Nutrition and Diabetes,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 22, 2025
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
common
complication
of
type
2
diabetes
mellitus
(DM).
The
transcription
factor
zinc
fingers
and
homeoboxes
(ZHX2)
has
been
implicated
in
the
pathogenesis
chronic
diseases,
yet
its
precise
role
underlying
mechanism
DM-induced
hepatic
injury
remain
poorly
elucidated.
To
investigate
this,
we
used
high-fat
diet
(HFD)
streptozotocin
(STZ)
administration
to
create
DM
model
mice,
while
high
glucose
(HG)
exposure
was
simulate
vitro.
Through
various
experiments
such
as
luciferase
reporter
assay,
chromatin
immunoprecipitation,
RNA
rescue
experiments,
aimed
uncover
mechanisms
involving
ZHX2.
Our
findings
revealed
that
ZHX2
lower
YTHDF2
higher
livers
mice
HG-induced
Huh7
cells.
overexpression
rescued
injury.
also
reversed
ferroptosis
vivo
Mechanistically,
recognized
m6A-modified
mRNA
promoted
degradation.
In
turn,
inhibited
by
binding
promoter
region.
Knockdown
led
increased
cells
through
activating
YTHDF2-induced
GPX4
SLC7A11
These
highlight
involvement
ZHX2-YTHDF2-ferroptosis
pathway
suggest
targeting
this
may
hold
therapeutic
potential
for
improving
injuries.
BMC Pulmonary Medicine,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 8, 2025
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
leading
cause
of
global
morbidity
and
death.
The
blood
urea
nitrogen-to-creatinine
ratio
(BCR)
recognized
as
crucial
marker
to
assess
renal
function
cardiovascular
risk.
Nevertheless,
the
effects
BCR
on
COPD
patients
suffering
comorbid
congestive
heart
failure
(CHF)
not
clarified.
This
study
aims
elucidate
association
between
CHF
risk
in
population.
Data
from
meeting
eligibility
criteria
were
Medical
Information
Mart
for
Intensive
Care
IV
(MIMIC-IV)
database.
cumulative
incidence
curve
was
utilized
examining
link
CHF.
Kaplan-Meier
(KM)
analysis
carried
out
evaluating
relation
in-hospital
mortality(IHM).
Multivariable
Cox
regression
assisted
assessing
correlation
with
Restricted
cubic
splines
(RCS)
leveraged
unraveling
(as
continuous
variable)
Our
included
2,840
intensive
care
unit
first
time,
hospital
stays
exceeding
24
h.
57.18%
among
these
patients.
Cumulative
demonstrated
notably
increased
having
higher
(18.889
<
≤
92.5)
contrast
those
lower
(2.877
18.889)
(p
0.0001).
KM
survival
indicated
markedly
elevated
IHM
comparison
RCS
further
confirmed
that
linked
risen
likelihood
[hazard
(HR)
=
1.28,
95%
confidence
interval
(CI,
1.15–1.44),
p
0.001].
Subgroup
revealed
[HR
1.41,
CI
(1.13–1.76),
0.002]
diabetes
than
without
1.24,
(1.08–1.41),
0.002].
Elevated
an
independent
factor
critically
ill
individuals
strongly
related
findings
prove
reliable
clinical
predictor,
facilitating
stratification
personalized
treatment
Diabetes Research and Clinical Practice,
Год журнала:
2025,
Номер
unknown, С. 112095 - 112095
Опубликована: Март 1, 2025
Diabetes
mellitus
(DM)
may
lead
to
microvascular
and
macrovascular
complications.
Screening
for
these
complications
is
crucial
non-invasive
methods
with
high-dissemination
potential
are
needed.
Diabetic
peripheral
neuropathy
(DPN)
particularly
challenging
screen
due
the
lack
of
reliable
clinical
markers
endpoints.
In
this
context,
Raster
Scan
Optoacoustic
Mesoscopy
(RSOM)
emerges
as
a
highly
promising
technique
that
offers
hybrid,
imaging
optical
absorption
using
light-induced
ultrasound
waves
within
tissue
without
use
contrast
agents.
RSOM
provides
high-resolution
visualisation
micro-vasculature,
other
structures
functional
information.
The
has
already
assessed
microvasculature
loss
function
diabetes
progression
used
it
characterise
DPN
severity.
also
shown
cutaneous
vessels
in
mesoscopic
range
(mean
diameters
30–40
µm)
most
prominently
affected
by
DM
mean
number
was
lower
subjects
than
healthy
participants
(p
<
0.001
p
0.05,
respectively).
Although
experience
still
limited,
we
present
an
overview
novel
relation
its
detecting
early
onset
development
mircovascular
Journal of Diabetes Research,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Background:
It
remains
unclear
whether
cholesterol-lowering
therapy
can
reduce
the
incidence
of
microvascular
complications
in
patients
with
diabetes.
We
aim
to
explore
potential
causal
relationship
between
three
common
types
drugs
and
diabetic
through
drug-target
Mendelian
randomization
(MR)
study,
laying
groundwork
for
development
new
medications.
Methods:
In
this
we
collected
single
nucleotide
polymorphisms
(SNPs)
associated
HMGCR
(3-hydroxy-3-methylglutaryl-CoA
reductase)
inhibitors,
PCSK9
(proprotein
convertase
subtilisin/kexin
type
9)
NPC1L1
(Niemann-Pick
C1-Like
1)
inhibitors
from
published
genome-wide
association
study
statistics.
Subsequently,
MR
analyses
were
performed
investigate
effects
these
on
low-density
lipoprotein
cholesterol
(LDL-C)
level-mediated
diabetes
mellitus.
