renal fibrosis" from 2004 2025, identifying 704 relevant articles. We systematically categorize discuss biological effects key natural formulations with antifibrotic potential, focusing five major classes: glycosides, flavonoids, phenolic compounds, anthraquinones, terpenoids. Representative compounds each category are highlighted mechanisms action, including modulation oxidative stress, inflammation, autophagy, signaling pathways. This review aims provide theoretical foundation development product-based therapies combat fibrosis, offering insights into potential future research directions.
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Апрель 28, 2025
The intricate pathogenesis of renal fibrosis necessitates identifying biomarkers at various stages to facilitate targeted therapeutic interventions, which would enhance patient survival rates and significantly improve prognosis. We investigated the changes in gut microbiota serum metabolites during early, middle, late rats using 16S rDNA sequencing UPLC-QTOF/MS-based metabolomics. identified 5, 21, 14 potential microbial markers 19, 23, 31 metabolic MOD1, MOD2, MOD4 groups, respectively. Bifidobacterium was as a shared marker between MOD1 MOD2 groups; Prevotellaceae_NK3B31_group Bacteroides were groups. pathways arachidonic acid metabolism retinol found play significant role modulation 1, 2, 4 weeks. Notably, 8,9-EET 5(S)-HPETE within these emerged critical determinants influencing fibrosis. Our findings demonstrated that severity is associated with dysbiosis alterations metabolites.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Апрель 30, 2025
Diabetic nephropathy (DN) is a serious complication of diabetes and one the leading causes end-stage renal disease. Huangkui capsule (HKC), traditional Chinese patent medicine, widely used in clinical practice for treatment chronic glomerulonephritis. However, therapeutic effects underlying mechanisms HKC DN remain poorly understood. was induced db/db mice, which were randomly divided into DN, HKC-L, HKC-H IRB groups, db/m mice served as Control group. Biochemical indices blood urine samples from measured, HE staining, Masson staining PAS to verify anti-DN effect HKC. The levels ROS expression Nrf2 pathway-related proteins mRNAs detected. Metabonomic analysis investigate role tryptophan metabolism regulation by HK-2 cells establish model high-glucose (HG) injury vitro, given supplementary verification. Sarpogrelate hydrochloride (SH) combined with HKC, 5-HT2AR inhibitor, 5-HT pathway an vitro model. Treatment significantly inhibited increase glucose Urinary albumin/creatinine ratio (UACR), improved kidney signs reduced level oxidative stress through Keap1/ Nrf2/HO-1 pathway. revealed that involved process improves can regulate improve regulation. also injuries HG cell vitro. SH administration inhibiting could inhibit synthesis HG. Our study demonstrate regulating Keap1/Nrf2/HO-1 pathway, provides new insight use DN.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Май 6, 2025
Chronic kidney disease (CKD) is a global health issue, affecting approximately 10% of the population. Hypoalbuminemia, common complication in advanced CKD, associated with poor prognosis. This study aimed to investigate association between microbiota-friendly dietary scoring system (Dietary Index for Gut Microbiota, DI-GM) and serum albumin levels patients CKD. We utilized cross-sectional cohort from NHANES 2007-2018, which included 2,947 CKD patients. Multivariable logistic regression restricted cubic spline models were applied analyze relationship DI-GM scores albumin. Higher significantly increased (β = 0.18 g/L, 95% CI: 0.07-0.28, p 0.002). Furthermore, each 1-point increase score was linked 15% reduction odds hypoalbuminemia (OR: 0.85, 0.74-0.97, 0.014). The findings suggest that high diet may have beneficial effects managing by modulating gut microbiota composition reducing inflammation. pattern could be promising intervention improving clinical outcomes patients, especially those at risk malnutrition
Язык: Английский
Процитировано
0
Veterinary Sciences, Год журнала: 2025, Номер 12(6), С. 541 - 541
Опубликована: Июнь 3, 2025
Faecal microbiota transplantation (FMT) has emerged as a transformative therapy in human medicine, particularly for managing recurrent Clostridioides difficile infections and other gastrointestinal (GI) disorders. Beyond the GI tract, FMT shown potential addressing extraintestinal conditions people, including metabolic, immune-mediated, dermatological, neurological, infectious diseases. Research people highlighted its efficacy decolonising multidrug-resistant organisms infection, mitigating autoimmune diseases, improving outcomes metabolic disorders such obesity diabetes. Furthermore, also been linked to enhanced responses immunotherapy cancer improved management of hepatic renal conditions. These findings underscore intricate connections between gut microbiome systemic health, opening novel therapeutic avenues. In veterinary while demonstrated benefits disorders, application diseases remains largely unexplored. Emerging evidence suggests that atopic dermatitis, chronic kidney disease, immune-mediated behavioural companion animals could benefit from microbiome-targeted therapies. However, significant gaps knowledge persist, regarding long-term safety applications. This review synthesises medicine assess their relevance applications future research.
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2025, Номер unknown, С. 156915 - 156915
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0