Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review DOI Creative Commons

Hussam Elddin Nabeih Khasawneh,

Ali Abdulrazzaq Abdulhussein Alrikabi,

Amran M. AL-Erjan

и другие.

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102271 - 102271

Опубликована: Апрель 1, 2025

Язык: Английский

Design, synthesis and biological evaluation of non-glucosidal based 1,3,4-thiadiazoles as SGLT-2 inhibitors DOI

Shivani Sharma,

Shubham Kumar, Jeena Gupta

и другие.

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 15

Опубликована: Фев. 11, 2025

Type-2 diabetes mellitus (T2DM) is a major metabolic disorder needing insulin-independent treatments; this study developed Schiff base 1,3,4-thiadiazole as Sodium Glucose Co-transporters 2 (SGLT2) inhibitors. The target compounds were synthesized followed by docking studies, in vitro and vivo analysis. In assay revealed SSS 6 exhibited high SGLT2 inhibition activity i.e. 78.57% ± 2.8 74.60% 1.12 compared to dapagliflozin (93.65% 4.48) at same dosage enzyme assays. results reveals that significantly improved excretion of urinary glucose (854 46.51 mg/body weight) (775 32.68 weight. decreased blood levels (137 4.89 mg/dL 183 15.07 mg/dL) relative (158 15.9 mg/dL). Compounds emerge potential candidates for further investigation inhibitors treating T2DM.

Язык: Английский

Процитировано

0

Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review DOI Creative Commons

Hussam Elddin Nabeih Khasawneh,

Ali Abdulrazzaq Abdulhussein Alrikabi,

Amran M. AL-Erjan

и другие.

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102271 - 102271

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0