Nutrients,
Год журнала:
2022,
Номер
14(22), С. 4918 - 4918
Опубликована: Ноя. 20, 2022
Zinc
is
an
essential
trace
element,
and
anemia
the
most
common
blood
disorder.
The
association
of
zinc
with
may
be
divided
into
three
major
forms:
(1)
deficiency
contributing
to
anemia,
(2)
excess
intake
leading
(3)
abnormal
blood–zinc
levels
in
body.
In
cases,
coexists
iron
deficiency,
especially
pregnant
women
preschool-age
children.
To
a
lesser
extent,
cooperate
other
factors
lead
anemia.
It
seems
that
alone
does
not
result
it
need
Excess
rare.
However,
interferes
uptake
copper
results
leads
Animal
model
studies
indicate
redistributed
from
plasma
bones
bone
marrow
produce
new
red
cells.
Inadequate
status
(zinc
or
excess)
could
have
effects
on
anemia;
at
same
time,
render
handling
needs
observed
carefully,
supplementation
preventive
curative
effects.
Molecules,
Год журнала:
2022,
Номер
27(20), С. 7084 - 7084
Опубликована: Окт. 20, 2022
Aging
is
a
very
complex
process
that
accompanied
by
degenerative
impairment
in
many
of
the
major
functions
human
body
over
time.
This
inevitable
influenced
hereditary
factors,
lifestyle,
and
environmental
influences
such
as
xenobiotic
pollution,
infectious
agents,
UV
radiation,
diet-borne
toxins,
so
on.
Many
external
internal
signs
symptoms
are
related
with
aging
senescence,
including
skin
dryness
wrinkles,
atherosclerosis,
diabetes,
neurodegenerative
disorders,
cancer,
etc.
Oxidative
stress,
consequence
imbalance
between
pro-
antioxidants,
one
main
provoking
factors
causing
aging-related
damages
concerns,
due
to
generation
highly
reactive
byproducts
oxygen
nitrogen
species
during
metabolism,
which
result
cellular
damage
apoptosis.
Antioxidants
can
prevent
these
processes
extend
healthy
longevity
ability
inhibit
formation
free
radicals
or
interrupt
their
propagation,
thereby
lowering
level
oxidative
stress.
review
focuses
on
supporting
antioxidant
system
organism
balancing
diet
through
consumption
necessary
amount
natural
ingredients,
vitamins,
minerals,
polyunsaturated
fatty
acids
(PUFA),
essential
amino
acids,
probiotics,
plants’
fibers,
nutritional
supplements,
polyphenols,
some
phytoextracts,
drinking
water.
Biological Trace Element Research,
Год журнала:
2023,
Номер
201(12), С. 5640 - 5651
Опубликована: Март 31, 2023
Zinc
is
a
micronutrient
of
key
importance
for
human
health.
An
increasing
number
studies
indicate
that
zinc
plays
significant
role
in
bone
tissue's
normal
development
and
maintaining
homeostasis.
not
only
component
tissue
but
also
involved
the
synthesis
collagen
matrix,
mineralization,
turnover.
It
has
been
demonstrated
can
stimulate
runt-related
transcription
factor
2
(Runx2)
promote
differentiation
osteoblasts.
On
other
hand,
found
to
inhibit
osteoclast-like
cell
formation
decrease
resorption
by
stimulating
osteoclasts'
apoptosis.
Moreover,
regulates
RANKL/RANK/OPG
pathway,
thereby
facilitating
remodeling.
To
date,
all
mechanisms
Zn
activity
on
are
well
understood
documented.
The
review
aimed
present
current
state
research
tissue,
its
beneficial
properties,
effects
regeneration.
Since
calcium
phosphates
as
substitute
materials
increasingly
enriched
ions,
paper
included
an
overview
potential
such
filling
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Март 9, 2022
Zinc
(Zn)
deficiency
in
humans
is
an
emerging
global
health
issue
affecting
approximately
two
billion
people
across
the
globe.
The
situation
prevails
due
to
intake
of
Zn
deficient
grains
and
vegetables
worldwide.
Clinical
identification
remains
problematic
because
symptoms
do
not
appear
until
impair
vital
organs,
such
as
gastrointestinal
track,
central
nervous
system,
immune
skeletal,
system.
