Chemical safety screening of products – better proactive
Journal of Chromatography A,
Год журнала:
2025,
Номер
1752, С. 465946 - 465946
Опубликована: Апрель 19, 2025
The
increasing
pressure
to
ensure
product
safety
in
a
global
market
comes
up
against
the
current
practice
of
targeting
only
known
hazardous
compounds
analysis.
However,
refers
not
but
also
unknown
or
hidden
hazards
that
are
very
important
know
and
avoid.
Shortcomings
limitations
currently
used
technologies
seem
cause
an
obvious
discrepancy
between
intended
actual
consumer
protection.
Products
as
safe
claimed
by
stakeholders.
An
existing
overlooked
proactive
screening
with
prioritization
strategy
is
brought
into
focus
it
offers
unique
solution.
It
can
handle
complexity
thousands
identity
toxicity
figure
out
compounds,
both
unknown.
Using
hardly
any
sample
preparation
effect
detection
at
early
position
workflow
game
changer
overlook
compounds.
All
analytical
needed,
key
re-arrangement
instrument
order,
i.e.
firstly
hazard-related
(effect
first)
secondly,
on
identification
prioritized
Such
revealed
previously
products
be
safe.
highly
sustainable,
affordable,
all-in-one
2LabsToGo-Eco
easy-to-use
planar
bioassays
empowers
stakeholders
implement
dynamic
risk
management.
transition
greater
efficacy
protection
needs
incentives
critical
review
aims
stimulate
debate.
Язык: Английский
Drug-induced thrombocytopenia severity and toxicity（ditpst）:binary classification of drugs by human thrombocytopenia toxicity
Expert Opinion on Drug Safety,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Background
Drug-induced
thrombocytopenia
(DITP)
often
occurs
in
patients
during
clinical
treatment.
However,
clinicians
usually
fail
to
distinguish
which
drugs
can
be
plausible
culprits
accurately.
We
aimed
develop
a
large
comprehensive
drug
benchmark
database
with
DITP
toxicity
using
the
recommended
method
by
FDA.
Язык: Английский
Molecular response of Chironomus riparius to antibiotics
Current Research in Toxicology,
Год журнала:
2025,
Номер
unknown, С. 100239 - 100239
Опубликована: Май 1, 2025
Язык: Английский
Development of a roadmap for action on the application of Omics and associated Bioinformatics Approaches in Risk Assessment
EFSA Supporting Publications,
Год журнала:
2024,
Номер
21(10)
Опубликована: Окт. 1, 2024
Abstract
The
implementation
of
omics
technologies
and
associated
bioinformatics
approaches
hold
significant
promise
for
generating
additional
evidence
food
feed
risk
assessments
thereby
enhancing
the
European
Food
Safety
Authority
(EFSA)
capacity
to
deliver
scientific
opinions
guidance
documents
in
future.
To
explore
this
possibility,
EFSA
launched
a
Call
development
roadmap
identify
main
actions
needed
wider
use
Omics
future
assessments.
address
objective,
action
outlines
six
project
proposals.
These
proposals
are
based
on
comprehensive
mapping
state‐of‐the‐art
research,
EFSA's
activities
as
well
current
planned
from
other
relevant
regulatory
bodies
organisations.
outlined
recommendations
also
some
identified
knowledge
gaps
highlight
added
value
that
further
investments
different
&
safety
domains
could
bring.
In
addition,
work
addresses
key
challenges
blockers
might
hinder
integration
assessment
leverages
opportunities
cooperation
with
external
stakeholders.
Finally,
provides
suggestions
how
may
more
broadly
effectively
engage
stakeholders
science.
Язык: Английский
Advancing chemical safety assessment through an omics-based characterization of the test system-chemical interaction
Frontiers in Toxicology,
Год журнала:
2023,
Номер
5
Опубликована: Ноя. 9, 2023
Assessing
chemical
safety
is
essential
to
evaluate
the
potential
risks
of
exposure
human
health
and
environment.
Traditional
methods
relying
on
animal
testing
are
being
replaced
by
3R
(reduction,
refinement,
replacement)
principle-based
alternatives,
mainly
depending
in
vitro
test
Adverse
Outcome
Pathway
framework.
However,
these
approaches
often
focus
properties
compound,
missing
broader
chemical-biological
interaction
perspective.
Currently,
lack
comprehensive
molecular
characterization
system
results
limited
real-world
representation
contextualization
toxicological
effect
under
study.
Leveraging
omics
data
strengthens
understanding
responses
different
biological
systems,
emphasizing
holistic
interactions
when
developing
methods.
Here,
we
discuss
relevance
meticulous
two
assessment
relevant
scenarios
how
omics-based,
data-driven
can
improve
future
generation
alternative
Язык: Английский
A Novel Support Vector Machine-Based One-Day, Single-Dose Prediction Model of Genotoxic Hepatocarcinogenicity in Rats
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 20, 2024
Abstract
The
development
of
a
rapid
and
accurate
model
for
determining
the
genotoxicity
carcinogenicity
chemicals
is
crucial
effective
cancer
risk
assessment,
it
also
contributes
to
prevention.
