Depression Pathophysiology: Astrocyte Mitochondrial Melatonergic Pathway as Crucial Hub

International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 350 - 350

Опубликована: Дек. 26, 2022

Major depressive disorder (MDD) is widely accepted as having a heterogenous pathophysiology involving complex mixture of systemic and CNS processes. A developmental etiology coupled to genetic epigenetic risk factors well lifestyle social process influences add further the complexity. Consequently, antidepressant treatment generally regarded open improvement, undoubtedly consequence inappropriately targeted pathophysiological This article reviews diverse array processes linked MDD, integrates these within perspective that emphasizes alterations in mitochondrial function, both centrally systemically. It proposed long-standing association MDD with suppressed serotonin availability reflective role precursor for melatonergic pathway. Astrocytes, astrocyte pathway, are highlighted crucial hubs integration wide biological underpinnings including gut dysbiosis permeability, stressors, which can act suppress capacity mitochondria upregulate consequences oxidant-induced changes patterned microRNAs subsequent gene responses. placed development context, how processes, such discrimination, physiologically regulate susceptibility MDD. Future research directions implications derived from this.

Язык: Английский

Psychological resilience to lifetime trauma and risk for cardiometabolic disease and mortality in older adults: A longitudinal cohort study

Journal of Psychosomatic Research, Год журнала: 2023, Номер 175, С. 111539 - 111539

Опубликована: Окт. 27, 2023

Язык: Английский