Lower
body
levels
are
also
responsible
for
multiple
physiological
disorders,
apoptosis,
organs
destruction,
DNA
injuries,
oxidative
damage
cellular
components
through
reactive
oxygen
species
(ROS).
causes
chronic
inflammation
lead
toward
several
diseases,
heart
cancers,
alcohol-related
malady,
muscular
contraction,
neuro-pathogenesis.
present
review
focused
on
growth-related
changes
under
conditions,
mechanisms
adopted
by
human
proper
functioning
systems,
importance
nutritional
nutraceutical
approaches
overcome
concluded
that
biofortified
food
best
source
compared
chemical
supplementation
avoid
their
negative
impacts
human.
Osteoarthritis
(OA)
is
a
degenerative
disease
that
often
causes
cartilage
lesions
and
even
osteochondral
damage.
Osteochondral
defects
induced
by
OA
are
accompanied
an
inflammatory
arthrosis
microenvironment
with
overproduced
reactive
oxygen
species
(ROS),
resulting
in
the
exacerbation
of
difficulty
regenerating
tissues.
Therefore,
it
urgently
needed
to
develop
scaffolds
can
not
only
promote
integrated
regeneration
subchondral
bone,
but
also
possess
ROS-scavenging
ability
protect
tissues
from
oxidative
stress.
Herein,
zinc-cobalt
bimetallic
organic
framework
(Zn/Co-MOF)
functionalized
bioceramic
designed
for
repairing
under
environment.
By
functionalizing
Zn/Co-MOF
on
3D-printed
beta-tricalcium
phosphate
(β-TCP)
scaffolds,
β-TCP
(MOF-TCP)
broad-spectrum
successfully
developed.
Benefiting
its
catalytic
active
sites
degradation
products,
endows
excellent
antioxidative
anti-inflammatory
properties
cells
ROS
invasion,
as
well
dual-bioactivities
simultaneously
inducing
osteogenic
chondrogenic
differentiation
vitro.
Furthermore,
vivo
results
confirm
MOF-TCP
accelerate
bone
severe
defects.
This
study
offers
promising
strategy
treating
other
diseases.
RSC Advances,
Год журнала:
2024,
Номер
14(5), С. 3359 - 3378
Опубликована: Янв. 1, 2024
Electrostatic
spinning
as
a
technique
for
producing
nanoscale
fibers
has
recently
attracted
increasing
attention
due
to
its
simplicity,
versatility,
and
loadability.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 23, 2024
The
damage
to
the
central
nervous
system
and
dysfunction
of
body
caused
by
spinal
cord
injury
(SCI)
are
extremely
severe.
pathological
process
SCI
is
accompanied
inflammation
nerve
cells.
Current
evidence
suggests
that
oxidative
stress,
resulting
from
an
increase
in
production
reactive
oxygen
species
(ROS)
imbalance
its
clearance,
plays
a
significant
role
secondary
during
SCI.
transcription
factor
nuclear
erythroid
2-related
2
(Nrf2)
crucial
regulatory
molecule
for
cellular
redox.
This
review
summarizes
recent
advancements
regulation
ROS-Nrf2
signaling
focuses
on
interaction
between
ROS
different
modes
neuronal
cell
death
after
SCI,
such
as
apoptosis,
autophagy,
pyroptosis,
ferroptosis.
Furthermore,
we
highlight
pathways
through
which
materials
science,
including
exosomes,
hydrogels,
nanomaterials,
can
alleviate
modulating
clearance.
provides
valuable
insights
directions
reducing
alleviating
stress.
Disruptions
in
metal
balance
can
trigger
a
synergistic
interplay
of
cuproptosis
and
ferroptosis,
offering
promising
solutions
to
enduring
challenges
oncology.
Here,
we
have
engineered
Cellular
Trojan
Horse,
named
MetaCell,
which
uses
live
neutrophils
stably
internalize
thermosensitive
liposomal
bimetallic
Fe-Cu
MOFs
(Lip@Fe-Cu-MOFs).
MetaCell
instigate
thereby
enhancing
treatment
efficacy.
Mirroring
the
characteristics
neutrophils,
evade
immune
system
not
only
infiltrate
tumors
but
also
respond
inflammation
by
releasing
therapeutic
components,
surmounting
traditional
barriers.
Notably,
Lip@Fe-Cu-MOFs
demonstrate
notable
photothermal
effects,
inciting
targeted
release
Fe-Cu-MOFs
within
cancer
cells
amplifying
action
ferroptosis.
has
demonstrated
outcomes
tumor-bearing
mice,
effectively
eliminating
solid
forestalling
recurrence,
leading
extended
survival.
This
research
provides
great
insights
into
complex
between
copper
iron
homeostasis
malignancies,
potentially
paving
way
for
innovative
approaches
treatment.
