Fetal and obstetrics manifestations of mitochondrial diseases

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 23, 2024

Abstract During embryonic and neonatal development, mitochondria have essential effects on metabolic energetic regulation, shaping cell fate decisions leading to significant short- long-term offspring health. Therefore, perturbation mitochondrial function can a pathological effect pregnancy. Several shreds of evidence collected in preclinical models revealed that severe dysfunction is incompatible with life or leads critical developmental defects, highlighting the importance correct during embryo-fetal development. The mechanism impairing development unknown may include dysfunctional switch differentiating cells due decreased ATP production altered apoptotic signalling. Given central role fetal typical Mitochondrial Diseases (MDs) should, principle, be detectable However, little known about clinical manifestations MDs In this manuscript, we review suggesting affect highlight maternal outcomes provide wake-up call for targeted genetic diagnosis.

Язык: Английский

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Nanocarrier-Assisted Delivery of Berberine Promotes Diabetic Alveolar Bone Regeneration by Scavenging ROS and Improving Mitochondrial Dysfunction

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 10263 - 10282

Опубликована: Окт. 1, 2024

Oxidative stress and mitochondrial dysfunction are potential contributors to the compromised tissue regeneration capacity of alveolar bone in diabetic patients. Berberine, an active plant alkaloid, exhibits multiple pharmacological effects including antioxidation, blood glucose- lipid-lowering properties. However, it remains uncertain whether berberine can improve impaired osteogenesis type 2 diabetes mellitus (T2DM), its poor solubility oral bioavailability also constrain applications regeneration. Thus, our study aimed probe on marrow stem cells (BMSCs) a microenvironment, with greater emphasis developing suitable nano-delivery system for assessing capability repair defects.

Язык: Английский

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An Aptamer Sensor Based on Alendronic Acid-Modified Upconversion Nanoparticles Combined with Magnetic Separation for Rapid and Sensitive Detection of Thiamethoxam

Foods, Год журнала: 2025, Номер 14(2), С. 182 - 182

Опубликована: Янв. 9, 2025

The widespread use of thiamethoxam has led to pesticide residues that have sparked global concerns regarding ecological and human health risks. A pressing requirement exists for a detection method is both swift sensitive. Herein, we introduced an innovative fluorescence biosensor constructed from alendronic acid (ADA)-modified upconversion nanoparticles (UCNPs) linked with magnetic (MNPs) via aptamer recognition the thiamethoxam. Through base pairing, thiamethoxam-specific aptamer-functionalized MNPs (apt-MNPs) were integrated complementary DNA-functionalized UCNPs (cDNA-UCNPs) create MNPs@UCNPs biosensor. Thiamethoxam specifically attached apt-MNPs, leading their separation cDNA-UCNPs, which in turn reduction intensity at 544 nm following by external field. change (ΔI) was directly correlated concentration thiamethoxam, enabling quantitative analysis pesticide. With optimized parameters, capable quantifying within span 0.4-102.4 ng·mL-1, it achieved limit as minute 0.08 ng·mL-1. Moreover, leveraging properties MNPs, assay duration could be abbreviated 25 min. research exhibited precise sensing platform yielded promising results samples cucumber, cabbage, apple.

Язык: Английский

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Perspective on neonicotinoid insecticides in human exposure and risk assessment

Journal of Environmental Exposure Assessment, Год журнала: 2025, Номер 4(1)

Опубликована: Фев. 19, 2025

This perspective presents first-hand research insights into the pervasive environmental distribution of neonicotinoid insecticides (NEOs) and their consequent human exposure. Our findings reveal widespread NEO detection across biological matrices, indicating potential health risks highlighting critical gaps in current risk assessment paradigms. We identify an urgent need for longitudinal epidemiological studies, particularly focusing on vulnerable populations, to comprehensively assess NEO-related outcomes. These scientific should inform evidence-based policy reforms management strategies effectively protect both public integrity.

Язык: Английский

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Pesticide exposure and hippocampal neurogenesis: Role of ER stress and mitochondrial dysfunction

Advances in neurotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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