Sports Medicine and Health Science,
Год журнала:
2023,
Номер
5(4), С. 251 - 258
Опубликована: Сен. 9, 2023
Exercise
has
well-characterized
therapeutic
benefits
in
the
management
of
type
2
diabetes
mellitus
(T2DM).
Most
beneficial
effects
exercise
arise
from
impact
nuclear
factor
erythroid
related
factor-2
(Nrf2)
activation
glucose
metabolism.
Nrf2
is
an
essential
controller
cellular
anti-oxidative
capacity
and
circadian
rhythms.
The
rhythm
influenced
by
genes
on
its
expression,
where
timing
rhythmicity
signaling,
such
that
differential
physiological
effects.
evening
management,
as
lowering
blood
weight.
mechanisms
responsible
for
these
have
not
yet
been
associated
with
influence
activity.
A
better
understanding
exercise-induced
signaling
can
improve
our
appreciation
distinct
morning
exercise.
This
review
hypothesizes
morning,
when
level
already
at
high
levels,
leads
to
hyperactivation
decrease
while
evening,
levels
are
nadir
improves
lowers
increases
fatty
acid
oxidation.
Exploring
activators
rhythmic
could
also
provide
valuable
insights
into
optimal
their
application,
holding
promise
timed
treatment
diabetes.
Journal of Activity Sedentary and Sleep Behaviors,
Год журнала:
2024,
Номер
3(1)
Опубликована: Янв. 5, 2024
Abstract
Background
Insufficient
sleep
has
been
linked
to
the
accumulation
of
cardiometabolic
risks
while
physical
activity
acts
as
a
protective
factor.
Also,
regularity
may
play
critical
role
in
maintaining
optimal
health.
This
cross-sectional
study
examined
association
between
device-based
regularity,
waking
behaviors,
and
health
markers,
including
blood
pressure
level;
abdominal
adiposity
glucose,
insulin,
cholesterol.
Methods
We
included
3698
members
Northern
Finland
Birth
cohort
1966
who
participated
follow-up
at
age
46
years
2012
2014
(women
61%).
used
seven-day
standard
deviations
bedtime,
wake-up
time,
time
bed
reflect
regularities.
As
covariates
linear
regression
models,
we
commonly
known
potential
risk
factors
(gender,
education,
marital
status,
work
schedule,
smoking
alcohol
use,
mean,
chronotype).
In
addition
previous,
either
sedentary
or
total
covariate
(B
coefficients
with
95%
confidence
intervals
CI).
Results
When
considered
other
covariates,
irregularities
were
associated
unfavorable
such
higher
body
mass
index
(bedtime
regularity:
0.194,
CI
[0.072,
0.316],
p
=
0.002);
diastolic
levels
(time
0.175,
[0.044,
0.306],
0.009);
2-h
glucose
(wake-up
0.107,
[0.030,
0.184],
0.006).
only
irregular
bedtime
was
waist
circumference
0.199,
[0.042,
0.356],
0.013).
Irregularities
not
pressure,
visceral
fat
area
fasting
insulin
level
after
considering
(in
all,
>
0.05).
Conclusions
middle-aged,
appears
weaken
adverse
relationship
although
interpretation
impact
remains
less
conclusive.
The
clinical
significance
extent
observed
associations
warrant
further
investigation.
The Journal of Physiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 24, 2024
Abstract
Exercise
is
recommended
in
the
treatment
of
type
2
diabetes
and
can
improve
insulin
sensitivity.
However,
previous
evidence
suggests
that
exercise
at
different
times
day
people
with
may
have
opposing
outcomes
on
glycaemia.
Metformin
most
commonly
prescribed
initial
pharmacological
intervention
diabetes,
alter
adaptions
to
exercise.
It
unknown
if
there
an
interaction
between
metformin
diurnal
outcomes.
We
aimed
investigate
glycaemic
moderate
intensity
morning
vs
.
evening
being
monotherapy.
In
this
study,
nine
males
females
undergoing
monotherapy
(age
61
±
8.2
years,
mean
SD)
completed
a
16‐week
crossover
trial
including
2‐week
baseline
recording,
6
weeks
randomly
assigned
(07.00–10.00
h)
or
(16.00–19.00
wash‐out
period.
arms
consisted
30
min
walking
70%
estimated
max
heart
rate
every
other
day.
Glucose
levels
were
measured
continuous
glucose
monitors
activity
by
wrist‐worn
monitors.
Food‐intake
was
recorded
4‐day
food
diaries
during
baseline,
first
last
each
arm.
There
no
difference
intensity,
total
caloric
intake
physical
arms.
As
primary
outcomes,
acute
(24
area
under
curve
(AUC),
lower
(
P
=
0.02)
after
(180.6
68.4
mmol/l)
compared
(210.3
76.7
mmol/l);
differences
identified
for
(mmol/l)
any
specific
time
point
when
data
analysed
two‐way
ANOVA.
secondary
AUC
significantly
0.01)
participants
taking
before
breakfast
(152.5
29.95
(227.2
61.51
only
arm;
5–6
protocol,
0.04)
(168.8
15.8
mmol/l),
rather
than
(224.5
52.0
Our
reveal
acutely
lowers
metformin.
This
appears
be
driven
individuals
consumed
prior
breakfast.
beneficial
effect
upon
combined
pre‐breakfast
persisted
through
final
trial.
findings
suggest
benefit
management
glycaemia
diabetes.
image
Key
points
Morning
persistently
reduced
post‐breakfast
week
(week
6)
intervention.
study
it
possible
make
simple
changes
take
perform
their
blood
glucose.
Abstract
Background
Physical
activity
reduces
colorectal
cancer
risk,
yet
the
diurnal
timing
of
physical
in
etiology
remains
unclear.
