The Synergy of Microwave‐Irradiation and Water Surface: A Fast Access to C‐2 Functionalized Indolizines Via Baylis–Hillman Reaction

Chemistry - An Asian Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract Herein, we report a sustainable, rapid, and cost‐effective methodology for the synthesis of 2‐functionalized indolizines from pyridine‐2‐carboxaldehydes by coupling with α,β ‐unsaturated compounds via Baylis–Hillman pathway followed cyclization in one‐pot using DBU as organocatalyst “on‐water” under microwave irradiation. The water medium played pivotal role achieving quick conversion to products just 1 min good high yields (up 78%). method is further validated on several 2‐acylpyridines; however, these cases longer time h) was required complete due steric bulk at reaction center 1,2‐functionalized are obtained similar 74%). substituent variation pyridine show negligible electronic effect diverse functional group tolerance observed. Furthermore, scalability studied gram‐scale representative examples, which afford comparable that small‐scale reactions. present tick multiple sustainability matrices like metal‐free synthesis, medium, cost‐effectiveness, low E‐factor.

Язык: Английский

Synthesis and Biological Evaluation of 1,3,4-oxadiazole ring incorporated (pyrimidin-5-yl)indolizine as Anticancer Agents

Chemical Data Collections, Год журнала: 2025, Номер unknown, С. 101190 - 101190

Опубликована: Май 1, 2025

Язык: Английский

Synthesis of indolizines via Pd-catalyzed selective ring recasting of oxazolidines with deesterification of methyl acrylates

Sustainable Chemistry and Pharmacy, Год журнала: 2025, Номер 46, С. 102059 - 102059

Опубликована: Июнь 5, 2025

Язык: Английский