PLoS Medicine,
Год журнала:
2023,
Номер
20(1), С. e1004173 - e1004173
Опубликована: Янв. 30, 2023
Background
The
prevalence
of
type
2
diabetes
has
increased
in
both
young
and
old
people.
We
examined
age-specific
associations
population
attributable
fractions
(PAFs)
risk
factors
for
all-cause
cause-specific
mortality
people
with
diabetes.
Methods
findings
analysed
data
from
360,202
Chinese
who
participated
a
territory-wide
complication
screening
programme
Hong
Kong
between
January
2000
December
2019.
compared
the
hazard
ratios
PAFs
eight
factors,
including
three
major
comorbidities
(cardiovascular
disease
[CVD],
chronic
kidney
[CKD],
all-site
cancer)
five
modifiable
(suboptimal
HbA1c,
suboptimal
blood
pressure,
low-density
lipoprotein
cholesterol,
smoking,
weight),
across
four
age
groups
(18
to
54,
55
64,
65
74,
≥75
years).
During
median
6.0
years
follow-up,
44,396
died,
cancer,
CVD,
pneumonia
being
leading
causes
death.
Despite
higher
absolute
older
(crude
rate:
59.7
versus
596.2
per
10,000
person-years
aged
18
54
those
years),
relative
associated
most
was
younger
than
people,
after
mutually
adjusting
other
potential
confounders
sex,
duration,
lipid
profile,
medication
use.
explained
larger
proportion
events
youngest
(PAF:
51.6%,
95%
confidence
interval
[CI]
[39.1%,
64.0%],
p
<
0.001)
oldest
35.3%,
CI
[27.2%,
43.4%],
group.
Suboptimal
pressure
16.9%,
[14.7%,
19.1%],
factor
group,
while
CKD
15.2%,
[14.0%,
16.4%],
CVD
9.2%,
[8.3%,
10.1%],
were
analysis
restricted
Chinese,
which
might
affect
generalisability
global
differences
profiles.
Furthermore,
estimated
under
assumption
causal
relationship
mortality.
However,
reliable
causality
difficult
establish
observational
study.
Conclusions
Major
greater
their
burden
varied
substantially
by
age.
These
highlight
importance
early
control
could
reduce
premature
prevent
onset
later
related
at
ages.
Frontiers in Public Health,
Год журнала:
2023,
Номер
11
Опубликована: Окт. 13, 2023
Aging
is
a
progressive
and
irreversible
pathophysiological
process
that
manifests
as
the
decline
in
tissue
cellular
functions,
along
with
significant
increase
risk
of
various
aging-related
diseases,
including
metabolic
diseases.
While
advances
modern
medicine
have
significantly
promoted
human
health
extended
lifespan,
diseases
such
obesity
type
2
diabetes
among
older
adults
pose
major
challenge
to
global
public
societies
age.
Therefore,
understanding
complex
interaction
between
factors
crucial
for
promoting
well-being
healthy
aging.
This
review
article
explores
environmental
behavioral
associated
their
impact
on
The
environment,
an
obesogenic
environment
exposure
toxins,
strongly
correlated
rising
prevalence
its
comorbidities.
Behavioral
factors,
diet,
physical
activity,
smoking,
alcohol
consumption,
sleep
patterns,
influence
throughout
Public
interventions
targeting
modifiable
can
effectively
promote
healthier
lifestyles
prevent
Collaboration
government
agencies,
healthcare
providers
community
organizations
essential
implementing
these
creating
supportive
environments
foster
Antioxidants,
Год журнала:
2023,
Номер
12(1), С. 123 - 123
Опубликована: Янв. 4, 2023
The
global
prevalence
of
diabetes
continues
to
increase
partly
due
rapid
urbanization
and
an
in
the
aging
population.
Consequently,
this
is
associated
with
a
parallel
diabetic
vascular
complications
which
significantly
worsen
burden
diabetes.
For
these
complications,
there
still
unmet
need
for
safe
effective
alternative/adjuvant
therapeutic
interventions.
There
also
increasing
urge
options
come
from
natural
products
such
as
plants.
Hyperglycemia-induced
oxidative
stress
central
development
complications.
Furthermore,
stress-induced
inflammation
insulin
resistance
are
endothelial
damage
progression
Human
animal
studies
have
shown
that
polyphenols
could
reduce
stress,
hyperglycemia,
prevent
including
retinopathy,
nephropathy,
peripheral
neuropathy.
Part
effects
attributed
their
modulatory
effect
on
endogenous
antioxidant
systems.
This
review
attempts
summarize
established
systems
literature.
Moreover,
potential
strategies
harnessing
benefits
discussed.
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 23, 2025
Objective
To
produce
estimates
of
the
global
burden
type
2
diabetes
mellitus
(T2DM)
caused
by
high
body
mass
index
(high
BMI)
and
its
impact
for
2021
projections
2045.
Methods
We
downloaded
data
from
Global
Burden
Disease
Study
2021(GBD
2021)
to
estimate
disease
T2DM
BMI.
Secondary
analyses
were
performed
year,
age,
gender,
region,
socio-demographic
(SDI).
Results
Globally,
all-ages
number
T2DM-related
deaths
has
increased
significantly
238.1
thousand
723.7
thousand,
representing
a
203.9%
increase
since
1990.
And
T2DM-raleted
DALYs
raised
10.4
million
39.3
million,
276.7%
The
was
expected
continue
1296.7
2045
deaths,
85.5
DALYs.
curves
showed
an
intersection
different
genders
around
age
60,
beyond
which
women
exhibit
higher
burden,
compared
men.
