Diabetes mellitus—Progress and opportunities in the evolving epidemic

Cell, Год журнала: 2024, Номер 187(15), С. 3789 - 3820

Опубликована: Июль 1, 2024

Язык: Английский

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Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver Disease

Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 279 - 279

Опубликована: Фев. 19, 2025

Type 2 diabetes (T2D) and metabolic (dysfunction)-associated steatotic liver disease (MASLD) affect a growing number of individuals worldwide. T2D MASLD often coexist substantially elevate the risk adverse hepatic cardiovascular clinical outcomes. Several common pathogenetic mechanisms are responsible for onset progression, including insulin resistance, oxidative stress, low-grade inflammation, among others. The latter can also be induced by gut microbiota its derived metabolites. Natural bioactive compounds (NBCs) have been reported their therapeutic potential in both MASLD. A large amount evidence obtained from trials suggests that like berberine, curcumin, soluble fibers, omega-3 fatty acids exhibit significant hypoglycemic, hypolipidemic, hepatoprotective activity humans may employed as adjunct therapy management. In this review, role most studied NBCs management is discussed, emphasizing recent supporting these compounds' efficacy safety. Also, prebiotics act against dysfunction modulating evaluated.

Язык: Английский

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Intermittent fasting and neurodegenerative diseases: Molecular mechanisms and therapeutic potential

Metabolism, Год журнала: 2024, Номер 164, С. 156104 - 156104

Опубликована: Дек. 12, 2024

Язык: Английский

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Cognitive dysfunction in diabetes – the ‘forgotten’ diabetes complication: a narrative review

Scandinavian Journal of Primary Health Care, Год журнала: 2025, Номер unknown, С. 1 - 7

Опубликована: Янв. 28, 2025

In addition to peripheral neuropathy of various kinds, diabetes can also cause central neuropathy, which among other things manifest itself as premature cognitive dysfunction, often linked vascular dysfunction. Although the link between and dysfunction was discovered more than 100 years ago has important clinical implications, this complication remains relatively unknown. Recent have seen research that clarified cerebral insulin resistance defective signaling examples pathogenic factors behind impairment in diabetes. We provide a narrative review select contemporary publications with relevance for interface diabetes/prediabetes function. Recently published studies show physical activity reverse brain well pathological appetite regulation. Pharmacological interventions with, example, nasal insulin, GLP-1 receptor agonists, SGLT-2 inhibitors, or PPAR-γ agonists shown promising results. Optimization lifestyle (e.g. activity), several pharmaceutical agents already use against diabetes, results improving function diabetic patients. An task primary health care, where most patients type 2 are diagnosed, treated, followed, is increase awareness early detection these optimizing risk factor control.

Язык: Английский

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Exploring the connection between dementia and cardiovascular risk with a focus on ADAM10

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер unknown, С. 167825 - 167825

Опубликована: Март 1, 2025

Язык: Английский

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Repeated net-tDCS of the hypothalamus appetite-control network enhances inhibitory control and decreases sweet food intake in persons with overweight or obesity

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Mediating role of Interleukin-6 in the predictive association of diabetes with Hippocampus atrophy, Amyloid, Tau, and Neurofilament pathology at pre-clinical stages of diabetes-related cognitive impairment

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Type-2 diabetes (T 2 DM) has been associated with higher dementia risks, but the mechanisms are still unclear, and there is increasing evidence of role cytokines. Interleukin-6 (IL-6) mediating effect never explored. The study included a subset 1,927 participants from Health Aging Brain Study: Healthy Disparities (HABS-HD) cohort complete data. Cross-sectional longitudinal analyses were performed. Associations studied using multivariable linear, logistic, mediation analysis non-parametric bootstrapping. T DM IL-6 worse executive function, Hippocampus atrophy, lower Aß 42 /Aß 40 ratio, , total Tau, NfL levels. mediated 5% association ([1.5%-10%], p- value<2×10 -16 ), 4% ([0.7%-11%], value=0.014), 8% TMT-B ([0.2%-35%], value=0.046), 11% Tau ([2.5%-40%], value=0.010), ([1.6%-8%], 12% hippocampus atrophy ([3%-49%], value=0.004). results, except TMT-B, replicated in long-lasting on non-previously diagnosed cognitive impairment. captured pre-clinical stage DM-dementia association. novelty that to be further explored accounted for risk stratification preventive measures, particularly ethnic minorities.

Язык: Английский

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Brain-Body Communication in Glucose Metabolism

Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown, С. 63 - 81

Опубликована: Янв. 1, 2025

Язык: Английский

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Metabolism and puberty

Problems of Biological Medical and Pharmaceutical Chemistry, Год журнала: 2025, Номер unknown, С. 14 - 18

Опубликована: Май 18, 2025

Human nutrition affects puberty. The nature of is determined by the socio-economic conditions society and family, genetic epigenetic factors. Micro- macronutrients, hormones modulate growth and/or signal nutritional status energy available for maturation. onset puberty delayed in response to chronic deficiency accelerated case its excess. Late increases likelihood cardiovascular, musculoskeletal neurocognitive disorders. Early a risk factor obesity, type 2 diabetes, some types cancer. authors discuss mechanisms determining influence metabolism on sexual development, pubertal disorders metabolic defects, diseases.

Язык: Английский

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Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Июль 3, 2024

Background Cognitive function ( CF ) deterioration is a pressing concern in geriatric research. This study aimed to explore the relationship between physical activity (PA) and older adults. Methods adopted dual approach, employing both observational genetic approaches through data from National Health Nutrition Examination Survey (NHANES) 2011–2014 Mendelian Randomization (MR) analysis. For NHANES component, PA levels were evaluated using Global Physical Activity Questionnaire, was assessed via standardized tests. Multivariate regression, threshold effect analysis, smoothing curve fitting, subgroup analyses conducted examine association CF. In parallel, MR methods, variants as instrumental variables, causal impact of on related conditions such Alzheimer’s disease dementia. Results Observational findings demonstrated positive correlation , notably among female participants. The detailed analysis identified specific thresholds that correlate with cognitive enhancements. However, results did not support significant or dementia-related outcomes, indicating an absence direct basis for associations. Conclusion Although suggest positively associated adults, particularly women, confirm these causally related. discrepancy highlights complexity PA- underscores need further These emphasize potential modifiable risk factor though effects remain be definitively established.

Язык: Английский

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