Diabetes Technology & Therapeutics, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Autonomic neuropathy is associated with dysglycemia that difficult to control. We investigated if transcutaneous vagus nerve stimulation (tVNS) could improve glycemic levels.
Язык: Английский
Physiological Reports, Год журнала: 2025, Номер 13(3)
Опубликована: Фев. 1, 2025
Abstract Emerging evidence suggests that the vagus nerve can modulate immune system in experimental settings. Vagus stimulation (VNS), initially developed for managing epilepsy, is now being explored as a treatment autoimmune diseases due to its potential immunomodulatory effects. This systematic review evaluates therapeutic of VNS by critically appraising findings from human clinical studies. was conducted accordance with PRISMA guideline, comprehensive literature search performed Ovid, Cochrane, and PubMed databases up July 2024. Studies focusing on patients were eligible, quality study assessed using QualSyst tool. Of 53 papers identified full‐text assessment, 19 studies met eligibility criteria. Findings suggest promising adjunctive therapy Crohn's disease rheumatoid arthritis, showing alleviate symptoms responses. The efficacy safety vary widely across studies, highlighting complex nature diverse mechanisms action. Future research should prioritize large‐scale, randomized controlled trials standardized protocols further elucidate efficacy, long‐term safety, optimal parameters various conditions.
Язык: Английский
Процитировано
1
Frontiers in Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Авг. 16, 2024
Background Transcutaneous Vagal Nerve Stimulation (tVNS) has been used as a promising noninvasive neuromodulation technique for the treatment of various systems.The aim this study was to analyze research hotspots and future directions tVNS in 21st century by using bibliometric methods. Methods The object literature related from Web Science database 2000 May 2024. In order measure number issuance, institutions, authors, countries, keywords, co-citations, journals publication, we VOSviewer, Citespace, Bibliometrix R-package, Scimago Graphica software. A narrative review current content conducted gain better understanding state field. Results total 569 papers were included study. results show that 2024, publications shows an increasing trend year year, involving 326 institutions. United States, China, Germany are major centers. identified 399 which roughly formed 11 natural clusters, revealing mainly reflected 3 areas: intervention efficacy on nervous system diseases, mechanism action tVNS, stimulation mode tVNS. top 10 most cited references focus into Conclusion safety have confirmed previous studies, but standardized protocol not yet developed, clinical studies small sample sizes lack multicenter multidisciplinary collaboration. Currently, is neurological psychiatric cardiovascular some autoimmune diseases. It expected field will continue application central diseases exploration mechanisms, at same time, with rise non-invasive technology, other also great potential development.
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Сен. 9, 2024
Язык: Английский
Процитировано
3
Neurogastroenterology & Motility, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Diabetic gastroenteropathy can cause significant diagnostic challenges. Still, it remains unknown if measures of extraintestinal autonomic function reflect diabetic gastroenteropathy. We aimed to assess the associations between (1) gastrointestinal symptoms and motility (2) symptoms/motility markers.
Язык: Английский
Процитировано
3
Biomolecules, Год журнала: 2025, Номер 15(4), С. 499 - 499
Опубликована: Март 29, 2025
Patients with type 2 diabetes mellitus (T2DM) predominantly experience mortality due to cardiovascular diseases (CVD), particularly in low- and middle-income nations. Among these, heart failure (HF) is the most severe complication terms of prognosis management. Despite advancements individualized glycemic control risk management, including development novel glucose- lipid-lowering agents, prevalence HF T2DM patients remains persistently high. This indicates that factors beyond hyperglycemia significantly contribute heightened associated T2DM. review examines critical influencing CVD T2DM, roles reduced rate variability (HRV), a marker autonomic dysfunction, chronic inflammation, both which play pivotal pathogenesis. Recent evidence highlights potential vagus nerve activation modulate these factors, underscoring its capacity reduce T2DM-related complications. Specifically, we discuss therapeutic promise transcutaneous auricular stimulation (taVNS) as non-invasive intervention enhance vagal tone, decrease systemic improve outcomes By addressing interplay among HRV, microvascular disease, this provides comprehensive perspective on utility taVNS managing
Язык: Английский
Процитировано
0
World Journal of Gastrointestinal Pharmacology and Therapeutics, Год журнала: 2024, Номер 15(5)
Опубликована: Сен. 3, 2024
The gastrointestinal symptom rating scale (GSRS) is a questionnaire in English language which designed to assess the clinical symptoms patients with irritable bowel syndrome (IBS) and peptic ulcer disease. This validated has questions on around 15 items been dyspepsia IBS.
Язык: Английский
Процитировано
0
Diabetes Technology & Therapeutics, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Autonomic neuropathy is associated with dysglycemia that difficult to control. We investigated if transcutaneous vagus nerve stimulation (tVNS) could improve glycemic levels.
Язык: Английский
Процитировано
0