This
study
aims
develop
one-day,
single-dose
identifying
genotoxic
hepatocarcinogens
(GHCs)
in
rats.
Microarray
gene
expression
data
from
livers
rats
administered
single
dose
58
compounds,
including
5
GHCs,
was
obtained
Open
TG-GATEs
database
used
identification
marker
genes
construction
predictive
classifier
identify
GHCs
We
identified
10
markers
commonly
responsive
all
them
construct
support
vector
machine-based
classifier.
effectively
distinguishes
other
demonstrating
100%
sensitivity
over
96%
specificity.
To
further
assess
model’s
effectiveness
reliability,
we
conducted
multi-institutional
one-day
oral
administration
studies
on
These
examined
64
23
with
via
quantitative
PCR
(qPCR)
24
hours
after
administration.
Our
results
demonstrate
that
qPCR
analysis
an
alternative
microarray
analysis.
GHC
showed
high
accuracy
achieving
91%
(21/23)
specificity
93%
(38/41)
across
multiple
validation
three
institutions.
In
conclusion,
present
proves
be
reliable
highly
sensitive
tool
anticipated
valuable
screening
potential
GHCs.
Язык: Английский
A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats
Archives of Toxicology,
Год журнала:
2024,
Номер
98(8), С. 2711 - 2730
Опубликована: Май 18, 2024
Язык: Английский
New Approach Methodologies (NAMs) to Support Regulatory Decisions for Chemical Safety
Letizia Carramusa,
Wilfrieda Mune,
Neil Hunt
и другие.
FSA research and evidence.,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Язык: Английский
Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin
Archives of Toxicology,
Год журнала:
2023,
Номер
97(11), С. 2903 - 2917
Опубликована: Сен. 4, 2023
Abstract
Omics
techniques
have
been
increasingly
recognized
as
promising
tools
for
Next
Generation
Risk
Assessment.
Targeted
metabolomics
offer
the
advantage
of
providing
readily
interpretable
mechanistic
information
about
perturbed
biological
pathways.
In
this
study,
a
high-throughput
LC–MS/MS-based
broad
targeted
system
was
applied
to
study
nitrofurantoin
metabolic
dynamics
over
time
and
concentration
provide
mechanistic-anchored
approach
point
departure
(PoD)
derivation.
Upon
exposure
at
five
concentrations
(7.5
µM,
15
20
30
µM
120
µM)
four
points
(3,
6,
24
48
h),
intracellular
metabolome
HepG2
cells
evaluated.
total,
256
uniquely
identified
metabolites
were
measured,
annotated,
allocated
in
13
different
metabolite
classes.
Principal
component
analysis
(PCA)
univariate
statistical
showed
clear
metabolome-based
effects.
Mechanistic
evidenced
differential
activation
cellular
pathways
indicative
early
adaptive
hepatotoxic
response.
At
low
concentrations,
effects
seen
mainly
energy
lipid
metabolism,
mid
range,
antioxidant
response
by
increased
levels
glutathione
(GSH)
from
de
novo
GSH
synthesis
pathway.
highest
depletion
GSH,
together
with
alternations
reflective
mitochondrial
impairments,
Finally,
metabolomics-based
PoD
derived
multivariate
PCA
using
whole
set
measured
metabolites.
This
allows
entire
dataset
derive
that
can
be
mechanistically
anchored
established
key
events.
Our
results
show
suitability
high
throughput
investigate
mechanisms
hepatoxicity
departures
linked
existing
adverse
outcome
contribute
development
new
ones.
Язык: Английский
Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children
Journal of Xenobiotics,
Год журнала:
2024,
Номер
14(1), С. 350 - 367
Опубликована: Март 5, 2024
Background:
We
sought
to
replicate
our
2015
findings
linking
chemical
intolerance
in
parents
with
the
risk
of
their
children
developing
autism
and/or
ADHD.
Drawing
upon
2021
discovery
a
strong
association
between
and
mast
cells,
we
propose
an
explanation
for
this
link.
Methods:
In
population-based
survey
U.S.
adults,
used
internationally
validated
Quick
Environmental
Exposure
Sensitivity
Inventory
(QEESI)
assess
symptom
severity
intolerance.
Parents
were
asked
how
many
biological
had
been
diagnosed
Results:
scores
top
versus
bottom
tenth
percentile
5.7
times
reporting
child
2.1
Conclusions:
High
among
autism,
coupled
cell
activation
as
plausible
biomechanism
intolerance,
suggest
that
(1)
QEESI
can
identify
individuals
at
increased
risk,
(2)
environmental
counseling
may
reduce
personal
exposures
(3)
global
rise
ADHD
be
due
fossil-fuel-derived
biogenic
toxicants
epigenetically
“turning
on”
or
off”
critical
genes
transmitted
transgenerationally.
It
is
important
note
study
was
observational
nature;
such,
further
research
needed
using
controlled
trials
confirm
causality
explore
proposed
mechanism.
Язык: Английский