Chronopharmacology in cancer treatment: Optimizing drug timing for improved efficacy and reduced toxicity

Open Access Research Journal of Biology and Pharmacy, Год журнала: 2024, Номер 10(2), С. 001 - 012

Опубликована: Март 12, 2024

Cancer treatment has seen remarkable advancements in recent years, but the accompanying side effects often diminish patient's quality of life. To address this, field chronopharmacology emerged, aiming to optimize cancer by aligning it with circadian rhythms. This article explores intricate relationship between clock and susceptibility, role genes tumor suppression, potential benefits chronopharmacological approaches chemotherapy targeted therapies. Moreover, discusses how chronobiological insights can be applied palliative care hormonal therapies, a patient-centered approach tailor treatments individual The regulatory ethical considerations surrounding are also examined. Ultimately, offers promise more personalized effective treatments, enhancing patient well-being outcomes battle against cancer.

Язык: Английский

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Electrochemically Enhanced Delivery of Pemetrexed from Electroactive Hydrogels

Polymers, Год журнала: 2022, Номер 14(22), С. 4953 - 4953

Опубликована: Ноя. 16, 2022

Electroactive hydrogels based on derivatives of polyethyleneglycol (PEG), chitosan and polypyrrole were prepared via a combination photopolymerization oxidative chemical polymerization, optionally doped with anions (e.g., lignin, drugs, etc.). The products analyzed variety techniques, including: FT-IR, UV-Vis, 1H NMR (solution state), 13C (solid XRD, TGA, SEM, swelling ratios rheology. conductive gels swell ca. 8 times less than the non-conductive due to presence interpenetrating network (IPN) lignin. A rheological study showed that are soft (G' 0.35 kPa, G″ 0.02 kPa) properties analogous brain tissue, whereas significantly stronger 30 19 breast tissue IPN potential these biomaterials be used for biomedical applications was validated in vitro by cell culture studies (assessing adhesion proliferation fibroblasts) drug delivery (electrochemically loading FDA-approved chemotherapeutic pemetrexed measuring passive stimulated release); indeed, application electrical stimulus enhanced release PEM from 10-15% relative control experiment each stimulation over short period duration applied electrochemotherapy. It is foreseeable such materials could integrated electrochemotherapeutic medical devices, e.g., electrode arrays or plates currently clinic.

Язык: Английский

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Circadian rhythms and inflammatory diseases of the liver and gut

Liver Research, Год журнала: 2023, Номер unknown

Опубликована: Авг. 1, 2023

Circadian rhythms play a central role in maintaining metabolic homeostasis and orchestrating inter-organ crosstalk. Research evidence indicates that disruption to rhythms, which occurs through shift work, chronic sleep disruption, molecular clock polymorphisms, or the consumption of alcohol high-fat diets, can influence inflammatory status disrupt timing between brain periphery body external environment. Within liver gut, circadian direct glucose lipid homeostasis, bile acid xenobiotic metabolism, nutrient absorption, making these systems particularly susceptible effects disrupted rhythms. In this review, impacts will be discussed with emphasis on conditions affecting potential for chronotherapy explored.

Язык: Английский

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Joining Forces: The Combined Application of Therapeutic Viruses and Nanomaterials in Cancer Therapy

Molecules, Год журнала: 2023, Номер 28(22), С. 7679 - 7679

Опубликована: Ноя. 20, 2023

Cancer, on a global scale, presents monumental challenge to our healthcare systems, posing significant threat human health. Despite the considerable progress we have made in diagnosis and treatment of cancer, realizing precision cancer therapy, reducing side effects, enhancing efficacy remain daunting tasks. Fortunately, emergence therapeutic viruses nanomaterials provides new possibilities for tackling these issues. Therapeutic possess ability accurately locate attack tumor cells, while serve as efficient drug carriers, delivering medication precisely tissues. The synergy two elements has led novel approach treatment—the combination nanomaterials. This advantageous overcome limitations associated with effects oncolytic insufficient tumoricidal capacity nanomedicines, enabling more effectively breach tumor’s immune barrier. It focuses lesion site even allows real-time monitoring distribution release, achieving synergistic effect. article comprehensively explores application treatment, dissecting their working mechanisms, integrating latest scientific advancements predict future development trends. approach, which combines viral therapy nanomaterials, represents an innovative effective strategy, offering perspectives field therapy.

Язык: Английский

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The Influence of Circadian Rhythm on Cancer Cells Targeting and Transfection Efficiency of a Polycation-Drug/Gene Delivery Vector

Polymers, Год журнала: 2022, Номер 14(4), С. 681 - 681

Опубликована: Фев. 10, 2022

The conception of novel anticancer delivery systems and the combination chronobiology with nanotechnology may provide a powerful tool to optimize cancer therapy. In this work, polyethylenimine (PEI) has been used complex p53 encoded plasmid DNA (pDNA), drug methotrexate (MTX) also loaded into vectors. To investigate influence circadian clock on drug/gene efficiency, HeLa, C33A fibroblast cells have transfected developed PEI/pDNA/MTX vectors at six different time points. Phenomena as cellular uptake/internalization, protein production evaluated. cell-associated MTX fluorescence monitored, levels quantified. HeLa cells, significant were found for T8 T12. For these points, high amount was Confocal microscopy images showed successful cell's uptake particles, T8. comparison, poor in fibroblasts; nevertheless, results indicated rhythmicity. Data demonstrate rhythm both cancer-cells targeting ability transfection performance carriers seemed optimum delivery. This report adds great contribution field chronobiology, highlighting relationship between nanodelivery systems, charting path further research a, yet, poorly explored but promising topic.