Coronary
atherosclerosis
as
a
positive
control.
Primary
outcomes
included
nephropathy,
retinopathy,
neuropathy
FinnGen
Consortium.
Results:
The
analysis
revealed
significant
associations
inhibition
increased
risks
nephropathy
(OR
[95%confidence
interval
(CI)]
=
1.88
[1.50,
2.36],
p
5.55
×
10-8),
retinopathy
[95%CI]
1.86
[1.54,
2.24],
6.28
10-11),
2.63
[1.84,
3.75],
1.14
10-7)
using
inverse
variance
weighted
method.
have
been
an
risk
1.30
[1.07,
1.58],
0.009)
1.40
[1.15,
1.72],
0.001);
significantly
0.48
[0.28,
0.85],
0.01).
coronary
heart
disease
Conclusions:
findings
show
that
may
increase
complications.
However,
provide
protection
against
retinopathy.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 17, 2025
Circular
RNAs
(circRNAs),
constituting
a
novel
class
of
endogenous
non-coding
generated
through
the
reverse
splicing
mRNA
precursors,
possess
capacity
to
regulate
gene
transcription
and
translation.
Recently,
pivotal
role
circRNAs
in
controlling
vascular
aging,
as
well
pathogenesis
progression
aging-related
diseases,
has
garnered
substantial
attention.
Vascular
aging
plays
crucial
increased
morbidity
mortality
elderly.
Endothelial
cells
(ECs)
smooth
muscle
(VSMCs)
are
components
intima
media
layers
wall,
respectively,
closely
involved
mechanisms
underlying
diseases.
The
review
aims
provide
comprehensive
exploration
connection
between
Besides,
circRNAs,
potential
diagnostic
markers
or
therapeutic
targets
for
will
be
discussed
thoroughly,
along
with
challenges
limitations
their
clinical
application.
Investigating
molecular
diseases
insight
into
early
diagnosis
therapy,
even
effective
prognosis
assessment
these
conditions.
Antioxidants,
Год журнала:
2025,
Номер
14(4), С. 398 - 398
Опубликована: Март 27, 2025
Hydroxytyrosol
(HT),
a
principal
bioactive
phytochemical
abundant
in
Mediterranean
dietary
sources,
has
emerged
as
molecule
of
significant
scientific
interest
owing
to
its
multifaceted
health-promoting
properties.
Accumulating
evidence
suggests
that
HT’s
therapeutic
potential
metabolic
disorders
extends
beyond
conventional
antioxidant
capacity
encompass
mitochondrial
regulatory
networks.
This
review
synthesizes
contemporary
from
our
systematic
investigations
and
the
existing
literature
delineate
comprehensive
modulatory
effects
on
homeostasis.
We
systematically
summarized
impact
HT
dynamics
(fusion/fission
equilibrium),
biogenesis
energy
metabolism,
mitophagy,
inter-organellar
communication
with
endoplasmic
reticulum,
microbiota–mitochondria
crosstalk.
Through
this
multidimensional
analysis,
we
established
homeostasis
modulator
applications
syndrome
(MetS)
related
pathologies
including
type
2
diabetes
mellitus,
obesity-related
dysfunction,
dyslipidemia,
non-alcoholic
steatohepatitis,
hypertension-related
complications.
Moreover,
further
discussed
translational
challenges
research,
emphasizing
imperative
for
direct
target
identification,
mitochondrial-targeted
delivery
system
development,
combinatorial
strategies.
Collectively,
provides
mechanistic
framework
advancing
research
accelerating
clinical
implementation
MetS
diseases.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Май 3, 2024
Background
In
recent
years,
several
studies
have
explored
the
effect
of
metformin
on
myocardial
infarction
(MI),
but
whether
has
an
improvement
in
patients
with
MI
is
controversial.
This
study
was
aimed
to
investigate
causal
relationship
between
and
using
Mendelian
randomization
(MR)
analysis.
Methods
The
genome-wide
significant
(
P
<5×10
-8
)
single-nucleotide
polymorphisms
(SNPs)
were
screened
from
Open
association
(GWAS)
project
as
instrumental
variables
(IVs).
outcomes
mainly
included
MI,
old
acute
transmural
inferior
wall,
anterior
wall.
inverse
variance
weighted
(IVW)
method
applied
assess
main
effect,
median,
simple
mode,
mode
methods,
MR-Egger
regression
auxiliary
for
supplementary
proof.
assessed
odds
ratios
(OR)
95%
confidence
intervals
(95%
CI).
A
leave-one-out
used
explore
individual
SNPs
results
IVW
analyses,
a
funnel
plot
analyze
potential
bias
results,
thus
ensuring
robustness
results.
Results
total,
16,
84,
39,
26,
34
selected
IVs
genetic
respectively.
Treatment
does
not
affect
risk
wall
at
level
>0.05;
OR
1.010).
cases
may
even
be
factor
<0.05;
ORs
1.078,
1.026,
1.022
1.018
respectively).
There
no
horizontal
pleiotropy
or
heterogeneity
among
IVs.
stable
when
removing
one
by
one.
Conclusion
Metformin
protective
against
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 2, 2024
Gut
microbiota
(GM)
homeostasis
in
the
human
body
is
closely
associated
with
health,
which
can
be
used
as
a
regulator
for
preventing
onset
and
progression
of
disease.
Diabetic
microvascular
complications
bring
about
not
only
huge
economic
burden
to
society,
but
also
miserable
mental
physical
pain.
Thus,
alteration
GM
may
method
delay
diabetic
complications.