Methods
This
study
used
24-h
accelerometry
time
series
from
UK
Biobank
participants
aged
42
to
79
years
derive
circadian
patterns
using
functional
principal
component
analysis.
Multivariable
Cox
proportional
hazard
models
were
examine
associations
with
risk.
Results
Among
86,252
(56%
women),
529
cases
occurred
during
a
median
5.3-year
follow-up.
We
identified
four
that
explained
almost
100%
data
variability
day.
A
pattern
continuous
day-long
was
inversely
associated
risk
(hazard
ratio
(HR)
=
0.94,
95%
confidence
interval
(CI)
0.89–0.99).
second
late-day
suggestively
related
(HR
0.93,
CI
0.85–1.02).
third
early-
plus
decreased
0.89,
0.80–0.99).
fourth
mid-day
night-time
showed
no
relation
1.02,
0.88–1.19).
Our
results
consistent
across
various
sensitivity
analyses,
including
restriction
never
smokers,
exclusion
first
2
follow-up,
and
adjustment
for
shift
work.
Conclusions
is
reduced
beyond
benefits
overall
activity.
Further
research
needed
confirm
role
prevention.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 18, 2025
The
triglyceride-glucose
(TyG)
index,
a
readily
accessible
surrogate
biomarker
for
insulin
resistance
and
metabolic
health,
has
been
extensively
investigated
across
various
ethnic
populations.
critical
role
of
physical
activity
(PA)
in
enhancing
sensitivity
corroborated
by
numerous
studies.
Nonetheless,
the
relationship
between
different
patterns
PA
TyG
index
remains
ambiguous.
This
study
seeks
to
elucidate
association
index.
Participants
with
complete
data
on
patterns,
other
covariates
from
National
Health
Nutrition
Examination
Survey
database
(2007-2018)
were
included
this
study.
Participant
characteristics
groups
compared
using
Rao-Scott
chi-squared
test
or
Kruskal-Wallis
test.
Multivariate
linear
regression
models
used
assess
subgroup
analyses,
interaction
tests
restricted
cubic
spline
(RCS)
analyses
conducted
explore
stability
potential
nonlinearity
PA-TyG
association,
respectively.
A
total
16,440
participants
included,
12,909,
164,
118,
3249
individuals
being
inactive,
insufficiently
active,
weekend
warriors
(WWs),
regularly
active
(RA),
adjusted
showed
that
adults
(β
=
-
0.05,
P
0.3524),
WWs
-0.01,
0.9129),
RA
0.110,
<
0.0001)
all
had
significantly
lower
indices
inactive
adults.
Significant
difference
was
observed
(P
trend
0.0001).
Stratified
interact
revealed
group
more
pronounced
male,
higher
education
levels,
without
diabetes.
Additionally,
significant,
non-linear,
negative
weekly
non-inactive
determined
RCS
analysis
overall
0.001,
0.054).
Being
is
linked
substantial
reduction
whereas
those
insufficient
do
not
experience
comparable
benefits.
Nevertheless,
warrior
approach
can
provide
practical
alternative
who
are
unable
engage
consistent
exercise.
BIO Web of Conferences,
Год журнала:
2025,
Номер
157, С. 01001 - 01001
Опубликована: Янв. 1, 2025
National
salt
demand
increases
every
year
along
with
the
growth
in
and
consumption.
However,
production
decreased
2019-2022.
This
encourages
innovation
evaporation,
namely
Flow
Down
System
method,
which
is
a
seawater
evaporation
that
saves
land.
research
aims
to
analyse
process,
effectiveness,
efficiency
of
Traditional
method
Innovation.
The
used
Purposive
Sampling
get
statistical
data
processed
RStudio.
result
this
reduces
land
time
compared
traditional
method.
more
effective
an
average
effectiveness
98.69%-98.73%
98.37%-98.69%.
Down’s
NaCl
content
(44.25%)
(-24.02%)
although
moisture
was
slightly
better
(46.5%
vs.
44,29%).
efficient
100%-time
33.33%.
sales
100%
(IDR
239,680/month)
surpassed
33.18%
79,550/month).
profit
105,710.32)
75.25%.
With
16,515
kWh
electrical
energy,
making
it
superior
SNI
standard.
Nutrition Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
The
circadian
clock
is
an
endogenous
timekeeping
system
that
regulates
various
physiological
and
behavioral
processes.
Recently,
it
has
been
shown
the
timing
of
physical
activity
food
intake
can
significantly
influence
metabolic
muscle
health.
Some
recent
clinical
evidence
practiced
in
late
afternoon
be
more
effective
terms
performance
strength.
Preclinical
studies
have
highlighted
explanation
for
this
effect
lies
different
daily
expression
genes
clock-controlled
involved
development
hypertrophy.
In
conjunction
with
scientific
advances
understanding
molecular
mechanisms
regulate
rhythms
trophy,
chrono-nutrition
gained
resonance
become
a
promising
field,
aimed
at
regulation
body
metabolism.
Clinical
preclinical
protein
consumption
specific
time
points
during
day,
or
precisely
after
exercise,
activate
signaling
pathways
synthesis
and,
thus,
favor
skeletal
mass
as
well
mitochondrial
biogenesis,
thereby
improving
cell
energy
production
function.
On
other
hand,
some
carbohydrates
immediately
exercise
increases
insulin
secretion,
which
facilitates
glucose
uptake
by
cells
to
replenish
glycogen.
This
review
summarizes
current
literature
concerning
chrono-exercise
health,
focusing
on
involving
mass,
strength,
Understanding
intricate
relationship
between
rhythms,
nutrition,
metabolism
essential
optimizing
nutritional
strategies
prevent
treat
wasting.
addition,
tailoring
carbohydrate
individual
needs
improve
maintenance,
growth,
performance.