Язык: Английский

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Effect of Circadian Rhythm Modulated Blood Flow on Nanoparticle based Targeted Drug Delivery in VirtualIn VivoArterial Geometries

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

Abstract Delivery of drug using nanocarriers tethered with vasculature-targeting epitopes aims to maximize the therapeutic efficacy while minimizing side effects. Circadian rhythm which is governed by central nervous system has implications for targeted delivery due sleep-wake cycle changes in blood flow dynamics. This paper presents an advanced fluid dynamics modeling method that based on viscous incompressible shear-rate (blood) coupled advection-diffusion equation simulate formation concentration gradients stream and buildup at site. The equipped experimentally calibrated nanoparticle-endothelial cell adhesion model employs Robin boundary conditions describe nanoparticle retention probability adhesion, a friction accounting surface roughness endothelial layer, dispersion Taylor-Aris expression effective diffusion layer. computational first validated then tested engineered bifurcating arterial systems where impedance are applied outflow account downstream resistance each outlet. It virtual geometric vivo tree developed through MRI-based image processing techniques. These simulations highlight potential transport, multiple sites models. provides platform exploring circadian modulated experimentation. Statement Significance A novel integration nanoparticle-based framework dependent presented. comprised unique combination mechanics-based model, asperity endothelium roughness, stochastic model. Simulations MRI carotid artery showcase effects vessel geometry Vessel target site location impact adhesion; curved regions favor local accumulation drug. also shown aligning administration sleep can enhance processes.

Язык: Английский

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In vitro and in vivo evaluation of anti-tumorigenesis potential of nano silver for gastric cancer cells

Journal of Molecular Histology, Год журнала: 2024, Номер 56(1)

Опубликована: Ноя. 29, 2024

Язык: Английский

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Radiotherapy of the Hepatocellular Carcinoma in Mice Has a Time-Of-Day-Dependent Impact on the Mouse Hippocampus

Cells, Год журнала: 2022, Номер 12(1), С. 61 - 61

Опубликована: Дек. 23, 2022

Chronic liver diseases including hepatocellular carcinoma (HCC) create a state of chronic inflammation that affects the brain via liver–brain axis leading to an alteration neurotransmission and cognition. However, little is known about effects HCC on hippocampus, key region for learning memory. Moreover, radiotherapy used treat has severe side impair patients’ life quality. Thus, designing optimal strategies, such as chronotherapy, enhance efficacy reduce treatment critically important. We addressed timed administration in mice expression pro-inflammatory cytokines, clock genes, markers glial activation, oxidative stress, neuronal activity proliferation hippocampal neurogenic niche. Our data showed induced upregulation genes encoding altered gene expressions reduced hippocampus. Radiotherapy, particular when applied during light/inactive phase enhanced all these addition increased decreased levels phospho(p)-ERK. results suggested interaction circadian molecular clockwork brain’s innate immune system players crosstalk most profound alterations

Язык: Английский

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Chronobiology and Nanotechnology for Personalized Cancer Therapy

Cancer Nanotechnology, Год журнала: 2022, Номер unknown, С. 205 - 227

Опубликована: Дек. 13, 2022

As a consequence of Earth's rotation in its axis, most organisms this planet are subjected to 24-hour variation light and temperature. A diverse range species developed an internal timekeeping system that allows the better adapt even anticipate those daily variations. This is called biological clock subject study chronobiology. At molecular level, based on autoregulatory transcription-translation feedback loop comprised by genes/proteins present almost every tissue mammals regulate several physiological processes. Over past decades, link between circadian cancer development was established. Moreover, it known, clinical trials, some anticancer medications function when taken at specific time day. concept inclusion therapy, chronotherapy, has been proven improve tolerability antitumor efficacy drugs. Likewise, research nanotechnology also proved be valuable tool provide innovative approaches for enhanced treatment outcomes, as offers means selectively target cells deliver safer effective therapy. The long dream medicine relies implementation precise, personalized therapy healthcare network. Personalized faces challenge common not being big part population, increasing costs term. In chapter, we discuss how chronotherapy could have impact treatment, coordinating drug delivery administration with individual's rhythm.

Язык: Английский

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Different levels of circadian (de)synchrony ­– where does it hurt?

F1000Research, Год журнала: 2023, Номер 11, С. 1323 - 1323

Опубликована: Апрель 3, 2023

A network of cellular timers ensures the maintenance homeostasis by temporal modulation physiological processes across day. These so-called circadian clocks are synchronized to geophysical time external cues (or zeitgebers). In modern societies, natural environmental cycles disrupted artificial lighting, around-the-clock availability food or shift work. Such contradictory zeitgeber input promotes chronodisruption, i.e., perturbation internal circadian rhythms, resulting in adverse health outcomes. While this phenomenon is well described, it still poorly understood at which level organization perturbed rhythms impact on and wellbeing. review, we discuss different levels chronodisruption what known about their effects. We summarize results phase coherence between vs. misalignment tissue clocks amongst each other, i.e., desynchrony. Last, incoherence can also occur itself. Here, alterations coordination emerge same clock genes within single cell. A better understanding mechanisms its effects physiology will help find effective tools prevent treat disorders arising from modern-day chronodisruptive environments.

Язык: Английский

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