Neurochemical Journal, Год журнала: 2024, Номер 18(4), С. 603 - 616
Опубликована: Дек. 1, 2024
Язык: Английский
Cell, Год журнала: 2024, Номер 187(15), С. 3789 - 3820
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
30
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер unknown, С. 167825 - 167825
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Scandinavian Journal of Primary Health Care, Год журнала: 2025, Номер unknown, С. 1 - 7
Опубликована: Янв. 28, 2025
In addition to peripheral neuropathy of various kinds, diabetes can also cause central neuropathy, which among other things manifest itself as premature cognitive dysfunction, often linked vascular dysfunction. Although the link between and dysfunction was discovered more than 100 years ago has important clinical implications, this complication remains relatively unknown. Recent have seen research that clarified cerebral insulin resistance defective signaling examples pathogenic factors behind impairment in diabetes. We provide a narrative review select contemporary publications with relevance for interface diabetes/prediabetes function. Recently published studies show physical activity reverse brain well pathological appetite regulation. Pharmacological interventions with, example, nasal insulin, GLP-1 receptor agonists, SGLT-2 inhibitors, or PPAR-γ agonists shown promising results. Optimization lifestyle (e.g. activity), several pharmaceutical agents already use against diabetes, results improving function diabetic patients. An task primary health care, where most patients type 2 are diagnosed, treated, followed, is increase awareness early detection these optimizing risk factor control.
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 279 - 279
Опубликована: Фев. 19, 2025
Type 2 diabetes (T2D) and metabolic (dysfunction)-associated steatotic liver disease (MASLD) affect a growing number of individuals worldwide. T2D MASLD often coexist substantially elevate the risk adverse hepatic cardiovascular clinical outcomes. Several common pathogenetic mechanisms are responsible for onset progression, including insulin resistance, oxidative stress, low-grade inflammation, among others. The latter can also be induced by gut microbiota its derived metabolites. Natural bioactive compounds (NBCs) have been reported their therapeutic potential in both MASLD. A large amount evidence obtained from trials suggests that like berberine, curcumin, soluble fibers, omega-3 fatty acids exhibit significant hypoglycemic, hypolipidemic, hepatoprotective activity humans may employed as adjunct therapy management. In this review, role most studied NBCs management is discussed, emphasizing recent supporting these compounds' efficacy safety. Also, prebiotics act against dysfunction modulating evaluated.
Язык: Английский
Процитировано
0
Brain stimulation, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Metabolism, Год журнала: 2024, Номер 164, С. 156104 - 156104
Опубликована: Дек. 12, 2024
Язык: Английский
Процитировано
2
Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16
Опубликована: Июль 3, 2024
Background Cognitive function ( CF ) deterioration is a pressing concern in geriatric research. This study aimed to explore the relationship between physical activity (PA) and older adults. Methods adopted dual approach, employing both observational genetic approaches through data from National Health Nutrition Examination Survey (NHANES) 2011–2014 Mendelian Randomization (MR) analysis. For NHANES component, PA levels were evaluated using Global Physical Activity Questionnaire, was assessed via standardized tests. Multivariate regression, threshold effect analysis, smoothing curve fitting, subgroup analyses conducted examine association CF. In parallel, MR methods, variants as instrumental variables, causal impact of on related conditions such Alzheimer’s disease dementia. Results Observational findings demonstrated positive correlation , notably among female participants. The detailed analysis identified specific thresholds that correlate with cognitive enhancements. However, results did not support significant or dementia-related outcomes, indicating an absence direct basis for associations. Conclusion Although suggest positively associated adults, particularly women, confirm these causally related. discrepancy highlights complexity PA- underscores need further These emphasize potential modifiable risk factor though effects remain be definitively established.
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Дек. 12, 2024
Abstract Background Reduced inhibitory control is associated with obesity and neuroimaging studies indicate that diminished prefrontal cortex activity influence eating behavior metabolism. The hypothalamus regulates energy homeostasis functionally connected to cortical subcortical regions especially the frontal areas. Objectives We tested network-targeted transcranial direct current stimulation (net-tDCS) excitability of brain involved in appetite control. Methods In a randomized, double-blind parallel group design, 44 adults overweight or (BMI 30.6 kg/m 2 , 52.3 % female) received active (anodal cathodal) sham 12-channel net-tDCS on appetite-control network for 25 minutes three consecutive days while performing Stop-Signal-Task measure response inhibition. Before after stimulation, state questionnaires assessed changes desire eat food craving. Directly participants breakfast buffet evaluate ad-libitum intake. An oral glucose tolerance test was conducted at follow-up. Resting-state functional MRI obtained baseline Results Stop-Signal Reaction Time (SSRT) shorter both groups versus sham, indicating improved Additionally, stronger increase hypothalamic connectivity SSRT. Caloric intake sweet lower anodal but no main effects between were observed total macronutrient intake, craving ratings eat. At follow-up, differences peripheral Conclusion Our study suggests modulating patterns via may improve choice Graphical Highlights Active showed better compared group. Stronger net-tDCS. No found kilocaloric Anodal
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2024, Номер 20(5), С. 622 - 627
Опубликована: Май 21, 2024
Die Untersuchung intraindividueller Unterschiede des Stoffwechsels und Diabetesrisikos führte zur Identifizierung von Subgruppen Prädiabetes Diabetes mellitus. Diese unterscheiden sich in ihrem Risiko für Komplikationen ihrer Mortalität deutlich. mit hohem Komplikationsrisiko sind u. a. durch eine spezifische Körperfettverteilung vermehrtem viszeralem Fett gekennzeichnet. Ihr spezifischer Phänotyp ähnelt jenem Personen einer Insulinresistenz im Gehirn. Dies weist auf mögliche pathophysiologische Rolle der Gehirninsulinresistenz Entwicklung dieser Risikogruppen hin, die bei relevanten Anzahl an vorhanden ist. Insulin wirkt nicht nur peripheren Geweben, sondern auch menschlichen Während es dort normalerweise das Essverhalten beeinflusst, den Stoffwechsel Organen koordiniert sogar Gedächtnisprozesse Einfluss nimmt, diese regulatorischen Funktionen Gehirns gestört. Langfristig scheint dies viszerale Fettakkumulation zu begünstigen. Dabei ist Insulinwirkung Gehirn zwischen Geschlechtern unterschiedlich, Menstruationszyklus Insulinempfindlichkeit zentralnervöse Regulation beeinflussen. Ergebnisse erster kleinerer Studien deuten darauf dass potenziell behandelbar Zukünftige müssen klären, inwieweit verbesserte präventiv oder therapeutisch genutzt werden kann, um Hochrisikopersonen behandeln deren reduzieren.
Процитировано
0
Journal of Diabetes Investigation, Год журнала: 2024, Номер 15(11), С. 1537 - 1544
Опубликована: Авг. 20, 2024
Diabetic neuropathy is one of the most serious and common complications diabetes with a wide spectrum, affecting 30-50% diabetic patients. However, current treatments this disorder, mainly based on controlling blood glucose level, show an inadequate clinical outcome. Better approaches are needed. In fashion, it noted that promoting nerve regeneration preventing degeneration should be focused equally appropriately. mini review, how more effective in targeting PI3K/AKT MEK/ERK pathways treatment peripheral discussed. Future consider these approaches.
Язык: Английский
Процитировано
0