BMI
shows
significant
upward
trend
across
all
SDI
groups,
with
heavier
on
women,
especially
in
postmenopausal
female
population.
In
2021,
among
204
countries
territories,
top
3
largest
occurred
China,
India,
United
States.
three
highest
rate
Fiji,
Marshall
Islands,
Kiribati.
Conclusion
Our
study
reveals
that
is
increasing
rising
future.
Women
bear
particularly
there
are
differences
geographical
regions,
socioeconomic
statuses.
Targeted
considerations
specific
strategies
essential
address
these
disparities,
thereby
improving
public
health
reducing
burden.
Comprehensive physiology,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 1, 2025
ABSTRACT
Humans
are
perhaps
evolutionarily
engineered
to
get
deeply
addicted
sugar,
as
it
not
only
provides
energy
but
also
helps
in
storing
fats,
which
survival
during
starvation.
Additionally,
sugars
(glucose
and
fructose)
stimulate
the
feel‐good
factor,
they
trigger
secretion
of
serotonin
dopamine
brain,
associated
with
reward
sensation,
uplifting
mood
general.
However,
when
consumed
excess,
contributes
imbalance,
weight
gain,
obesity,
leading
onset
a
complex
metabolic
disorder,
generally
referred
diabetes.
Type
2
diabetes
mellitus
(T2DM)
is
one
most
prevalent
forms
diabetes,
nearly
affecting
all
age
groups.
T2DM
clinically
diagnosed
cardinal
sign
chronic
hyperglycemia
(excessive
sugar
blood).
Chronic
hyperglycemia,
coupled
dysfunctions
pancreatic
β‐cells,
insulin
resistance,
immune
inflammation,
further
exacerbate
pathology
T2DM.
Uncontrolled
T2DM,
major
public
health
concern,
significantly
toward
progression
several
micro‐
macrovascular
diseases,
such
diabetic
retinopathy,
nephropathy,
neuropathy,
atherosclerosis,
cardiovascular
including
cancer.
The
current
review
discusses
epidemiology,
causative
factors,
pathophysiology,
comorbidities,
existing
emerging
therapies
related
It
future
roadmap
for
alternative
drug
discovery
management
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 29, 2022
Atherosclerosis
is
one
of
the
main
complications
diabetes
mellitus,
involving
a
variety
pathogenic
factors.
Endothelial
dysfunction,
inflammation,
and
oxidative
stress
are
hallmarks
mellitus
atherosclerosis.
Although
ability
to
promote
atherosclerosis
has
been
demonstrated,
deeper
understanding
underlying
biological
mechanisms
critical
identifying
new
targets.
NLRP3
plays
an
important
role
in
both
While
diversity
its
activation
modes
causes
complex
effects
progression
atherosclerosis,
it
also
provides
many
insights
for
targeted
interventions
metabolic
diseases.
Soft Science,
Год журнала:
2022,
Номер
2(2), С. 9 - 9
Опубликована: Янв. 1, 2022
Wound
healing
is
one
of
the
most
complex
processes
in
human
body,
supported
by
many
cellular
events
that
are
tightly
coordinated
to
repair
wound
efficiently.
Chronic
wounds
have
potentially
life-threatening
consequences.
Traditional
dressings
come
direct
contact
with
help
them
heal
and
avoid
further
complications.
However,
traditional
some
limitations.
These
do
not
provide
real-time
information
on
conditions,
leading
clinicians
miss
best
time
for
adjusting
treatment.
Moreover,
current
diagnosis
relatively
subjective.
Wearable
electronics
become
a
unique
platform
monitor
conditions
continuous
manner
accurately
even
serve
as
accelerated
vehicles.
In
this
review,
we
briefly
discuss
status
objective
parameters/biomarkers
influencing
healing,
followed
presentation
various
novel
wearable
devices
used
monitoring
accelerating
healing.
We
summarize
associated
device
working
principles.
This
review
concludes
highlighting
major
challenges
toward
need
be
addressed
research
community.
Hepatology,
Год журнала:
2022,
Номер
76(5), С. 1409 - 1422
Опубликована: Март 25, 2022
Abstract
Background
and
Aims
Several
guidelines
recommend
screening
for
NAFLD
in
patients
with
type
2
diabetes
(T2D).
We
aimed
to
determine
if
there
is
a
threshold
of
age
duration
T2D
liver‐related
event
development
guide
strategies.
Approach
Results
conducted
territory‐wide
retrospective
cohort
study
adult
diagnosed
between
2000
2014
Hong
Kong
allow
at
least
5
years
follow‐up.
The
primary
endpoint
was
events,
defined
as
composite
HCC
cirrhotic
complications.
This
included
7028
(mean
age,
56.1
±
13.3
years;
3363
male
[47.9%]).
During
follow‐up
77,308
person‐years,
effect
1.1%,
4.9%,
94.0%
developing
events
the
<40,
40–50,
≥50
years,
respectively.
Similarly,
3.1%,
5.1%,
91.8%
developed
cirrhosis
In
contrast,
increased
linearly
duration,
no
difference
annual
incidence
rate
first
10
diagnosis
subsequent
(0.06%
vs.
0.10%;
p
=
0.136).
On
multivariable
analysis,
baseline
(adjusted
HR
[aHR]
2.01)
(aHR
3.12)
were
strongest
risk
factors
associated
events.
Substitution
aspartate
aminotransferase‐to‐platelet
ratio
index
or
Fibrosis‐4
yielded
similar
results.
Conclusions
Age
rather
than
predicts
T2D.
It
reasonable
screen
advanced
liver
disease
starting
50
age.
