IUBMB Life,
Год журнала:
2024,
Номер
76(11), С. 883 - 921
Опубликована: Авг. 1, 2024
Cancer
drug
resistance
poses
a
significant
obstacle
to
successful
chemotherapy,
primarily
driven
by
the
activity
of
ATP-binding
cassette
(ABC)
transporters,
which
actively
efflux
chemotherapeutic
agents
from
cancer
cells,
reducing
their
intracellular
concentrations
and
therapeutic
efficacy.
Recent
studies
have
highlighted
pivotal
role
long
noncoding
RNAs
(lncRNAs)
in
regulating
this
resistance,
positioning
them
as
crucial
modulators
ABC
transporter
function.
lncRNAs,
once
considered
transcriptional
noise,
are
now
recognized
for
complex
regulatory
capabilities
at
various
cellular
levels,
including
chromatin
modification,
transcription,
post-transcriptional
processing.
This
review
synthesizes
current
research
demonstrating
how
lncRNAs
influence
modulating
expression
transporters.
can
act
molecular
sponges,
sequestering
microRNAs
that
would
otherwise
downregulate
genes.
Additionally,
they
alter
epigenetic
landscape
these
genes,
affecting
activity.
Mechanistic
insights
reveal
contribute
thereby
altering
drugs
promoting
resistance.
Understanding
interactions
provides
new
perspective
on
basis
chemoresistance,
emphasizing
network
knowledge
not
only
deepens
our
understanding
biological
mechanisms
underlying
but
also
suggests
novel
strategies.
In
conclusion,
intricate
interplay
between
transporters
is
developing
innovative
solutions
combat
underscoring
importance
continued
field.
Journal of Hematology & Oncology,
Год журнала:
2022,
Номер
15(1)
Опубликована: Сен. 8, 2022
Abstract
Epithelial–mesenchymal
transition
(EMT)
is
an
essential
process
in
normal
embryonic
development
and
tissue
regeneration.
However,
aberrant
reactivation
of
EMT
associated
with
malignant
properties
tumor
cells
during
cancer
progression
metastasis,
including
promoted
migration
invasiveness,
increased
stemness,
enhanced
resistance
to
chemotherapy
immunotherapy.
tightly
regulated
by
a
complex
network
which
orchestrated
several
intrinsic
extrinsic
factors,
multiple
transcription
post-translational
control,
epigenetic
modifications,
noncoding
RNA-mediated
regulation.
In
this
review,
we
described
the
molecular
mechanisms,
signaling
pathways,
stages
tumorigenesis
involved
discussed
dynamic
non-binary
its
role
metastasis.
Finally,
summarized
challenges
immunotherapy
proposed
strategies
for
therapy
targeting
EMT.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(17), С. 9451 - 9451
Опубликована: Авг. 31, 2021
With
nearly
10
million
deaths,
cancer
is
the
leading
cause
of
mortality
worldwide.
Along
with
major
key
parameters
that
control
treatment
management,
such
as
diagnosis,
resistance
to
classical
and
new
chemotherapeutic
reagents
continues
be
a
significant
problem.
Intrinsic
or
acquired
chemoresistance
leads
recurrence
in
many
cases
eventually
causes
failure
successful
death
patients.
Various
determinants,
including
tumor
heterogeneity
microenvironment,
could
through
diverse
range
mechanisms.
In
this
review,
we
summarize
determinants
underlying
mechanisms
by
which
appears.
We
then
describe
strategies
have
been
implemented
studied
combat
lethal
phenomenon
management
treatment,
emphasis
on
need
improve
early
diagnosis
complemented
combination
therapy.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Фев. 17, 2023
Abstract
Drug
resistance
is
mainly
responsible
for
cancer
recurrence
and
poor
prognosis.
Epigenetic
regulation
a
heritable
change
in
gene
expressions
independent
of
nucleotide
sequence
changes.
As
the
common
epigenetic
mechanisms,
DNA
methylation,
histone
modification,
non-coding
RNA
have
been
well
studied.
Increasing
evidence
has
shown
that
aberrant
regulations
contribute
to
tumor
resistance.
Therefore,
targeting
regulators
represents
an
effective
strategy
reverse
drug
In
this
review,
we
summarize
roles
addition,
as
essential
factors
modifications,
demethylases
mediate
or
genomic
modifications.
Herein,
comprehensively
describe
functions
demethylase
family
including
lysine-specific
family,
Jumonji
C-domain-containing
arginine
fully
discuss
their
regulatory
mechanisms
related
therapeutic
strategies,
small-molecule
inhibitors
small
interfering
overcome
resistance,
are
also
described.
