mSphere, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

ABSTRACT Candida auris is a significant public health threat due to its environmental persistence and multidrug resistance, with echinocandins being the preferred treatment. However, in addition echinocandin tolerance heteroresistance may contribute treatment challenges. Echinocandin involves reduced drug-mediated killing, while ability of small cell subset grow at high drug concentrations. These phenomena facilitate emergence full resistance complicate clinical outcomes. The significance these mechanisms remains unclear, limited data correlating them failures. Research needed understand their impact, develop streamlined robust methods detect settings, explore mitigation strategies. pathogen’s range adaptations demands innovative approaches like spatial transcriptomics dissect complex responses improve patient

Язык: Английский