Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7910 - 7910

Опубликована: Апрель 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Язык: Английский

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Inflammation: A New Look at an Old Problem

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 4596 - 4596

Опубликована: Апрель 21, 2022

Pro-inflammatory stress is inherent in any cells that are subject to damage or threat of damage. It defined by a number universal components, including oxidative stress, cellular response DNA damage, unfolded protein mitochondrial and endoplasmic reticulum changes autophagy, inflammasome formation, non-coding RNA response, formation an inducible network signaling pathways, epigenetic changes. The presence receptor secretory phenotype many the cause tissue pro-inflammatory stress. key phenomenon determining occurrence classical inflammatory focus microvascular (exudation, leukocyte migration alteration zone). This same reaction at systemic level leads development life-critical inflammation. From this standpoint, we can characterize common mechanisms pathologies differ their clinical appearance. division inflammation into alternative variants has deep evolutionary roots. Evolutionary aspects also described review. aim review provide theoretical arguments for need up-to-date theory relationship between human pathological processes based on integrative role molecular

Язык: Английский

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Mass Spectrometry Methods for Measuring Protein Stability

Chemical Reviews, Год журнала: 2022, Номер 122(8), С. 7690 - 7719

Опубликована: Март 22, 2022

Mass spectrometry is a central technology in the life sciences, providing our most comprehensive account of molecular inventory cell. In parallel with developments mass technologies targeting such assessments cellular composition, tools have emerged as versatile probes biomolecular stability. this review, we cover recent advancements branch that target proteins, centrally important class macromolecules accounts for biochemical functions and drug targets. Our efforts hydrogen-deuterium exchange, chemical cross-linking, ion mobility, collision induced unfolding, other techniques capable stability on proteomic scale. addition, focus range application areas where spectrometry-driven protein measurements made notable impacts, including studies membrane heat shock amyloidogenic biotherapeutics. We conclude by briefly discussing future vibrant fast-moving area research.

Язык: Английский

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Targeting HSF1 for cancer treatment: mechanisms and inhibitor development

Theranostics, Год журнала: 2023, Номер 13(7), С. 2281 - 2300

Опубликована: Янв. 1, 2023

Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive signaling. In addition to playing critical roles in cellular response, emerging evidence suggests that HSF1 also regulates non-heat transcriptional network handle metabolic, chemical, and genetic stress. The function transformation cancer development has been extensively studied recent years. Due important for coping with various stressful states, research on very active. New functions molecular mechanisms underlying these have continuously discovered, providing new targets novel treatment strategies. this article, we review the essential action cells, focusing more recently discovered their reflect advances biology. addition, emphasize regard inhibitors drug development.

Язык: Английский

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Fungi mediated detoxification of heavy metals: Insights on mechanisms, influencing factors and recent developments

Journal of Water Process Engineering, Год журнала: 2023, Номер 53, С. 103800 - 103800

Опубликована: Май 16, 2023

Язык: Английский

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Advances in the structures, mechanisms and targeting of molecular chaperones

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 12, 2025

Abstract Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention protein misfolding and abnormal aggregation, modulation homeostasis, protection cells from damage under constantly changing environmental conditions. As understanding biological mechanisms molecular chaperones has increased, their link with occurrence progression disease suggested that these proteins are promising targets for therapeutic intervention, drawing intensive interest. Here, we review recent advances determining structures heat shock 90 (HSP90) chaperone system complexes. We also describe features shed light on complicated mechanism operates through interactions various co-chaperones cycles. In addition, how affect diseases by regulating pathogenic been thoroughly analyzed. Furthermore, focus to systematically discuss clinical drug design strategies preclinical stage. Recent studies have identified variety novel targeting systems compounds act different those traditional inhibitors. Therefore, as more developed, will significantly contribute discovery new potential drugs.