Science Translational Medicine,
Год журнала:
2022,
Номер
14(656)
Опубликована: Авг. 3, 2022
Triple-negative
breast
cancer
(TNBC)
is
an
aggressive
subtype
associated
with
early
metastatic
recurrence
and
worse
patient
outcomes.
TNBC
tumors
express
molecular
markers
of
the
epithelial-mesenchymal
transition
(EMT),
but
its
requirement
during
spontaneous
metastasis
in
vivo
remains
incompletely
understood.
We
demonstrated
that
from
a
genetically
engineered
mouse
model
(GEMM),
multiple
patient-derived
xenografts,
archival
samples
exhibited
large
populations
hybrid
E/M
cells
lead
invasion
ex
while
expressing
both
epithelial
mesenchymal
characteristics.
The
marker
vimentin
promoted
repressed
outgrowth.
next
tested
for
five
EMT
transcription
factors
observed
distinct
patterns
utilization
colony
formation.
These
differences
suggested
sequential
activation
programs
cascade.
Consistent
this
model,
our
longitudinal
single-cell
RNA
analysis
detected
three
different
EMT-related
patterns.
progressing
to
strongly
pattern
investigated
relative
versus
state
GEMM
metastases.
In
contexts,
we
heterogeneity
between
within
metastases
same
individual.
complex
spectrum
epithelial,
E/M,
cell
states
metastases,
suggesting
there
are
successful
strategies
distant
organ
colonization.
Together,
results
demonstrate
important
role
metastasis.
Cell Proliferation,
Год журнала:
2023,
Номер
56(6)
Опубликована: Фев. 19, 2023
Epithelial-mesenchymal
transition
(EMT)
or
mesenchymal-epithelial
(MET)
plays
critical
roles
in
cancer
metastasis.
Recent
studies,
especially
those
based
on
single-cell
sequencing,
have
revealed
that
EMT
is
not
a
binary
process,
but
heterogeneous
and
dynamic
disposition
with
intermediary
partial
states.
Multiple
double-negative
feedback
loops
involved
by
EMT-related
transcription
factors
(EMT-TFs)
been
identified.
These
between
drivers
MET
finely
regulate
the
state
of
cell.
In
this
review,
general
characteristics,
biomarkers
molecular
mechanisms
different
states
were
summarized.
We
additionally
discussed
direct
indirect
tumour
More
importantly,
article
provides
evidence
heterogeneity
closely
related
to
poor
prognosis
gastric
cancer.
Notably,
seesaw
model
was
proposed
explain
how
cells
themselves
remain
specific
states,
including
epithelial
state,
hybrid/intermediate
mesenchymal
state.
Additionally,
also
review
current
status,
limitations
future
perspectives
signalling
clinical
applications.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
160, С. 114398 - 114398
Опубликована: Фев. 9, 2023
The
importance
of
mitochondria
is
not
only
limited
to
energy
generation
but
also
in
several
physical
and
chemical
processes
critical
for
cell
survival.
Mitochondria
play
an
essential
role
cellular
apoptosis,
calcium
ion
transport
metabolism.
Mutation
the
nuclear
mitochondrial
genes,
altered
oncogenes/tumor
suppressor
deregulated
signalling
viability
are
major
reasons
cancer
progression
chemoresistance.
development
drug
resistance
patients
a
challenge
treatment
as
resistant
cells
often
more
aggressive.
numerous
types
exhibit
deregulation
function.
increased
biogenesis
its
dynamic
alteration
contribute
developing
resistance.
Further,
small
subpopulation
stem
heterogeneous
tumor
primarily
responsible
chemoresistance
has
attribute
dysfunction.
This
review
highlights
dysfunction
through
autophagy/mitophagy,
stemness.
Mitochondria-targeted
therapeutic
strategies
might
help
reduce
induced
by
various
drugs.
iScience,
Год журнала:
2024,
Номер
27(6), С. 109979 - 109979
Опубликована: Май 15, 2024
This
review
explores
the
hallmarks
of
cancer
resistance,
including
drug
efflux
mediated
by
ATP-binding
cassette
(ABC)
transporters,
metabolic
reprogramming
characterized
Warburg
effect,
and
dynamic
interplay
between
cells
mitochondria.
The
role
stem
(CSCs)
in
treatment
resistance
regulatory
influence
non-coding
RNAs,
such
as
long
RNAs
(lncRNAs),
microRNAs
(miRNAs),
circular
(circRNAs),
are
studied.
chapter
emphasizes
future
directions,
encompassing
advancements
immunotherapy,
strategies
to
counter
adaptive
integration
artificial
intelligence
for
predictive
modeling,
identification
biomarkers
personalized
treatment.
comprehensive
exploration
these
provides
a
foundation
innovative
therapeutic
approaches,
aiming
navigate
complex
landscape
enhance
patient
outcomes.
