Genetic damage and potential mechanism exploration under different air pollution patterns by multi-omics
Environment International,
Год журнала:
2022,
Номер
170, С. 107636 - 107636
Опубликована: Ноя. 19, 2022
Ambient
air
pollution
was
classified
as
carcinogenic
to
humans
(Group
1)
for
lung
cancer.
DNA
damage
an
important
first
step
in
the
process
of
carcinogenesis,
and
could
also
be
induced
by
pollution.
In
this
study,
intratracheal
instillation
real-time
exposure
system
were
combined
establish
SHP
(short-term
high-level
PM2.5)
LLPO
(long-term
low-level
PM2.5
O3)
patterns,
respectively.
Hierarchical
levels
genetic
biomarkers
analyzed
explore
effects
rats.
Representative
repair
genes
from
different
pathways
selected
relative
expression
levels.
The
methylation
level
differentially
expressed
determined.
Besides,
miRNA
sequencing
non-targeted
metabolomic
analysis
performed
rat
lungs.
KEGG
multi-omics
used
potential
mechanism
under
patterns.
We
found
that
DSBs
chromosome
damage.
induce
oxidative
damage,
pattern
repaired
natural
repair.
Repair
involved
two
different.
higher
RAD51,
which
might
a
epigenetic
down-regulated
RAD51
DSBs.
29
overlapped
alterations
metabolic
identified
sequencing,
including
purine
metabolism
pyrimidine
after
exposure.
Differential
miRNAs
tissue
associated
with
apoptosis,
concluded
activated
targets
network
both
caused
short-term
can
alleviated
provided
possible
mechanisms
explain
increased
risk
Язык: Английский
Review of ecologically relevant in vitro bioassays to supplement current in vivo tests for whole effluent toxicity testing - Part 2: Non-apical endpoints
The Science of The Total Environment,
Год журнала:
2022,
Номер
851, С. 158094 - 158094
Опубликована: Авг. 17, 2022
Язык: Английский
Micronuclei in Fish Erythrocytes as Genotoxic Biomarkers of Water Pollution: An Overview
Reviews of Environmental Contamination and Toxicology,
Год журнала:
2021,
Номер
unknown, С. 195 - 240
Опубликована: Янв. 1, 2021
Язык: Английский
Assessment of Difference Between Heavy Metals Concentrations in Water and Zooplankton
Egyptian Journal of Aquatic Biology and Fisheries,
Год журнала:
2024,
Номер
28(1), С. 1335 - 1350
Опубликована: Янв. 1, 2024
Heavy
metals
are
among
the
most
dangerous
pollutants
in
natural
environment
due
to
their
persistent
toxicity
and
bioaccumulation
problems,
hence
they
considered
a
global
problem.
Additionally,
stubborn,
of
them
poisonous
aquatic
organisms
when
reach
particular
concentration.
Zooplankton
can
continue
serving
as
monitor
for
water
situation,
depending
on
how
highly
responsive
various
contaminants.
Zooplankton's
ability
accumulate
was
assessed
based
categories
factor
(BAF).
There
no
probability
since
all
heavy
metal
BAFs
were
less
than
1000
(BAF˂
1000),
however
iron
(Fe)
zooplankton
samples
from
two
drains
aluminum
(Al)
drain
one
sample
fell
into
1000<
BAF<
5000:
bio-accumulative
category.
The
pollution
index
(MPI)
calculated
compare
levels
overall
zooplankton.
In
studied
drains,
values
16.902
17.924.
therefore
be
widely
used
biological
monitoring
assessment
safe
environmental
metals.
Язык: Английский