Язык: Английский

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Stress granule‐associated TaMBF1c confers thermotolerance through regulating specific mRNA translation in wheat (Triticum aestivum)

New Phytologist, Год журнала: 2021, Номер 233(4), С. 1719 - 1731

Опубликована: Ноя. 17, 2021

Heat stress is a major limiting factor for global wheat production and causes dramatic yield loss worldwide. The TaMBF1c gene upregulated in response to heat wheat. Understanding the molecular mechanisms associated with responses will pave way improve thermotolerance. Through CRISPR/Cas9-based editing, polysome profiling coupled RNA-sequencing analysis, protein-protein interactions, we show that conferred via regulating specific translation results showed evolutionarily conserved diploid, tetraploid hexaploid species, its knockdown knockout lines increased sensitivity. colocalized granule complex interacts TaG3BP. affects efficiency of subset responsive genes, which are significantly enriched 'sequence-specific DNA binding' term. Moreover, expression network analysis demonstrated closely shock proteins. Our findings reveal contribution process, provide new target improving tolerance breeding programs.

Язык: Английский

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Can heat shock protein 70 (HSP70) serve as biomarkers in Antarctica for future ocean acidification, warming and salinity stress?

Polar Biology, Год журнала: 2022, Номер 45(3), С. 371 - 394

Опубликована: Янв. 24, 2022

Abstract The Antarctic Peninsula is one of the fastest-warming places on Earth. Elevated sea water temperatures cause glacier and ice melting. When icebergs melt into ocean, it “freshens” saltwater around them, reducing its salinity. oceans absorb excess anthropogenic carbon dioxide (CO 2 ) causing decline in ocean pH, a process known as acidification. Many marine organisms are specifically affected by warming, freshening Due to sensitivity Antarctica global using biomarkers best way for scientists predict more accurately future climate change provide useful information or ecological risk assessments. 70-kilodalton (kDa) heat shock protein (HSP70) chaperones have been used stress temperate tropical environments. induction HSP70 genes ( Hsp70 that alter intracellular proteins living signal triggered environmental temperature changes. Induction has observed both eukaryotes prokaryotes response stressors including increased decreased temperature, salinity, pH combined effects changes acidification salinity stress. Generally, HSP70s play critical roles numerous complex processes metabolism; their synthesis can usually be during stressful conditions. However, there question whether may serve excellent considering long residence time cold polar environment which appears greatly modified responding transcriptional systems. This review provides insight vital make them ideal candidates identifying resistance resilience abiotic associated with change, organisms.

Язык: Английский

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Pathway engineering facilitates efficient protein expression in Pichia pastoris

Applied Microbiology and Biotechnology, Год журнала: 2022, Номер 106(18), С. 5893 - 5912

Опубликована: Авг. 30, 2022

Язык: Английский

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A Dual Heat Shock Protein Down‐Regulation Strategy Using PDA/Cu/ICG/R Controlled by NIR “Switch” Enhances Mild‐Photothermal Therapy Effect

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(27)

Опубликована: Июнь 10, 2023

The purpose of this study is to down-regulate heat shock proteins and improve the mild photothermal therapy (mild-PTT) effect polydopamine (PDA) by preparing nanosystem Cu2+ indocyanine green (ICG)-loaded PDA nanospheres with surface modification integrin-targeted cyclic peptide (cRGD) (PDA/Cu/ICG/R), which can limit ATP synthesis through double mitochondrial destruction pathway. In vitro in vivo experiments using PDA/Cu/ICG/R irradiated an NIR laser demonstrate that when "OFF," undergo Fenton-like reaction tumor cells, producing a large amount hydroxyl radicals (·OH), leads oxidative stress cells. This cause phosphorylation dysfunction, resulting limited synthesis. When "ON," mild-PTT accelerate produce ·OH. Simultaneously, activate ICG reactive oxygen species (ROS) storm, amplify intracellular stress, continuously damage mitochondria. biodegradability greatly reduces risk toxicity caused long-term retention organisms. Finally, improvement successfully achieved pathway controlled "switch."

Язык: Английский

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